Dr Molly O'Reilly PhD

Dr Molly O'Reilly

Institute of Cardiovascular Sciences
Research Fellow

Contact details

Address
Room 139 - Institute of Biomedical Research
Medical School
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Molly O’Reilly is a Post-Doctoral Research Fellow in the Institute of Cardiovascular Sciences.

Her research investigates the ionic basis of arrhythmias, with a particular focus on understanding how hypoxia exposure causes cardiac electrical remodelling that affects susceptibility to the development of atrial fibrillation.

Qualifications

  • PhD in Neuroscience, University of Sussex (2018)
  • Associate Fellow of the Higher Education Academy (HEA), (2016)
  • Bsc (Hons) in Neuroscience with Cognitive Science, University of Sussex (2014)

Biography

Dr O’Reilly graduated with a first class Bsc honours degree in Neuroscience with Cognitive Science from the University of Sussex, in 2014.

Dr O’Reilly completed her PhD under the supervision of Professor Corné Kros and Professor Guy Richardson, in the School of Life Sciences at the University of Sussex. Here she studied the ototoxic effects of the aminoglycoside antibiotics, whilst identifying otoprotectant compounds and investigating their mechanism of action.

Dr O’Reilly currently works in the Translational Research on Heart Failure and Arrhythmia Cluster at the Institute of Cardiovascular Sciences, led by Professor Paulus Kirchhof and Dr Larissa Fabritz. The focus of her research is on how acute and chronic hypoxia contributes to atrial fibrillation susceptibility by inducing cardiac electrical remodelling.

Teaching

  • MBChB Year 2 Cardiovascular System (2018 – Present)

Research

Dr O’Reilly has research interests in cardiovascular physiology, investigating the ionic basis of arrhythmias with a particular emphasis on understanding how exposure to hypoxia induces atrial electrical remodelling that enhances susceptibility to the development of atrial fibrillation. 

Research Groups and Centres

Institute of Cardiovascular Sciences

Translational Research on Heart Failure and Arrhythmia 

Publications

O’Reilly M, Young L, Kirkwood NK, Richardson GP, Kros CJ and Moore AL Gentamicin Affects the Bioenergetics of Isolated Mitochondria and Collapses the Mitochondrial Membrane Potential in Cochlear Sensory Hair Cells. Front. Cell. Neurosci. 13:416. doi: 10.3389/fncel.2019.00416 (2019) Impact factor: 3.9

O'Reilly M, Kirkwood NK, Kenyon EJ, Huckvale R, Cantillon DM1, Waddell SJ1, Ward SE2, Richardson GP, Kros CJ, Derudas M. Design, synthesis and biological evaluation of a new series of carvedilol derivatives that protect sensory hair cells from aminoglycoside-induced damage by blocking the mechano-electrical transducer channel. Journal of Medicinal Chemistry. (2019) Impact factor: 6.2

Jeong M, O'Reilly M, Kirkwood NK, Al-Aama J, Lako M, Kros CJ and Armstrong L. Generating inner ear organoids containing putative cochlear hair cells from human pluripotent stem cells. Cell Death & Disease 922(9). (2018). 2041-4889. Impact factor: 5.638

Kenyon EJ, Kirkwood NK, Kitcher SR, O’Reilly M, Derudas M, Cantillon DM., et al.  Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death. JCI Insight (2017). 2:96773. Impact factor: 6.014

Kirkwood NK, O’Reilly M, Derudas M, Kenyon EJ, Huckvale R, Van Netten SM, et al. d-Tubocurarine and berbamine: alkaloids that are permeant blockers of the hair cell’s mechano-electrical transducer channel and protect from aminoglycoside toxicity. Front. Cell. (2017). Neurosci. 11:262 Impact factor: 4.555

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