Mr Neeraj Lal MBBS BSc PhD MRCS

Mr Neeraj Lal

Institute of Cancer and Genomic Sciences
NIHR Academic Clinical Lecturer in General Surgery

Contact details

2nd Floor, IBR West
Institute of Cancer and Genomic Sciences
University of Birmingham
B15 2TT

Mr Neeraj Lal is an Academic Clinical Lecturer in General Surgery.  His major research interest is in the immunogenomics of colorectal cancer, with the aim of developing new immunotherapeutic strategies in this common cancer type.  He has held current and previous research funding from the National Institute of Health and Care Research, Cancer Research UK, the Medical Research Council and the Royal College of Surgeons (England).

TEDx talk on Cancer Immunotherapy



  • PhD Cancer Sciences
  • MRCS (England)
  • MBBS
  • BSc Neuroscience


Neeraj completed core surgical training and then undertook his Cancer Research UK-funded PhD at the University of Birmingham in  Professor Willcox’s laboratory, with further supervision by Professor Gary Middleton and Professor Chris Tselepis.  This work investigated the immunogenomics of colorectal cancer, and led to multiple high impact publications that enhanced understanding of intra-tumoural immune responses. 

After completing his PhD, has was appointed as an NIHR Academic Clinical Lecturer in Professor Andrew Beggs’ group and the Academic Department of Surgery to further develop his work in the field of immunogenomics with the aim of successfully applying immunotherapeutics in colorectal cancer. 

He is currently focused on the development of and application of cancer organoid and immune cell co-culture models to identify and investigate novel targets for cancer immunotherapies. 

He is co-investigator on the ORB-AZ and Target ID studies, as well as the ROSSINI II  Randomised Clinical Trial.


Postgraduate supervision

Neeraj is supervising multiple clinical and non-clinical PhD students. He is interested in supervising doctoral research students in the following areas:

  • Solid tumour genetics/biology
  • Molecular pathology
  • Cancer immunology and immunotherapy


Research interests

Cancer immunology; cancer genetics and genomics; bioinformatics; organoid models

Other activities

Specialty Registrar in General and Colorectal Surgery


Recent publications


The LFD AI Consortium 2022, 'Machine learning for determining lateral flow device results for testing of SARS-CoV-2 infection in asymptomatic populations', Cell Reports Medicine, vol. 3, no. 10, 100784.

Wanigasooriya, K, Sarma, D, Woods, P, O’connor, P, Matthews, A, Aslam, M, Dando, C, Ferguson, H, Francombe, J, Lal, N, Murphy, P, Papettas, T, Ramcharan, S & Busby, K 2022, 'The benefits of index telephone consultations in patients referred on the two-week wait colorectal cancer pathway', Annals of the Royal College of Surgeons of England.

Cragg, J, Mushtaq, F, Lal, N, Garnham, A, Hallissey, M, Graham, T & Shiralkar, U 2021, 'Surgical cognitive simulation improves real-world surgical performance: randomized study', BJS Open, vol. 5, no. 3, zrab003.

RIFT Study Group on behalf of the West Midlands Research Collaborative & Morton, D 2020, 'Appendicitis risk prediction models in children presenting with right iliac fossa pain (RIFT study): a prospective, multicentre validation study', The Lancet Child & Adolescent Health.

RIFT Study Group on behalf of the West Midlands Research Collaborative 2020, 'Evaluation of appendicitis risk prediction models in adults with suspected appendicitis: Identifying adults at low risk of appendicitis', British Journal of Surgery.

Brooks, J, Antao Mobre De Menezes, ARE, Ibrahim, M, Archer, L, Lal, N, Bagnall, C, Zeidler, SVV, Valentine, H, Spruce, R, Batis, N, Bryant, J, Hartley, M, Kaul, B, Ryan, G, Bao, R, Khattri, A, Lee, S, Ogbureke, KUE, Middleton, G, Tennant, D, Beggs, A, Deeks, J, West, CML, Cazier, J-B, Willcox, B, Seiwert, TY & Mehanna, H 2019, 'Development and validation of a combined hypoxia and immune prognostic classifier for head and neck cancer', Clinical Cancer Research, vol. 25, no. 17, pp. 5315-5328.,

Horniblow, RD, Bedford, M, Hollingworth, R, Evans, S, Sutton, E, Lal, N, Beggs, A, Iqbal, TH & Tselepis, C 2017, 'B-RAF mutations are associated with increased iron regulatory protein-2 expression in colorectal tumourigenesis', Cancer Science.

Lal, N, Willcox, C, Beggs, A, Taniere, P, Middleton, G, Tselepis, C & Willcox, B 2017, 'Endothelial protein C receptor is overexpressed in colorectal cancer as a result of amplification and hypomethylation of chromosome 20q', Journal of Pathology: Clinical Research, vol. 3, no. 3, pp. 155–170.

Lal, N, White, BS, Goussous, G, Pickles, OJ, Mason, M, Beggs, AD, Taniere, P, Willcox, BE, Guinney, J & Middleton, G 2017, 'KRAS mutation and Consensus Molecular Subtypes 2 and 3 are independently associated with reduced immune infiltration and reactivity in colorectal cancer', Clinical Cancer Research.

Pachnio, A, Ciaurriz, M, Begum, J, Lal, N, Zuo, J, Beggs, A & Moss, P 2016, 'Cytomegalovirus infection leads to development of high frequencies of cytotoxic virus-specific CD4+ T Cells targeted to vascular endothelium', PLoS pathogens, vol. 12, no. 9, e1005832.

Lal, N, Beggs, AD, Willcox, BE & Middleton, GW 2015, 'An immunogenomic stratification of colorectal cancer : implications for development of targeted immunotherapy', OncoImmunology, vol. 4, no. 3, e976052.

Bhangu, A, Nepogodiev, D, Lal, N & Bowley, DM 2012, 'Meta-analysis of predictive factors and outcomes for failure of non-operative management of blunt splenic trauma', Injury, vol. 43, no. 9, pp. 1337-1346.

Lal, N, Singh, P, Sellahewa, C & Patel, R 2012, 'Mortality following Hartmann's procedure – correlation of Dr. Foster's report with CR-POSSUM', International journal of surgery (London, England), vol. 10, no. 9, pp. 480-483.

Huang, WL, King, VR, Curran, OE, Dyall, SC, Ward, RE, Lal, N, Priestley, JV & Michael-Titus, AT 2007, 'A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury', Brain, vol. 130, no. 11, pp. 3004-3019.


Mehanna, HM, Brooks, J, Menezes, A, Ibrahim, M, Lal, N, Archer, L, Zeidler, SV, Bao, R, Khattri, A, Valentine, H, Spruce, R, Batis, N, Bryant, J, Beggs, AD, Tennant, D, West, C, Middleton, GW, Cazier, J-B, Willcox, B & Seiwert, TY 2018, 'Development and validation of a combined metabolic and immune prognostic classifier for head and neck cancer', Journal of Clinical Oncology, vol. 36, no. 15 Suppl, pp. 6049-6049.

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