Recent publications
Article
Lovering, A, Harding, C, Cadby, I & Moynihan, P 2021, 'A rotary mechanism for allostery in bacterial hybrid malic enzymes', Nature Communications, vol. 12, no. 1228, 1228.
Harding, CJ, Huwiler, SG, Somers, H, Lambert, C, Ray, LJ, Till, R, Taylor, G, Moynihan, PJ, Sockett, RE & Lovering, AL 2020, 'A lysozyme with altered substrate specificity facilitates prey cell exit by the periplasmic predator Bdellovibrio bacteriovorus', Nature Communications, vol. 11, no. 1, 4817 . https://doi.org/10.1038/s41467-020-18139-8
Burke, C, Jankute, M, Moynihan, P, Gonzalez Del Rio, R, Li, X, Esquivias, J, Lelièvre, J, Cox, JAG, Sacchettini, J & Besra, GS 2020, 'Development of a novel secondary phenotypic screen to identify hits within the mycobacterial protein synthesis pipeline', FASEB BioAdvances, vol. 2, no. 10, pp. 600-612. https://doi.org/10.1096/fba.2020-00022
Preciado-Llanes, L, Aulicino, A, Canals, R, Moynihan, PJ, Zhu, X, Jambo, N, Nyirenda, TS, Kadwala, I, Sousa Gerós, A, Owen, SV, Jambo, KC, Kumwenda, B, Veerapen, N, Besra, GS, Gordon, MA, Hinton, JCD, Napolitani, G, Salio, M & Simmons, A 2020, 'Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease', Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.2007472117
Cadby, IT, Basford, SM, Nottingham, R, Meek, R, Lowry, R, Lambert, C, Tridgett, M, Till, R, Ahmad, R, Fung, R, Hobley, L, Hughes, WS, Moynihan, PJ, Sockett, RE & Lovering, A 2019, 'Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase.', The EMBO journal, vol. 38, no. 15, e100772. https://doi.org/10.15252/embj.2018100772
Meek, RW, Cadby, IT, Moynihan, PJ & Lovering, AL 2019, 'Structural basis for activation of a diguanylate cyclase required for bacterial predation in Bdellovibrio', Nature Communications, vol. 10, no. 1, 4086 . https://doi.org/10.1038/s41467-019-12051-6
Moynihan, PJ, Cadby, IT, Veerapen, N, Jankute, M, Crosatti, M, Mukamolova, GV, Lovering, AL & Besra, GS 2019, 'The hydrolase LpqI primes mycobacterial peptidoglycan recycling', Nature Communications, vol. 10, no. 1, 2647. https://doi.org/10.1038/s41467-019-10586-2
Kharkwal, SS, Veerapen, N, Jervis, P, Bhowruth, V, Besra, AK, North, SJ, Haslam, SM, Dell, A, Hobrath, J, Quaid, P, Moynihan, P, Cox, LR, Kharkwal, H, Zauderer, M, Besra, GS & Porcelli, SA 2018, 'Photoactivable glycolipid antigens generate stable conjugates with CD1d for invariant Natural Killer T cell activation', Bioconjugate Chemistry. https://doi.org/10.1021/acs.bioconjchem.8b00484
Turapov, O, Forti, F, Kadhim, B, Ghisotti, D, Sassine, J, Straatman-Iwanowska, A, Bottrill, AR, Moynihan, PJ, Wallis, R, Barthe, P, Cohen-Gonsaud, M, Ajuh, P, Vollmer, W & Mukamolova, GV 2018, 'Two Faces of CwlM, an Essential PknB Substrate, in Mycobacterium tuberculosis', Cell Reports, vol. 25, no. 1, pp. 57-67.e5. https://doi.org/10.1016/j.celrep.2018.09.004
Moynihan, P & Besra, G 2017, 'Colworth prize lecture 2016: exploiting new biological targets from a whole-cell phenotypic screening campaign for TB drug discovery', Microbiology, vol. 163, no. 10. https://doi.org/10.1099/mic.0.000522
Sychantha, D, Jones, CS, Little, DJ, Moynihan, PJ, Robinson, H, Galley, NF, Roper, DI, Dowson, CG, Howell, PL & Clarke, AJ 2017, 'In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA)', PLoS pathogens, vol. 13, no. 10, pp. e1006667. https://doi.org/10.1371/journal.ppat.1006667
Abrahams, KA, Cox, JAG, Fütterer, K, Rullas, J, Ortega-Muro, F, Loman, NJ, Moynihan, PJ, Pérez-Herrán, E, Jiménez, E, Esquivias, J, Barros, D, Ballell, L, Alemparte, C & Besra, GS 2017, 'Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface', Scientific Reports, vol. 7, no. 1, 9430. https://doi.org/10.1038/s41598-017-09642-y
Abrahams, KA, Chung, C-W, Ghidelli-Disse, S, Rullas, J, Rebollo-López, MJ, Gurcha, SS, Cox, JAG, Mendoza, A, Jiménez-Navarro, E, Martínez-Martínez, MS, Neu, M, Shillings, A, Homes, P, Argyrou, A, Casanueva, R, Loman, NJ, Moynihan, PJ, Lelièvre, J, Selenski, C, Axtman, M, Kremer, L, Bantscheff, M, Angulo-Barturen, I, Izquierdo, MC, Cammack, NC, Drewes, G, Ballell, L, Barros, D, Besra, GS & Bates, RH 2016, 'Identification of KasA as the cellular target of an anti-tubercular scaffold', Nature Communications, vol. 7, 12581. https://doi.org/10.1038/ncomms12581, https://doi.org/10.1038/ncomms12581
Letter
Moynihan, PJ 2018, 'The lasting impact of the 2013 beveridge poster award', Canadian Journal of Microbiology, vol. 64, no. 9, pp. 645-645. https://doi.org/10.1139/cjm-2017-0458
Other contribution
Itabangi, H, Sephton-Clark, PCS, Zhou, X, Insua, I, Probert, M, Correia, J, Moynihan, P, Gebremariam, T, Gu, Y, Lin, L, Ibrahim, AS, Brown, GD, King, JS, Trillo, FF, Ballou, ER & Voelz, K 2019, A bacterial endosymbiont enables fungal immune evasion during fatal mucormycete infection.. https://doi.org/10.1101/584607
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