Dr Patrick Moynihan PhD

Dr Patrick Moynihan

BBSRC David Phillips Fellow

Contact details

Address
School of Biosciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr. Moynihan is a BBSRC David Phillips Fellow in the School of Biosciences. His group employs multi-disciplinary approach to study the cell wall of mycobacteria. This includes biochemistry, genetics, analytical and synthetic chemistry and structural biology.

Qualifications

BSc. (Hons.) in Molecular Biology and Genetics, University of Guelph

MSc in Microbiology, University of Guelph

PhD in Molecular and Cellular Biology, University of Guelph

Publications

Recent publications

Article

Harding, C, Cadby, I, Moynihan, P & Lovering, A 2021, 'A rotary mechanism for allostery in bacterial hybrid malic enzymes', Nature Communications, vol. 12, no. 1, 1228. https://doi.org/10.1038/s41467-021-21528-2

Harding, CJ, Huwiler, SG, Somers, H, Lambert, C, Ray, LJ, Till, R, Taylor, G, Moynihan, PJ, Sockett, RE & Lovering, AL 2020, 'A lysozyme with altered substrate specificity facilitates prey cell exit by the periplasmic predator Bdellovibrio bacteriovorus', Nature Communications, vol. 11, no. 1, 4817 . https://doi.org/10.1038/s41467-020-18139-8

Burke, C, Jankute, M, Moynihan, P, Gonzalez Del Rio, R, Li, X, Esquivias, J, Lelièvre, J, Cox, JAG, Sacchettini, J & Besra, GS 2020, 'Development of a novel secondary phenotypic screen to identify hits within the mycobacterial protein synthesis pipeline', FASEB BioAdvances, vol. 2, no. 10, pp. 600-612. https://doi.org/10.1096/fba.2020-00022

Preciado-Llanes, L, Aulicino, A, Canals, R, Moynihan, PJ, Zhu, X, Jambo, N, Nyirenda, TS, Kadwala, I, Sousa Gerós, A, Owen, SV, Jambo, KC, Kumwenda, B, Veerapen, N, Besra, GS, Gordon, MA, Hinton, JCD, Napolitani, G, Salio, M & Simmons, A 2020, 'Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease', Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.2007472117

Cadby, IT, Basford, SM, Nottingham, R, Meek, R, Lowry, R, Lambert, C, Tridgett, M, Till, R, Ahmad, R, Fung, R, Hobley, L, Hughes, WS, Moynihan, PJ, Sockett, RE & Lovering, A 2019, 'Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase.', The EMBO journal, vol. 38, no. 15, e100772. https://doi.org/10.15252/embj.2018100772

Meek, RW, Cadby, IT, Moynihan, PJ & Lovering, AL 2019, 'Structural basis for activation of a diguanylate cyclase required for bacterial predation in Bdellovibrio', Nature Communications, vol. 10, no. 1, 4086 . https://doi.org/10.1038/s41467-019-12051-6

Moynihan, PJ, Cadby, IT, Veerapen, N, Jankute, M, Crosatti, M, Mukamolova, GV, Lovering, AL & Besra, GS 2019, 'The hydrolase LpqI primes mycobacterial peptidoglycan recycling', Nature Communications, vol. 10, no. 1, 2647. https://doi.org/10.1038/s41467-019-10586-2

Kharkwal, SS, Veerapen, N, Jervis, P, Bhowruth, V, Besra, AK, North, SJ, Haslam, SM, Dell, A, Hobrath, J, Quaid, P, Moynihan, P, Cox, LR, Kharkwal, H, Zauderer, M, Besra, GS & Porcelli, SA 2018, 'Photoactivable glycolipid antigens generate stable conjugates with CD1d for invariant Natural Killer T cell activation', Bioconjugate Chemistry. https://doi.org/10.1021/acs.bioconjchem.8b00484

Turapov, O, Forti, F, Kadhim, B, Ghisotti, D, Sassine, J, Straatman-Iwanowska, A, Bottrill, AR, Moynihan, PJ, Wallis, R, Barthe, P, Cohen-Gonsaud, M, Ajuh, P, Vollmer, W & Mukamolova, GV 2018, 'Two Faces of CwlM, an Essential PknB Substrate, in Mycobacterium tuberculosis', Cell Reports, vol. 25, no. 1, pp. 57-67.e5. https://doi.org/10.1016/j.celrep.2018.09.004

Moynihan, P & Besra, G 2017, 'Colworth prize lecture 2016: exploiting new biological targets from a whole-cell phenotypic screening campaign for TB drug discovery', Microbiology, vol. 163, no. 10. https://doi.org/10.1099/mic.0.000522

Sychantha, D, Jones, CS, Little, DJ, Moynihan, PJ, Robinson, H, Galley, NF, Roper, DI, Dowson, CG, Howell, PL & Clarke, AJ 2017, 'In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA)', PLoS pathogens, vol. 13, no. 10, pp. e1006667. https://doi.org/10.1371/journal.ppat.1006667

Abrahams, KA, Cox, JAG, Fütterer, K, Rullas, J, Ortega-Muro, F, Loman, NJ, Moynihan, PJ, Pérez-Herrán, E, Jiménez, E, Esquivias, J, Barros, D, Ballell, L, Alemparte, C & Besra, GS 2017, 'Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface', Scientific Reports, vol. 7, no. 1, 9430. https://doi.org/10.1038/s41598-017-09642-y

Abrahams, KA, Chung, C-W, Ghidelli-Disse, S, Rullas, J, Rebollo-López, MJ, Gurcha, SS, Cox, JAG, Mendoza, A, Jiménez-Navarro, E, Martínez-Martínez, MS, Neu, M, Shillings, A, Homes, P, Argyrou, A, Casanueva, R, Loman, NJ, Moynihan, PJ, Lelièvre, J, Selenski, C, Axtman, M, Kremer, L, Bantscheff, M, Angulo-Barturen, I, Izquierdo, MC, Cammack, NC, Drewes, G, Ballell, L, Barros, D, Besra, GS & Bates, RH 2016, 'Identification of KasA as the cellular target of an anti-tubercular scaffold', Nature Communications, vol. 7, 12581. https://doi.org/10.1038/ncomms12581, https://doi.org/10.1038/ncomms12581

Letter

Moynihan, PJ 2018, 'The lasting impact of the 2013 beveridge poster award', Canadian Journal of Microbiology, vol. 64, no. 9, pp. 645-645. https://doi.org/10.1139/cjm-2017-0458

Other contribution

Itabangi, H, Sephton-Clark, PCS, Zhou, X, Insua, I, Probert, M, Correia, J, Moynihan, P, Gebremariam, T, Gu, Y, Lin, L, Ibrahim, AS, Brown, GD, King, JS, Trillo, FF, Ballou, ER & Voelz, K 2019, A bacterial endosymbiont enables fungal immune evasion during fatal mucormycete infection.. https://doi.org/10.1101/584607

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