Recent publications
Article
Alenazy, F, Harbi, M, Kavanagh, D, Price, J, Brady, P, Hargreaves, O, Harrison, P, Slater, A, Tiwari, A, Nicolson, P, Connolly, D, Kirchhof, P, Kalia, N, Jandrot-Perrus, M, Mangin, PH, Watson, S & Thomas, MR 2023, 'Amplified inhibition of atherosclerotic plaque-induced platelet activation by glenzocimab with dual antiplatelet therapy JTH', Journal of thrombosis and haemostasis : JTH. https://doi.org/10.1016/j.jtha.2023.07.018
Damaskinaki, F-N, Jooss, NJ, Martin, EM, Clark, JC, Thomas, MR, Poulter, NS, Emsley, J, Kellam, B, Watson, SP & Slater, A 2023, 'Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization', Journal of thrombosis and haemostasis : JTH, vol. 21, no. 2, pp. 317-328. https://doi.org/10.1016/j.jtha.2022.11.002
Kardeby, C, Evans, A, Campos, J, Al-Wahaibi, AM, Smith, C, Slater, A, Slater, E, Severin, S, Brill, A, Pejler, G, Sun, Y & Watson, S 2023, 'Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3Kβ', Journal of Thrombosis and Haemostasis, vol. 21, no. 1, pp. 101-116. https://doi.org/10.1016/j.jtha.2022.10.008
Jooss, NJ, Smith, CW, Slater, A, Montague, SJ, Di, Y, O'shea, C, Thomas, MR, Henskens, YMC, Heemskerk, JWM, Watson, SP & Poulter, NS 2022, 'Anti-GPVI nanobody blocks collagen- and atherosclerotic plaque-induced GPVI clustering, signaling and thrombus formation', Journal of Thrombosis and Haemostasis, vol. 20, no. 11, pp. 2617-2631. https://doi.org/10.1111/jth.15836
Maqsood, Z, Clark, JC, Martin, EM, Cheung, YFH, Morán, LA, Watson, SET, Pike, JA, Di, Y, Poulter, NS, Slater, A, Lange, BMH, Nieswandt, B, Eble, JA, Tomlinson, MG, Owen, DM, Stegner, D, Bridge, LJ, Wierling, C & Watson, SP 2022, 'Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins', PLoS Computational Biology, vol. 18, no. 11, e1010708. https://doi.org/10.1371/journal.pcbi.1010708
Perrella, G, Montague, SJ, Brown, HC, Garcia Quintanilla, L, Slater, A, Stegner, D, Thomas, M, Heemskerk, JWM & Watson, SP 2022, 'Role of Tyrosine Kinase Syk in Thrombus Stabilisation at High Shear', International Journal of Molecular Sciences, vol. 23, no. 1, 493. https://doi.org/10.3390/ijms23010493
Colicchia, M, Schrottmaier, WC, Perrella, G, Reyat, JS, Begum, J, Slater, A, Price, J, Clark, JC, Zhi, Z, Simpson, M, Bourne, J, Poulter, NS, Khan, AO, Nicolson, PLR, Pugh, MR, Harrison, P, Iqbal, AJ, Rainger, GE, Watson, SP, Thomas, MR, Mutch, NJ, Assinger, A & Rayes, J 2022, 'S100A8/A9 drives the formation of procoagulant platelets through GPIbα', Blood. https://doi.org/10.1182/blood.2021014966
Billiald, P, Slater, A, Welin, M, Clark, J, Loyau, S, Pugnière, M, Jiacomini , IG, Rose, N, Lebozec, K, Toledano, E, François, D, Watson, S & Jandrot-Perrus, M 2022, 'Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition', Blood Advances. https://doi.org/10.1182/bloodadvances.2022007863
Clark, J, Neagoe, RAI, Zuidscherwoude, M, Kavanagh, D, Slater, A, Martin, E, Soave, M, Stegner, D, Nieswandt, B, Poulter, N, Hummert, J, Herten, D-P, Tomlinson, M, Hill, SJ & Watson, S 2021, 'Evidence that GPVI is expressed as a mixture of monomers and dimers, and that the D2 domain is not essential for GPVI activation: GPVI dimerisation is not critical for ligand binding', Thrombosis and Haemostasis, vol. 2021, no. 00, pp. 1-26. https://doi.org/10.1055/a-1401-5014
Xu, R-G, Gauer, J, Baker, S, Slater, A, Martin, E, McPherson, H, Duval, C, Manfield, I, Bonna, A, Watson, S & Ariëns, RAS 2021, 'GPVI (Glycoprotein VI) interaction with fibrinogen is mediated by avidity and the fibrinogen αC-region', Arteriosclerosis Thrombosis and Vascular Biology, vol. 41, no. 3, pp. 1092-1104. https://doi.org/10.1161/ATVBAHA.120.315030
Zhi, Z, Jooss, NJ, Sun, Y, Colicchia, M, Slater, A, Moran, LA, Cheung, HYF, Di, Y, Rayes, J, Poulter, NS, Watson, SP & Iqbal, AJ 2021, 'Galectin-9 activates platelet ITAM receptors glycoprotein VI and C-type lectin-like receptor-2', Journal of thrombosis and haemostasis : JTH. https://doi.org/10.1111/jth.15625
Montague, SJ, Patel, P, Martin, EM, Slater, A, Quintanilla, LG, Perrella, G, Kardeby, C, Nagy, M, Mezzano, D, Mendes, PM & Watson, SP 2021, 'Platelet activation by charged ligands and nanoparticles: platelet glycoprotein receptors as pattern recognition receptors', Platelets, vol. 32, no. 8, pp. 1-13. https://doi.org/10.1080/09537104.2021.1945571
Slater, A, Di, Y, Clark, J, Jooss, N, Martin, E, Alenazy, F, Thomas, MR, Ariëns, RAS, Herr, AB, Poulter, N, Emsley, J & Watson, S 2021, 'Structural characterisation of a novel GPVI nanobody-complex reveals a biologically active domain-swapped GPVI dimer', Blood, vol. 2021, no. 00, pp. 1-20. https://doi.org/10.1182/blood.2020009440
Comment/debate
Slater, A & Jandrot-Perrus, M 2022, 'GPVI and collagen: the final word?', Blood, vol. 139, no. 20, pp. 3005–3007. https://doi.org/10.1182/blood.2022015962
Letter
Bourne, J, Colicchia, M, Di, Y, Martin, E, Slater, A, Roumenina, LT, Dimitrov, JD, Watson, S & Rayes, J 2021, 'Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2', Haematologica, vol. 106, no. 2, pp. 626-629. https://doi.org/10.3324/haematol.2020.246488
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