Dr Jason Yap BSc (Hons), MBBS, MRCOG, PhD

Dr Jason Yap

Institute of Cancer and Genomic Sciences
NIHR funded Academic Clinical Lecturer

Contact details

Address
Institute of Cancer and Genomic Sciences
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT

Jason is an NIHR-funded Academic Clinical Lecturer in Gynaecological Oncology working at the Institute of Cancer and Genomic Sciences.

He leads a laboratory-based research group and has developed a stream of translational research relating to the pathogenesis and treatment of vulval neoplasia. He is also a joint principal investigator for a phase II clinical trial investigating the effectiveness of EGCG, a green tea polyphenol, in the treatment of vulvar intraepithelial neoplasia (VIN), a premalignant lesion of the vulva.

Jason has received funding from Cancer Research UK, The Pathology Society, The National Institute of Health Research, and The Royal College of Obstetricians and Gynaecologists.

Qualifications

  • PhD in Cancer Studies, University of Birmingham, 2016
  • Member of the Royal College of Obstetricians and Gynaecologists (MRCOG), 2010
  • Bachelor of Medicine, Bachelor of Surgery (MBBS), University College London, 2005
  • Intercalated BSc degree in Pharmacology, University College London, 2002

Biography

Jason studied medicine at University College London, UK, graduating in 2005 with an award in the subject of Obstetrics and Gynaecology. He completed his Foundation Doctor training in the North London Deanery and was then appointed into the Specialist Training Programme in Obstetrics and Gynaecology in 2007 by the West Midlands Deanery.

In 2012, he was awarded the Clinical Research Training Fellowship by Cancer Research UK and undertook a three year laboratory-based PhD study with Prof Ciaran Woodman, Prof David Luesley and Dr Christopher Dawson at the University of Birmingham.

Upon completing his PhD, he was appointed as an NIHR-funded Academic Clinical Lecturer in 2016. His translational research focuses on improving treatment outcomes for women with pre-malignant and malignant disease of the vulva, a disease arises through high-risk HPV-dependent and independent routes.

In 2016, he was awarded the Edgar-Gentilli Research Prize and the Florence and William Blaire Bell Research Fellowship by the Royal College of Obstetricians and Gynaecologists, UK, for his research into the pathobiology of vulval cancer. Jason is also a joint Principal Investigator for an NIHR-funded phase II clinical trial, EPIVIN, which evaluates the effectiveness of a novel topical therapy for women with vulvar intraepithelial neoplasia (uVIN).

He is passionate about understanding the pathobiology of vulval neoplasia and utilises his knowledge in basic sciences to develop better treatment for his patients.

Teaching

  • MB ChB 2nd year tutor for Cancer: Causes to Cures module - cancer epidemiology
  • MB ChB 2nd year tutor for Cancer: Causes to Cures module - from mutation to treatment
  • MB ChB clinical tutor for Obstetrics and Gynaecology and Clinical Oncology modules
  • Mentor for PhD student in Institute of Cancer and Genomic Sciences

Postgraduate supervision

  • MRes students in laboratory based projects
  • PhD student in laboratory and clinical based projects

Research

Jason’s research focuses mainly on improving the outcome of women with vulval neoplasia, translating fundamental laboratory discoveries into clinical practice and vice versa. Together with his mentor, Prof Sean Kehoe, he also works on primary ovarian cancer.

His research is divided into two main disciplines as follow:

Basic Science (Translational Research)

  • The pathobiology of high-risk HPV- induced neoplasia
  • Field cancerization in squamous cell carcinoma of the vulva
  • Epigallocathecin-3-gallate (EGCG), a potential therapy for  vulvar intraepithelial neoplasia
  • Sonic Hedgehog signalling in vulval squamous cell cancer and high-grade serous ovarian cancer
  • Biomarker discovery

Clinical

  • Phase II randomised control trial evaluating the use of topical Epigallocathecin-3-gallate in the treatment of women with vulvar intraepithelial neoplasia
  • Cohort, cross-sectional and prospective clinical studies in pre-invasive and invasive disease of the vulva and cervix, and high-grade serous ovarian cancer

Other activities

  • Member of the Birmingham Vulvar Neoplasia Study Group
  • Co-Chair of West Midlands vulval disease MDT

Publications

Yap, J. K., Fox, R., Leonard, S., Ganesan, R., Kehoe, S. T., Dawson, C. W., Woodman, C. B., and Luesley, D. M. (2016) Adjacent Lichen Sclerosis predicts local recurrence and second field tumour in women with vulvar squamous cell carcinoma. Gynecologic Oncology 142, 420-426 (Society White Paper)

Yap, J., O’Neill, D., Nagenthiran, S., Dawson, C., Luesley, D. Current insights into the aetiology, pathobiology and management of local disease recurrence in squamous cell carcinoma of the vulva: a review paper. British Journal of Obtetrics and Gynaecology (2017) Article in Press (DOI: 10.1111/1471-0528.14560)

Leonard, S., Pereira, M., Fox, R., Gordon, N., Yap, J., Kehoe, S., Luesley, D., Woodman, C., and Ganesan, R. (2016) Over-expression of DNMT3A predicts the risk of recurrent vulvar squamous cell carcinomas. Gynecologic Oncology

Yap, J. K., Baker, L. J., Balega, J. Z., Chan, K. K., and Luesley, D. M. (2011) Impact of improving outcome guidance in gynaecological cancer on squamous cell carcinoma of the vulva in the West Midlands, UK. J Obstet Gynaecol 31, 754-758

Yap, J. K., and Davies, M. (2007) Fertility preservation in female cancer survivors. J Obstet Gynaecol 27, 390-400

Gallos, I. D., Yap, J., Rajkhowa, M., Luesley, D. M., Coomarasamy, A., and Gupta, J. K. (2012) Regression, relapse, and live birth rates with fertility-sparing therapy for endometrial cancer and atypical complex endometrial hyperplasia: a systematic review and metaanalysis. American Journal of Obstetrics and Gynecology 207, 266 e261-212

Underwood, M., Yap, J. K., Elattar, A., Ganesan, R., Notghi, A., Crockett, C., and Luesley, D. M. (2013) The use of sentinel node sampling in vulval cancer. J Obstet Gynaecol 33, 892-897

Sundar, S., Wu, J., Hillaby, K., Yap, J., and Lilford, R. (2012) A systematic review evaluating the relationship between progression free survival and post progression survival in advanced ovarian cancer. Gynecologic Oncology 125, 493-499

Soo Hoo, S., Marriott, N., Houlton, A., Nevin, J., Balega, J., Singh, K., Yap, J., Sethuram, R., Elattar, A., Luesley, D., Kehoe, S., and Sundar, S. (2015) Patient-Reported Outcomes After Extensive (Ultraradical) Surgery for Ovarian Cancer: Results From a Prospective Longitudinal Feasibility Study. International Journal of Gynecological Cancer : official journal of the International Gynecological Cancer Society 25, 1599-1607