Professor Holms main research interest is to gain knowledge on how factors like dietary protein digestion and amino acid absorption rates as well as whole body and skeletal muscle amino acid fluxes and protein turnover rates are 1) validly measured by stable isotopically labelled substances, and 2) affected by intake of different protein sources and energy intake. Further, the impact of muscular activity and physical activity on whole body and skeletal muscle amino acid fluxes and protein turnover rates is investigated in various conditions. The responses are sought translated into long-term adaptations in muscle protein mass.
The main goal for Professor Holms research is to create evidence and develop strategies for nutritional and/or muscular activity recommendations that can support maintenance and growth or limit loss of muscle mass in older age and during challenged conditions like hospitalization and physio rehabilitation.
The The Milke Levy Fund has granted Prof. Lars Holm to the study entitled Oral Nutritional Supplementation to be conducted in 2019-2020 at School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
The main purpose of this study is to investigate how a milk-protein based high energy nutritional supplementation at breakfast and pre-bedtime timepoints affects whole body muscle protein turnover rates in slightly hypocaloric older individuals.
The study is conducted by Ph.D. student Yusuke Nishimura who will carry out the experiments in 2019 and analyse samples in 2019 and 2020. The results from the study will be published in open-access, peer-reviewed scientific journals during 2020 and 2021 and the main outcomes will be accessible for every one being interested via the present web-page.
Enabling Technologies Mass Spectrometry
Metabolite Mass Spectrometry Facility, SportExR