Dr Garret Rochford PhD, MSc

Dr Garret Rochford

School of Biosciences
Rsearch Fellow

Contact details

Dr Garret Rochford is interested in the molecular basis of chemotherapeutic resistance and how metabolism contributes to tumor suppression and oncogenesis.

Qualifications

BSc (Biomedical Science)

MSc (Clinical Laboratory Science)

PhD (Molecular Biology)

Biography

Dr. Garret Rochford graduated from Technological University Dublin (TUD) (formerly Dublin Institute of Technology) with a BSc in Biomedical Science and an MSc in Clinical Laboratory Science. Dr. Rochford briefly worked on a project developing a rapid ELISA test for the early detection of Alzheimer’s Disease in Trinity College Dublin before returning to TUD to pursue a PhD with Prof. Orla Howe on the mechanistic evaluation of novel copper-based chemotherapeutics and therapeutic resistance mechanisms in cisplatin therapy. He subsequently took up a Research Fellow position in the Hodges group at Birmingham examining the role of cytoglobin in chemotherapeutic resistance to cisplatin and is investigating 3D cell culture as a model for toxicological assessment and evaluation of chemotherapeutic action.

Postgraduate supervision

For list of projects offered by the Hodges group go to https://www.findaphd.com/

Research

Garret is interested in the application of targeted transcriptomics and proteomics to determine the mechanistic mode of action of chemotherapeutics and investigate resistance mechanisms in head and neck cancer. Garret is also interested in expanding the use of 3D tumor spheroid models of complex heterogeneous cancers in order to better model the hypoxic and metabolic gradients present in in vivo cancer tissues. Additionally, Garret is interested in investigating the metabolic contribution to oncogenesis, cancer progression and its role in mediating chemotherapeutic resistance.

Publications

  1. Garret Rochford, Zara Molphy, Kevin Kavanagh, Malachy McCann, Michael Devereux, Andrew Kellett, Orla Howe. Cu(II) phenanthroline-phenazine complexes dysregulate mitochondrial function and stimulate apoptosis. Metallomics, 2020; 12, 65-78. doi: 10.1039/C9MT00187E
  2. Garret Rochford, Zara Molphy, Niall Browne, Carla Surlis, Michael Devereux, Malachy McCann, Andrew Kellett, Orla Howe and Kevin Kavanagh. In-vivo evaluation of Galleria mellonella larvae to novel copper(II) phenanthroline-phenazine complexes. Journal of Inorganic Biochemistry, 2018; 186: 135-146. doi: 10.1016/j.jinorgbio.2018.05.020
  3. Mircea Balasa, Anne-Marie Miller, Sarah O'Dwyer, Siobhan Hutchinson, Aleksandra Rutkowska, Mary Gardiner, Caoimhe Hannigan, Christopher McGuigan, Laura Williams, Garret Rochford, Deirdre Lohan, Joseph Keavenny, Tom Schnittger, Robert Briggs, Sean Kennelly, Brian Lawlor. Diagnostic Utility of Cerebrospinal Fluid Biomarkers in Irish Subjects with Cognitive Impairment. Alzheimer’s & Dementia. 2017; 13(7): P341. doi: 10.1016/j.jalz.2017.06.067
  4. Laura Thornton, Vidya Dixit, Letícia O. N. Assad, Thales P.  Ribeiro, Daniela D. Queiroz, Andrew Kellett, Alan Casey, John Colleran, Marcos D. Pereira,  Garret Rochford, Malachy McCann, Denis O’Shea, Rita Dempsey, Siobhán McClean, Agnieszka Foltyn-Arfa Kia, Maureen Walsh, Bernie Creaven, Orla Howe, and Michael Devereux. Water soluble and photo-stable silver(I) dicarboxylate complexes containing 1,10-phenanthroline ligands: antimicrobial and anticancer chemotherapeutic potential, DNA interactions and antioxidant activity. J. Inorg. Biochem. 2016; 159: 120-132. doi: 10.1016/j.jinorgbio.2016.02.024
  5. Andreea Prisecaru, Vickie McKee, Orla Howe, Garret Rochford, Malachy McCann, John Colleran, Milan Pour, Niall Barron, Nicholas Gathergood, and Andrew Kellett. Regulating Bioactivity of Cu2+ Bis-1,10-phenanthroline Artificial Metallonucleases with Sterically Functionalized Pendant Carboxylates. J. Med. Chem. 2013; 56(21): 8599-8615. doi: 10.1021/jm401465m.