Professor Alvin W Nienow FREng, BSc(Eng), PhD, DSc, Dhc, CEng, CSci, MAIChE, FIChemE, FHEA, HonMCzSChE

Professor Alvin W Nienow

School of Chemical Engineering
Emeritus Professor of Biochemical Engineering

Contact details

Address
School of Chemical Engineering
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Professor Nienow was the first Professor of Biochemical Engineering (now Emeritus) in­ the School of Chemical Engineering at the University of Birmingham and Director of Biochemical Engineering from 1989 to 1999. He is also a Visiting Professor at both Loughborough and Aston Universities. He has honorary doctorates from Loughborough and the West Pomeranian University, a DSc from University College London and is a Fellow of the Royal Academy of Engineering and the Institution of Chemical Engineers. He has held over 80 grants, published over 400 refereed papers and been cited more than 5,000 times.

  • Fellow of the Royal Academy of Engineering, 1984
  • Honorary Member of the Czech Society of Chemical Engineering, 2008
  • Fellow of the Institution of Chemical Engineers, 1981
  • Member of the American Institute of Chemical Engineers, 2000
  • Chartered Engineer, 1982
  • Chartered Scientist, 2003

 Awards

  • The Moulton Medal; Institution of Chemical Engineers for paper, “Particle-Gas-Liquid Mixing in Stirred Vessels (Part I to IV)”, Chemical Engineering Research and Design (with C.M. Chapman, M. Cooke and J.C. Middleton) for “the most notable contribution during 1983 to their published records”, 1984
  • The Jan E Purkyne Medal; The Academy of Sciences of the Czech Republic for services to Czech Chemical Engineering, 1993
  • Eminent Speaker; Institution of Engineers (Australia) Chemical Colleges, 1999
  • The Donald Medal; Institution of Chemical Engineers Subject Group on Biochemical Engineering for "lifetime contribution", 2000
  • Lifetime Recognition Award”; European Federation of Chemical Engineers for “Significant Lifetime Contribution to Mixing Research and Practice”, 2003
  • Special Issue, Transactions of the Institution of Chemical Engineers, Part A, published in his honour on the occasion of his retirement, September 2004
  • Honorary Life Chairman, Institution of Chemical Engineers Fluid Mixing Processes Subject Group, Sept., 2004
  • Honorary Member of the Czech Society of Chemical Engineering, 2008
  • Medal no 441 of Szczecin University of Technology for ‘Special Contributions’ (as part of its celebrations as it combined with the Agricultural Academy of Szczecin to form the West-Pomeranian University of Technology), 2008
  • Plenary Lecture Award, Pharmaceutical Group, American Institute of Chemical Engineers, 2009
  • Doctor honoris causa, West Pomeranian University of Technology, Szczecin, Poland, 2010
  • Paper, "X-ray Studies of Cavern Sizes and Mixing Performance with Fluids Possessing a Yield Stress", (with TP Elson and DJ Cheesman), Chem. Eng. Sci., 41, (1986), 2555-2562 voted one of the 21 most influential papers on mixing by the AIChE’s North American Mixing Forum, 2011
  • Doctor honoris causa, Loughborough University, UK, 2012 
  • Peter Dunnill Award for Outstanding Contribution to UK bioprocessing, 2018

Qualifications

  • BSc (Eng) in Chemical Engineering, University College London
  • PhD, University College London
  • DSc (Eng), University College London

Biography

Professor Nienow was awarded the Peter Dunnill Award from bioProcessUK, in conjunction with the BioIndustry Association (BIA), in November, 2018. 

Employment history

  • 1963 – 1980: Lecturer/Senior Lecturer,  University College London
  • 1980 – 1989: Professor of Chemical Engineering, The University of Birmingham
  • 1989 – 2004: Professor of Biochemical Engineering
  • 2004 – present: Emeritus Professor of Biochemical Engineering

Research

Research area

Mixing and Transport Phenomena in Stirred Reactors and Bioreactors.

