Carl R Krynicki BSc (Hons); MSc; AKC; MBPsS

School of Psychology
Research Associate

Contact details

Address
Institute for Mental Health
School of Psychology
University of Birmingham,
National Centre for Mental Health,
25 Vincent Drive,
Birmingham, B15 2FG

Qualifications

  • PhD Psychiatry University of Birmingham (ongoing)
  • Associate of King’s College, London (2012)
  • MSc Clinical Neuroscience (2011) Institute of Psychiatry, King’s College, London
  • BSc (Hons) Psychology (2010) University of Leicester

Teaching

  • Intercalated BMedSc in Psychological Medicine
  • MBChB - Year 1, Doctors, Patients and Society (DPS) Module
  • MBChB - Year 2, Decision Making (DEM) Module

Research

Current research interests focus on the relationship between the depressive and negative symptom domains in schizophrenia; and immune dysfunction in schizophrenia.

ECLIPSE: Building Resilience and Recovery through Enhancing Cognition and Quality of Life in the early Psychosis. ECLIPSE is a large multi-centre study consisting of 6 sites. The C.I. is Professor Dame Til Wykes and Professor Eileen Joyce and the University of Birmingham P.I. is Dr Rachel Upthegrove. This programme grant aims to develop a training programme to deliver cognitive remediation. Part of this programme grant is a placebo-controlled RCT assessing cognitive remediation as a therapy to improve cognition and functional recovery in FEP patients, which will also be evaluated by method of delivery. 

PRONIA: Personalised Prognostic Tools for Early Psychosis Management. This study is a large EU funded study consisting of 8 universities and co-ordinated by the University of Munich. The C.I. is Professor Nikolaos Koutsouleris and the University of Birmingham P.I’s are Professor Stephen Wood and Dr Rachel Upthegrove. This study aims to utilise imaging and clinical data to optimise candidate biomarkers to the prediction and staging of psychosis and generate a prognostic system that generalises across different mental health services. 

BioPoP: Biological correlates of dimensional symptoms of psychosis. This study aims to discover whether neuroimaging and cellular biomarkers can be identified for specific symptom dimensions in first episode psychosis. This has important implications for the accurate early identification of patients with poor prognosis and the development of novel, targeted, treatments.

BeneMin Study: BeneMin is a double blind, randomised controlled trial which aims to evaluate the effectiveness and understand the mechanism of minocycline taken in addition to standard care in preventing the development or worsening of negative symptoms in schizophrenia. BeneMin is a multicentre trial consisting of 7 sites with the host site being the University of Manchester, headed by Professor Bill Deakin. This study builds on the demonstrated proof of concept of the efficacy of minocycline 

Publications

Deakin, B., Suckling, J., Barnes, T. R. E., Byrne, K., Chaudhry, I. B., Dazzan, P., Drake, R. J., Giordano, A., Husain, N., Jones, P. B., Joyce, E., Knox, E., Krynicki, C., Lawrie, S. M., Lewis, S., Lisiecka-Ford, D. M., Nikkheslat, N., Pariante, C. M., Smallman, R., Watson, A., Williams, S. C. R., Upthegrove, R. & Dunn, G. 2018. The Benefit Of minocycline on negative symptoms of schizophrenia in patients with recent-onset psychosis (BeneMin): a randomised, double-blind, placebo-controlled trial. The Lancet Psychiatry, 5, 885-894.

Krynicki, C., Upthegrove, R., Suckling, J., Dazzan, P., Joyce, E., Lawrie, S., Husain, N., Chaudhry, I., Dunn, G., Jones, P., Lisiecka, D., Lewis, S., Barnes, T., Williams, S., Hopkins, S., Drake, R., Smallman, R., Giordano, A., Pariante, C. & Deakin, B. 2018a. T46. Targeting the immune system to treat depression and negative symptoms in schizophrenia. Schizophrenia Bulletin, 44, S131-S131.

Upthegrove, R., Krynicki, C., Gordianno, A., Pariante, C., Rowland, T., Barnes, N., Marwaha, S., Perry, B., Dazzan, P. & Deakin, J. 2018. 30.1 immune pathogenesis of psychosis: the challenge of co-morbidity. Schizophrenia Bulletin, 44, S48-S48.

Krynicki CR, Upthegrove R, Deakin JFW, Barnes TRE (2018) The relationship between negative symptoms and depression in schizophrenia – A systematic review. Acta Psychiatrica Scandinavica (In press).

Patel M, Chawla R, Krynicki CR, Rankin P and Upthegrove R (2014) Health beliefs and carer burden in first episode psychosis. BMC Psychiatry 14:171

Al-Sharifi A, Krynicki CR and Upthegrove R  (2015) Self-harm and ethnicity: A systematic review. Int J Soc Psychiatry, 61, 600-12.

View all publications in research portal