School of Psychology
Interim Head of School
- School of Psychology
University of Birmingham
I am a behavioural neuroscientist primarily interested in the mechanisms and functions of memory processes. In particular, I currently study the phenomenon of memory reconsolidation, which may have applications in the understanding of and treatment of conditions such as post-traumatic stress disorder and drug addiction.
Joff Lee's research is focused on the basic mechanisms of learning and memory. These range from the neural circuits that support memory acquisition and persistence, to the cellular mechanisms that operate within those circuits. In particular, he is interested in the different phases that occur in the lifetime of a memory: acquisition, stabilisation and retrieval/expression. His recent work has paid particular attention to the phenomenon of memory reconsolidation, whereby a memory may be modified after its retrieval, perhaps to maintain its adaptive relevance.
The study of memory reconsolidation is a major focus of Dr Lee's research, especially in relation to conditions such as post-traumatic stress disorder and drug addiction which depend largely upon the formation of extremely powerful and persistent emotional memories. It may be possible, therefore, to reduce the impact of these memories by blocking their reconsolidation. By using preclinical models of emotional learning and memory, Dr Lee's work explores the clinical benefits of such an approach.
Posttraumatic stress disorder
Flavell, C & Lee, J 2019, 'Dopaminergic D1 receptor signalling is necessary, but not sufficient for cued fear memory destabilisation', Psychopharmacology. https://doi.org/10.1007/s00213-019-05338-5
Lee, JLC, Amorim, FE, Cassini, LF & Amaral, OB 2019, 'Different temporal windows for CB1 receptor involvement in contextual fear memory destabilisation in the amygdala and hippocampus', PLoS ONE, vol. 14, no. 1, e0205781. https://doi.org/10.1371/journal.pone.0205781
Tay, KR, Flavell, C, de Freitas Cassini, L, Wimber, M & Lee, J 2018, 'Post-retrieval re-learning strengthens hippocampal memories via destabilization and reconsolidation', The Journal of Neuroscience. https://doi.org/10.1523/JNEUROSCI.2618-18.2018
de Freitas Cassini, L, Flavell, C, Amaral, O & Lee, J 2017, 'On the transition from reconsolidation to extinction of contextual fear memories', Learning & memory, vol. 24, pp. 392-399. https://doi.org/10.1101/lm.045724.117
Lee, J, Bertoglio, L, Guimaraes, F & Stevenson, CW 2017, 'Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders', British Journal of Pharmacology. https://doi.org/10.1111/bph.13724
Song, C, Stevenson, CW, Guimaraes, F & Lee, J 2016, 'Bidirectional effects of cannabidiol on contextual fear memory extinction', Frontiers in Pharmacology, vol. 7, 493. https://doi.org/10.3389/fphar.2016.00493
Jurkus, R, Day, H, Guimaraes, F, Lee, J, Bertoglio, L & Stevenson, CW 2016, 'Cannabidiol regulation of learned fear: implications for treating anxiety-related disorders', Frontiers in Pharmacology, vol. 7, pp. 454. https://doi.org/10.3389/fphar.2016.00454/full
Heath, FC, Jurkus, R, Bast, T, Pezze, MA, Lee, JLC, Voigt, JP & Stevenson, CW 2015, 'Dopamine D1-like receptor signalling in the hippocampus and amygdala modulates the acquisition of contextual fear conditioning', Psychopharmacology, vol. 232, no. 14, pp. 2619-2629. https://doi.org/10.1007/s00213-015-3897-y
Exton-McGuinness, M & Lee, J 2015, 'Reduction in responding for sucrose and cocaine reinforcement by disruption of memory reconsolidation', eNeuro, vol. 2, no. 2, pp. 1-17. https://doi.org/10.1523/ENEURO.0009-15.2015
Exton-McGuinness, MTJ, Lee, JLC & Reichelt, AC 2014, 'Updating memories-The role of prediction errors in memory reconsolidation', Behavioural Brain Research, vol. 278C, pp. 375-384. https://doi.org/10.1016/j.bbr.2014.10.011
Exton-McGuinness, MTJ, Patton, RC, Sacco, LB & Lee, JLC 2014, 'Reconsolidation of a well-learned instrumental memory', Learning & memory, vol. 21, no. 9, pp. 468-77. https://doi.org/10.1101/lm.035543.114
Lee, JLC & Flavell, CR 2014, 'Inhibition and enhancement of contextual fear memory destabilization', Frontiers in Behavioral Neuroscience, vol. 8, 144. https://doi.org/10.3389/fnbeh.2014.00144
Reichelt, AC & Lee, JLC 2013, 'Memory reconsolidation in aversive and appetitive settings', Frontiers in Behavioral Neuroscience, vol. 7, 118. https://doi.org/10.3389/fnbeh.2013.00118
Reichelt, AC, Exton-McGuinness, MT & Lee, JLC 2013, 'Ventral tegmental dopamine dysregulation prevents appetitive memory destabilization', The Journal of Neuroscience, vol. 33, no. 35, pp. 14205-10. https://doi.org/10.1523/JNEUROSCI.1614-13.2013
Lee, J, Nader, K & Schiller, D 2017, 'An update on memory reconsolidation updating', Trends in Cognitive Sciences. https://doi.org/10.1016/j.tics.2017.04.006
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