Selected publications:
1: Fisch D, Clough B, Domart MC, Encheva V, Bando H, Snijders AP, Collinson LM, Yamamoto M, Shenoy AR, Frickel EM. Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death. Cell Rep. 2020 Aug 11;32(6):108008. doi: 10.1016/j.celrep.2020.108008. PMID: 32783936; PMCID: PMC7435695.
2: Yoshida N, Domart MC, Peddie CJ, Yakimovich A, Mazon-Moya MJ, Hawkins TA, Collinson L, Mercer J, Frickel EM, Mostowy S. The zebrafish as a novel model for the in vivo study of Toxoplasma gondii replication and interaction with macrophages. Dis Model Mech. 2020 Jul 20;13(7):dmm043091. doi: 10.1242/dmm.043091. PMID: 32461265; PMCID: PMC7390642.
3: Frickel EM. One gene to rule them all in a chronic brain infection. Nature. 2020 Mar;579(7797):34-35. doi: 10.1038/d41586-020-00564-w. PMID: 32123364.
4: Fisch D, Clough B, Frickel EM. Human immunity to Toxoplasma gondii. PLoS Pathog. 2019 Dec 12;15(12):e1008097. doi: 10.1371/journal.ppat.1008097. PMID: 31830133; PMCID: PMC6907746.
5: Fisch D, Yakimovich A, Clough B, Mercer J, Frickel EM. Image-Based Quantitation of Host Cell-Toxoplasma gondii Interplay Using HRMAn: A Host Response to Microbe Analysis Pipeline. Methods Mol Biol. 2020;2071:411-433. doi: 10.1007/978-1-4939-9857-9_21. PMID: 31758464.
6: Clough B, Finethy R, Khan RT, Fisch D, Jordan S, Patel H, Coers J, Frickel EM. C57BL/6 and 129 inbred mouse strains differ in Gbp2 and Gbp2b expression in response to inflammatory stimuli in vivo. Wellcome Open Res. 2019 Aug 20;4:124. doi: 10.12688/wellcomeopenres.15329.1. PMID: 31544161; PMCID: PMC6749937.
7: Fisch D, Bando H, Clough B, Hornung V, Yamamoto M, Shenoy AR, Frickel EM. Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis. EMBO J. 2019 Jul 1;38(13):e100926. doi: 10.15252/embj.2018100926. Epub 2019 Jun 3. PMID: 31268602; PMCID: PMC6600649.
8: Evans RJ, Sundaramurthy V, Frickel EM. The Interplay of Host Autophagy and Eukaryotic Pathogens. Front Cell Dev Biol. 2018 Sep 13;6:118. doi: 10.3389/fcell.2018.00118. PMID: 30271774; PMCID: PMC6146372.
9: Sanecka A, Yoshida N, Kolawole EM, Patel H, Evavold BD, Frickel EM. T Cell Receptor-Major Histocompatibility Complex Interaction Strength Defines Trafficking and CD103+ Memory Status of CD8 T Cells in the Brain. Front Immunol. 2018 Jun 5;9:1290. doi: 10.3389/fimmu.2018.01290. PMID: 29922298; PMCID: PMC5996069.
10: Napolitano A, van der Veen AG, Bunyan M, Borg A, Frith D, Howell S, Kjaer S, Beling A, Snijders AP, Knobeloch KP, Frickel EM. Cysteine-Reactive Free ISG15 Generates IL-1β-Producing CD8α<sup>+</sup> Dendritic Cells at the Site of Infection. J Immunol. 2018 Jul 15;201(2):604-614. doi: 10.4049/jimmunol.1701322. Epub 2018 Jun 11. PMID: 29891555; PMCID: PMC6036233.
11: Encheva V, Foltz C, Snijders AP, Frickel EM. Murine Gbp1 and Gbp2 are ubiquitinated independent of Toxoplasma gondii infection. BMC Res Notes. 2018 Mar 6;11(1):166. doi: 10.1186/s13104-018-3267-z. PMID: 29510761; PMCID: PMC5840767.
12: Yoshida N, Frickel EM, Mostowy S. Macrophage-Microbe Interactions: Lessons from the Zebrafish Model. Front Immunol. 2017 Dec 1;8:1703. doi: 10.3389/fimmu.2017.01703. PMID: 29250076; PMCID: PMC5717010.
13: Saeij JP, Frickel EM. Exposing Toxoplasma gondii hiding inside the vacuole: a role for GBPs, autophagy and host cell death. Curr Opin Microbiol. 2017 Dec;40:72-80. doi: 10.1016/j.mib.2017.10.021. Epub 2017 Nov 12. PMID: 29141239; PMCID: PMC7004510.
14: Foltz C, Napolitano A, Khan R, Clough B, Hirst EM, Frickel EM. TRIM21 is critical for survival of Toxoplasma gondii infection and localises to GBP-positive parasite vacuoles. Sci Rep. 2017 Jul 12;7(1):5209. doi: 10.1038/s41598-017-05487-7. PMID: 28701773; PMCID: PMC5507857.
15: Clough B, Frickel EM. The Toxoplasma Parasitophorous Vacuole: An Evolving Host-Parasite Frontier. Trends Parasitol. 2017 Jun;33(6):473-488. doi: 10.1016/j.pt.2017.02.007. Epub 2017 Mar 19. PMID: 28330745.
16: Clough B, Wright JD, Pereira PM, Hirst EM, Johnston AC, Henriques R, Frickel EM. K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human Cells. PLoS Pathog. 2016 Nov 22;12(11):e1006027. doi: 10.1371/journal.ppat.1006027. PMID: 27875583; PMCID: PMC5119857.
17: Sanecka A, Yoshida N, Dougan SK, Jackson J, Shastri N, Ploegh H, Blanchard N, Frickel EM. Transnuclear CD8 T cells specific for the immunodominant epitope Gra6 lower acute-phase Toxoplasma gondii burden. Immunology. 2016 Nov;149(3):270-279. doi: 10.1111/imm.12643. Epub 2016 Aug 17. PMID: 27377596; PMCID: PMC5046057.
18: Johnston AC, Piro A, Clough B, Siew M, Virreira Winter S, Coers J, Frickel EM. Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii. Cell Microbiol. 2016 Aug;18(8):1056-64. doi: 10.1111/cmi.12579. Epub 2016 Mar 10. PMID: 26874079; PMCID: PMC4961618.
19: Sanecka A, Frickel EM. Use and abuse of dendritic cells by Toxoplasma gondii. Virulence. 2012 Nov 15;3(7):678-89. doi: 10.4161/viru.22833. Epub 2012 Nov 15. PMID: 23221473; PMCID: PMC3545950.
20: Virreira Winter S, Niedelman W, Jensen KD, Rosowski EE, Julien L, Spooner E, Caradonna K, Burleigh BA, Saeij JP, Ploegh HL, Frickel EM. Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it. PLoS One. 2011;6(9):e24434. doi: 10.1371/journal.pone.0024434. Epub 2011 Sep 8. PMID: 21931713; PMCID: PMC3169597.
All publications:
https://pubmed-ncbi-nlm-nih-gov.ezproxyd.bham.ac.uk/?term=frickel+em&sort=date