Dr Caroline Kardeby

Caroline Kardeby

Institute of Cardiovascular Sciences
Marie Skłodowska-Curie Research Fellow

Contact details

Address
Institute of Cardiovascular Sciences
Room 119, Floor 1, Institute of Biomedical Research
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Caroline Kardeby joined the Birmingham Platelet Research Group and Institute of Cardiovascular Sciences as a British Heart Foundation Research Fellow 2019. In 2020, she started her position as a Marie Skłodowska-Curie Research Fellow and began working on her project titled PAELLA: Platelet Endothelial Aggregation Receptor 1. Dr Kardeby’s research is in the field of platelet receptor signalling and the role of platelets in inflammation and immunity. She has a special interest in protein-carbohydrate interactions.

Qualifications

  • PhD in Medicine, specialisation Biomedicine, Örebro University, Sweden, 2019
  • MSc in Medicine, Örebro University, Sweden 2013
  • BSc in Biomedical Laboratory Science, Uppsala University, Sweden, 2011
  • BSc in Medicine, Uppsala University, Sweden, 2011

Biography

Dr Kardeby graduated in Biomedical Laboratory Science and Medicine from Uppsala University, she later studied for a master degree at Örebro University from where she also holds a PhD in medicine with specialisation in biomedicine.

Already while working on her master thesis Dr Kardeby became interested in platelets and their role in haemostasis. In her doctoral thesis titled “Studies of platelet signalling and endothelial cell responses using unique synthetic drugs” Dr Kardeby identified the Platelet Endothelial Aggregation Receptor 1 as a receptor target for sulfated fucose-based polysaccharides.

Today Dr Kardeby holds a Marie Skłodowska-Curie Actions Individual Fellowship, funded by the European Commission and the Horizon 2020 programme. Her project is titled PAELLA: Platelet Endothelial Aggregation Receptor 1. In her project, Dr Kardeby aims to identify the physiological of the receptor with a focus on platelets in inflammation and immunity.

Research

Dr Kardeby is currently the principal investigator of the MSCA-IF project PAELLA: Platelet Endothelial Aggregation Receptor 1, a receptor which is also known as PEAR1. Studies have shown that genetic variants of PEAR1 are strongly associated with cardiovascular disease. Earlier studies by Dr Kardeby has shown that PEAR1 interacts with sulfated polysaccharides and can cause strong platelet aggregation. However, the physiological role of the receptor is yet to be established.

The aim of project PAELLA is to identify the physiological role of the receptor in platelets and endothelial cells.

By uncovering the role of the Platelet Endothelial Aggregation Receptor 1 we may find new treatment strategies to combat thrombosis.

Some of Dr Kardeby’s research interests include:

  • Platelet signalling in health and disease
  • Carbohydrate-protein interactions
  • The role of platelets in inflammation and immunity

Research Groups and Centres

Other activities

Dr Kardeby is the current chairperson of the Marie Curie Association at the University of Birmingham

Publications

Kardeby C, Damaskinaki FN, Sun Y, Watson SP Is the endogenous ligand for PEAR1 a proteoglycan: clues from the sea. Platelets. 2020. [Accepted for publication]

Bergemalm D, Ramstrom, Kardeby C, Hultenby K, Gothlin Eremo A, Sihlbom C, Bergstrom J, Palmblad J, Astrom M. Platelet proteome and function in X-linked thrombocytopenia with thalassemia and in silico comparisons with gray platelet syndrome. Haematol. 2020. [Epub ahead of print]

Ljungberg, LU, Zegeye MM, Kardeby C, Fälker K, Repsilber D, Sirsjö A. Global Transcriptional Profiling Reveals Novel Autocrine Functions of Interleukin 6 in Human Vascular Endothelial Cells. Mediators of Inflamm. 2020. 4623107

Kardeby C, Paramel GV, Pournara D, Fotopoulou T, Sirsjö A, Koufaki M, Fransén K, Grenegård M. A novel purine analogue bearing nitrate ester prevents platelet activation by ROCK activity inhibition. Eur J Pharmacol. 2019. 857:172428.

Fälker K, Ljungberg LU, Kardeby C, Lindkvist M, Sirsjö A, Grenegård M. Adrenoceptor α2A signalling repels the inhibitory effects of synchronous cyclic nucleotide-elevation on thrombin-induced human platelet activation. Cell Signal. 2019. 59:96-109.

Kardeby C, Fälker K, Haining EJ, Criel M, Lindkvist M, Barroso R, Påhlsson P, Ljungberg LU, Tengelius M, Rainger GE, Watson S, Eble JA, Hoylaerts MF, Emsley J, Konradsson P, Watson SP, Sun Y, Genegård M. Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα. Blood Adv. 2019. 3:275-287.

Tengdelius M, Kardeby C, Fälker K, Griffith M, Påhlsson P, Konradsson P, Grenegård M. Fucoidan-Mimetic Glycopolymers as Tools for Studying Molecular and Cellular Responses in Human Blood Platelets.Macromol Biosci. 2017. 17:1600257

Koskela von Sydow A, Janbaz C, Kardeby C, Repsilber D, Ivarsson M. IL-1α Counteract TGF-β Regulated Genes and Pathways in Human Fibroblasts.J Cell Biochem. 2016. 117:1622-32.

View all publications in research portal