My research examines how the applied physical, psychical, and phenomenological plague-time prophylactic boundaries condition urban space within early modern London. As theatre offers a locus for sharing the human experience, creative interactions with plague-time prevention may offer crucial insights into how plague spatial orders were understood, assimilated, and experienced. These latent experiences will be engaged with through examining how applied defensive boundaries, such as quarantine, reorientate the spatial paradigms within the early modern playhouse space itself, and the conceptual worlds within its drama. My aim is to explore these dramatic articulations of plague-time space and their interactions with the material performance space, as alert and critical models of contemporary prophylactic practice, and as cultural records of a largely unknown early modern experience.