The 100,000 Genomes Project – evaluating the delivery mechanism

The Health Services Management Centre at the University of Birmingham is undertaking an evaluation of the implementation of the West Midlands Genomic Medicine Centre (WMGMC). The evaluation will consider the WMGMC’s ability to embed and translate genomic technologies into mainstream medicine, thus contributing to the emerging knowledge-base on how the NHS will need to adapt in order to be ready to use genomics as part of its routine care.

The Prime Minister announced the 100,000 Genomes project - the largest of its kind in the world - in December 2012, and gave a commitment to sequence 100,000 genomes from approx. 70,000 people with cancer or a rare disease by the end of 2017.  The contracts for the First Wave Genomic Medicine Centres, of which the West Midlands is one, were awarded in December 2014.  The contract specification requires a GMC Lead Organisation, fully responsible for delivery, with a number of GMC Local Delivery Partners (LDPs) who will consent and recruit patients, perform surgery and resect tissue, provide clinical data and process samples to extract DNA. In the West Midlands, University Hospitals Birmingham is the Lead organisation, working in close collaboration with Birmingham Children’s Hospital and Birmingham Women’s Hospital. The West Midlands GMC has more LDP sites than any other GMC.

The evaluation is taking place between January and December 2016. It will involve the synthesis of literature and evidence, in-depth interviews at a national, local and regional level, across the LDP sites, and focus groups with clinicians.


January 2016 - December 2016


Hilary Brown

Professor Mark Exworthy 


Interim report for June 2016

Full report for January 2017


Academic Health Science Network