Dr Lara Worthington PhD, MSc

Dr Lara Worthington

Institute of Cancer and Genomic Sciences
Post-Doctoral Researcher

Contact details

Institute of Cancer and Genomic Sciences
College of Medical and Dental Sciences
University of Birmingham
B15 2TT

Lara Worthington is currently a post-doctoral researcher based at Birmingham Children’s hospital (BCH) within the Children's Brain Tumour Research Team. Her interest is in the potential use of imaging biomarkers as predictors of visual function in children with Optic Pathway Glioma (OPG).

She recently completed her PhD thesis entitled ‘Investigation of Compressed sensing into the acceleration of Magnetic Resonance Spectroscopic Imaging’.


  • PhD in the use of Compressed Sensing for acceleration of Magnetic Resonance Spectroscopic Imaging, University of Birmingham, 2015
  • MSc in Physical Sciences of Imaging in the Biomedical Sciences (PSIBS) (with distinction)-University of Birmingham, 2011
  • MSc in Medical Engineering and Physics (with distinction)-University of London, 1995


After completing a degree in Physics at the University of Surrey, Lara Worthington trained as a medical physicist at Kings College Hospital, London in 1995. From there she worked for 18 months as a radiotherapy engineer at the Royal London Hospital. Having an interest in computer programming she decided to become a software developer with a private company in 1998, gaining skills in software testing and C++ programming. Wishing to return to medical physics she took a post in Nuclear Medicine and Diagnostic Radiology at Wolverhampton’s New Cross Hospital where it became apparent her skills were in research. She therefore decided to pursue a full-time PhD with the University of Birmingham’s (PSIBS) department. Wishing to combine her skills in medical imaging and software development she completed her thesis based at the Birmingham Children’s Hospital (BCH) in the investigation of image reconstruction with Compressed Sensing as a means to accelerate Magnetic Resonance Spectroscopic Imaging (MRSI). After submission she is now still based at BCH as a post-doctoral researcher investigating the use of functional Magnetic Resonance Imaging (MRI) techniques as biomarkers of visual deficit in children with Optic pathway Glioma (OPG).


The current area of research based at Birmingham Children’s Hospital (BCH) is the investigation into the potential of Magnetic Resonance Spectroscopic Imaging (MRSI) and Diffusion Tensor Imaging (DTI) as predictive biomarkers of visual function deficit in children with low grade gliomas in the optic pathway, Optic Pathway Glioma (OPG). 

Previous research activity also at BCH involved the development of software to reconstruct retrospective MRSI datasets using compressed sensing, and to investigate its effect on the spatial integrity of the resultant metabolic images.


Worthington L A, Wilson M, Arvanitis T N, Peet A C, Davies N P, The effect of Compressed sensing reconstruction on the Spatial resolution of Magnetic Resonance Spectroscopic Imaging. In:Proceeding of the 21st Annual Meeting, Salt Lake City, USA, 2013. p.2009 

Worthington L A, Wilson M, Arvanitis T N, Peet A C, Davies N P, Investigation of Spatial Resolution in clinical Magnetic Resonance Spectroscopic Imaging reconstructed with Compressed Sensing. In:Proceeding of the BC-ISMRM, 18th Annual Scientific Meeting Churchill College, Cambridge, 2012

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