Dr Gerard Sheehan BSc, PhD

Dr Gerard Sheehan

School of Biosciences
Research Fellow

Contact details

Qualifications

  • B.Sc Biomedical Sciences (2016)
  • Postgraduate Certificate Teaching and Learning (2019)
  • PhD Biology (2019)

Biography

Dr Gerard Sheehan is a Research Fellow in the Prof. Robin May lab at the Institute of Microbiology and Infection at the University of Birmingham since September 2019. His main area of work focuses on is extracellular vesicles (EVs) from Cryptococcus gattii and their role in cell-cell communication and virulence. EVs are small (50-1000nm), secreted membrane ‘packages’ enclosing protein, RNA and carbohydrates. Dr Sheehan is more broadly interested in the interaction of fungi with their host as well as neglected tropical diseases. Previously, he obtained his PhD examining host – pathogen interactions using the Galleria mellonella larvae infection model and a range of important human pathogens such as Candida albicans, Aspergillus fumigatus, Klebsiella pneumoniae and Staphylococcus aureus at Maynooth University (Ireland). Dr Sheehan also utilises a range of ‘-omic’ based platforms including quantitative mass spectrometry to study the host – pathogen interactome.

Postgraduate supervision

Contact in advance if interested in undergraduate or MSc or MSci research projects or undergraduate summer internship opportunity’s through applying for external funding.

Research

  1. Gerard Sheehan & Kevin Kavanagh (2018) Analysis of the early cellular and humoral responses of Galleria mellonella larvae to infection by Candida albicans, Virulence; 9:1, 163-172. doi: 10.1080/21505594.2017.1370174.
  2. Gerard Sheehan, Gudmundur Bergsson, Noel G McElvaney, Emer P Reeves, Kevin Kavanagh (2018). The human cathelicidin antimicrobial peptide LL-37 promotes the growth of the pulmonary pathogen Aspergillus fumigatus. Infect Immun; 86:e00097-18.
  3. Gerard Sheehan, Gráinne Clarke, Kevin Kavanagh (2018). Characterisation of the cellular and proteomic response of Galleria mellonella larvae to the development of invasive aspergillosis. BMC Microbiology; 18:1. doi.org/10.1186/s12866-018-1208-6.
  4. Gerard Sheehan, Marcus Nagl, Kevin Kavanagh (2018). Exposure to N-chlorotaurine induces oxidative stress responses in Aspergillus fumigatus. J. Med. Microbiol; 68(2):279-288. doi: 10.1099/jmm.0.000900.
  5. Gerard Sheehan & Kevin Kavanagh (2019). Proteomic Analysis of the Responses of Candida albicans during Infection of Galleria mellonella larvae. J. Fungi; 5, 7. doi: 10.3390/jof5010007.
  6. Gerard Sheehan, Amy Dix, Kevin Kavanagh (2019). Utilization of Galleria mellonella larvae to characterize the development of Staphylococcus aureus infection. Microbiology; 165(8):863-875. doi: 10.1099/mic.0.000813.
  7. Gerard Sheehan, Mickey Konings, Wilson Lim, Ahmed Fahal, Wendy W. J. van de Sande, Kevin Kavanagh (2020). Proteomic analysis of the processes leading to Madurella mycetomatis grain formation in Galleria mellonella larvae. PLOS Neglected Tropical Diseases; doi:pntd.0008190.
  8. Gerard Sheehan*, Laura Tully, Kevin Kavanagh* (2020). Candida albicans increases the pathogenicity of Staphylococcus aureus during polymicrobial infection of Galleria mellonella. Microbiology. doi: 10.1099/mic.0.000892
  9. Farooq Ahmad Wani, Amaduddin, Babita Aneja, Gerard Sheehan, Kevin Kavanagh, Rabia Ahmad, Mohammad Abid and Rajan Patel (2019). Synthesis of Novel Benzimidazolium Gemini Surfactants and Evaluation of Their Anti-Candida Activity. ACS Omega 2019 4 (7), 11871-11879. doi.org/10.1021/acsomega.9b01056
  10. Ahmad Ajdidi, Gerard Sheehan, Khaled Abu Elteen and Kevin Kavanagh (2019). Assessment of in vitro and in vivo antifungal activity of atorvastatin. J. Med. Microbiol. Aug 28: 68(10):1497-1506. doi: 10.1099/jmm.0.001065.
  11. Dejana Kosanovic, Gerard Sheehan, Helen Grogan, Kevin Kavanagh (2019). Characterisation of the interaction of Pseudomonas putida and Pseudomonas tolaasii with Trichoderma aggressivum - competitors of Agaricus bisporus. Eur j plant pathol. 156. 111–121. DOI: 10.1007/s10658-019-01867-z.
  12. Ahmad Ajdidi, Gerard Sheehan and Kevin Kavanagh (2020). Exposure of Aspergillus fumigatus to Atorvastatin Leads to Altered Membrane Permeability and Induction of an Oxidative Stress Response. J. fungi 6(2), 42; https://doi.org/10.3390/jof6020042
  13.  Luigi Principe, Graziella Vecchio, Gerard Sheehan, Kevin Kavanagh, Gianluca Morroni, Valentina Viaggi, Alessandra di Masi, Daniele Roberto Giacobbe, Francesco Luzzaro, Roberto Luzzati, Stefano Di Bella (2020). Zinc chelators as carbapenem adjuvants for metallo-β-lactamase (MBL)-producing bacteria: in vitro and in vivo evaluation. Microb Drug Resist
  14. Gerard Sheehan, Gemma Farrell, Kevin Kavanagh (2020). Immune priming: the secret weapon of the insect world. Virulence 11 (1) 238-246.
  15. Gerard Sheehan, Amy Garvey, Michael Croke & Kevin Kavanagh (2018) Innate humoral immune defences in mammals and insects: The same, with differences ? Virulence, 9:1, 1625-1639, DOI: 10.1080/21505594.2018.1526531.
  16. Kevin Kavanagh & Gerard Sheehan (2018). The Use of Galleria mellonella Larvae to Identify Novel Antimicrobial Agents against Fungal Species of Medical Interest J. Fungi 2018, 4(3), 113.