Dr Sophie G Kellaway PhD, FHEA

Dr Sophie G Kellaway

Institute of Cancer and Genomic Sciences
Research Fellow

Contact details

Email
s.g.kellaway@bham.ac.uk
View my research portal
Address
IBR West
Institute of Cancer and Genomic Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT

Dr Kellaway is a Research Fellow in the Institute of Cancer and Genomic Sciences working on genomic and transcriptional dysregulation in acute myeloid leukaemia.

Qualifications

  • Fellow of the Higher Education Academy
  • PhD in Stem Cell Research, University of Manchester, 2016
  • BSc (Hons) in Genetics with Industrial Experience, University of Manchester, 2012
  • Member of the Royal Society of Biology

Biography

Dr Kellaway received her PhD from the University of Manchester in 2016, investigating stem cells from patients with Congenital Hyperinsulinism as a model system. Following this Sophie moved to University of Birmingham to work in the lab of Professor Constanze Bonifer, firstly utilising mouse embryonic stem cells to study the molecular roles of four different RUNX1-associated Acute Myeloid Leukaemia driver mutations including RUNX1-ETO, and subsequently dissecting the pathways which make RUNX1-ETO expressing stem cells grow.

Teaching

Research

Research interests

Dr Kellaway has a long-standing interest in utilising stem cells to understand disease – from her time as a Research Assistant at Epistem Ltd working with colorectal organoids, through her PhD using mesenchymal stem cells and induced pluripotent stem cells from patients with congenital hyperinsulinism. Sophie moved to Professor Bonifer’s group in 2016 where she used mouse embryonic stem cells to understand how different RUNX1-derived driver mutations contribute to Acute Myeloid Leukaemia (AML), through a combination of genomic assays and next-generation sequencing.

Current projects

Sophie’s current research integrates her interest in stem cells and the wider lab’s long history of expertise on t(8;21) AML to probe how leukemic stem cells in t(8;21) AML are regulated and grow. This work will be expanded to other AML drivers, particularly other RUNX1 mutations based on her previously published analyses.

Different mutant RUNX1 Oncoproteins Program

Google Scholar

Publications

A genome-wide relay of signalling-responsive enhancers drives hematopoietic specification. Benjamin Edginton-White*, Alexander Maytum*, Sophie G Kellaway, Debbie K Goode, Peter Keane, Inti Pagnuco, Salam A Assi, Luke Ames, Mary Clarke, Peter N Cockerill, Bertie Göttgens, Jean-Baptiste Cazier, Constanze Bonifer (2023) Nature Communications, 14: 267

Identification and interrogation of the gene regulatory network of CEBPA-double mutant Acute Myeloid Leukemia. Assunta Adamo*, Paulynn Chin*, Peter Keane, Salam A. Assi, Sandeep Potluri, Sophie G. Kellaway, Daniel Coleman, Anetta Ptasinska, H. Ruud Delwel, Peter N. Cockerill and Constanze Bonifer (2022) Leukemia (ePub ahead of print) 

Epigenetic regulator genes direct lineage switching in MLL/AF4 leukaemia. Ricky Tirtakusuma, Katarzyna Szoltysek, Paul Milne, Vasily Grinev, Anetta Ptasinska, Paulynn Chin, Claus Meyer, Sirintra Nakjang, Jayne Hehir-Kwa, Daniel Williamson, Pierre Cauchy, Peter Keane, Salam Assi, Minoo Ashtiani, Sophie Kellaway, Maria Imperato, Fotini Vogiatzi,Elizabeth Schweighart-James, Shan Lin, Mark Wunderlich, Janine Stutterheim, Alexander Komkov, Elena Zerkalenkova, Paul Evans, Hesta Mcneill, Alex Elder, Natalia Martinez-Soria, Sarah Fordham, Yuzhe Shi, Lisa Russell, Deepali Pal, Alexandra Smith, Zoya Kingsbury, Jennifer Becq, Cornelia Eckert, Oskar Haas, Peter Carey, Simon Bailey, Roderick Skinner, Natalia Miakova, Matthew Collin, Venetia Bigley, Muzlifah Haniffa, Rolf Marschalek, Christine Harrison, Catherine Cargo, Denis Schewe, Yulia Olshanskaya, Michael Thirman, Peter Cockerill, James Mulloy, Helen Blair, H. Vormoor, James Allan, Constanze Bonifer, Olaf Heidenreich, and Simon Bomken (2022) Blood, 140 (17): 1875-1890

Molecular basis of haematological disease caused by inherited or acquired RUNX1 mutations (Review).                           Sophie G Kellaway, Daniel J L Coleman, Peter N Cockerill, Manoj Raghavan, Constanze Bonifer (2022) Experimental Haematology, 111:1-12 

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal. Tina M Schnoeder, Adrian Schwarzer, Ashok Kumar Jayavelu, Chen-Jen Hsu, Joanna Kirkpatrick, Konstanze Döhner, Florian Perner, Theresa Eifert, Nicolas Huber, Patricia Arreba-Tutusaus, Anna Dolnik, Salam A Assi, Monica Nafria, Lu Jiang, Yu-Ting Dai, Zhu Chen, Sai-Juan Chen, Sophie G Kellaway, Anetta Ptasinska, Elizabeth S Ng, Edouard G Stanley, Andrew G Elefanty, Marcus Buschbeck, Holger Bierhoff, Steffen Brodt, Georg Matziolis, Klaus-Dieter Fischer, Andreas Hochhaus, Chun-Wei Chen, Olaf Heidenreich, Matthias Mann, Steven W Lane, Lars Bullinger, Alessandro Ori, Björn von Eyss, Constanze Bonifer, Florian Heidel (2022) Blood, 17;139(7):1080-1097 

Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories.                             Sophie G Kellaway*, Peter Keane*, Benjamin Edginton-White, Kakkad Regha, Ella Kennett, Constanze Bonifer (2021) Life Science Alliance, 4(2): e202000864 

RUNX1-EVI1 disrupts lineage determination and the cell cycle by interfering with RUNX1 and EVI1 driven gene regulatory networks. Sophie G Kellaway, Peter Keane, Ella Kennett, Constanze Bonifer (2021) Haematologica 106(6):1569-1580

t(8;21) Acute Myeloid Leukemia as a Paradigm for the Understanding of Leukemogenesis at the Level of Gene Regulation and Chromatin Programming (Review)  Sophie Kellaway*, Paulynn S Chin*, Farnaz Barneh*, Constanze Bonifer, Olaf Heidenreich (2020) Cells 9(12): 2681 

Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism.  Sophie G Kellaway, Karolina Mosinska, Zainaba Mohamed, Alexander Ryan, Stephen Richardson, Melanie Newbould, Indraneel Banerjee, Mark J Dunne and Karen E Cosgrove (2019) PLOS ONE 14(9): e0222350

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