Other activities

  • Visiting Professor of Biochemical Engineering, Loughborough University; 2009 -
  • Visiting Professor of Biochemical Engineering, Aston University; 2016 -

Publications

Selected Recent Publications


“X-ray Studies of Cavern Sizes and Mixing Performance with Fluids Possessing a Yield Stress", (with TP Elson and DJ Cheesman), Chem. Eng. Sci., 41, (1986), 2555-2562 voted one of the 21 most influential papers on mixing by the AIChE’s North American Mixing Forum, 2011

Harnby, N., Edwards, M.F. and Nienow, A.W., (Eds), "Mixing in the Process Industries", 2nd Edition (in paperback), Butterworth Heinemann, London, 1997, 414 pages

"Hydrodynamics of Stirred Bioreactors", in "Fluid Mechanics Problems in Biotechnology", R. Pohorecki, ed., App.Mech.Rev., 51, (1998), 3-32

"Aeration-Biotechnology", Kirk Othmer Encyclopedia of Chemical Technology, 5th Edition, Wiley, New York, on-line edition 2003

“Blending of Miscible Liquids” (with R. K. Grenville), in “Handbook of Industrial Mixing; Science and Practice”, (Eds. E.L Paul, V.A Atiemo-Obeng and S.M. Kresta), Wiley-Interscience, N.Y., 2003, Ch. 9, pp 507-539

”Mixing in the Fermentation and Cell Culture Industries” (with A. Amanullah and B.C. Buckland), in “Handbook of Industrial Mixing; Science and Practice”, (Eds. E.L Paul, V.A Atiemo-Obeng and S.M. Kresta), Wiley-Interscience, N.Y., 2003, Ch. 18, pp 1071-1157

“A Vessel for Mixing a Cell Lysate”, (with A.G. Hitchcock and G.L. Riley);. European patent 1159062, 12th November 2003, 14 pages

“Further Studies Related to the Scale-up of High Cell Density Escherichia coli Fed-batch Fermentations: the Additional Effect of a Changing Micro-environment When Using Aqueous Ammonia to Control pH”, (with H. Onyeaka and C J. Hewitt), Biotechnol. Bioeng.,84, (2003), 474 –484

“Break-up, Coalescence and Catastrophic Phase Inversion in Turbulent Contactors”, Advances in Colloid and Interface Science, 108-109C, (2004), 95-103

“The Versatility of Up-Pumping Hydrofoil Agitators”, (with W. Bujalski), Chem. Eng. Res. Des. (Trans. I. Chem. E, Part A), 82, (2004), 1073-1081

“The Suspension of Microcarriers for Cell Culture with Axial Flow Impellers”, (with S. Ibrahim), Chem. Eng. Res. Des. (Trans. I. Chem. E, Part A), 82, (2004), 1082-1088

 “Intensifying Micromixing in a Semi-Batch Reactor Using a Rushton Turbine”, (with M. Assirelli, W. Bujalski, A. Eaglesham), Chem. Eng. Sci., 60, (2005), 2333-2339

“Reactor Engineering in Large Scale Animal Cell Culture”, Cytotechnology, 50, (2006), 9-33

“A Comparison of High Cell Density Fed-Batch Fermentations Involving Both Induced and Non-Induced Recombinant Escherichia Coli Under Well-Mixed Small-Scale and Simulated Poorly-Mixed Large-Scale Conditions” (with C J. Hewitt, H Onyeaka, G Lewis and I W. Taylor), Biotechnol. Bioeng., 96, (2007), 495–505

“Simultaneous Measurement of In-situ Bubble Size and Reaction Rates with a Heterogeneous Catalytic Hydrogenation Reaction” (with B. Hu, R.P. Fishwick, A.W. Pacek, J.M.Winterbottom, J.Wood and E.H. Stitt), Chem. Eng. Sci. 62, (2007), 5392 – 5396

“The Scale-Up of Microbial Batch and Fed-Batch Fermentation Processes”, (with C. J. Hewitt), (Eds A. L. Laskin, S. Sariaslani, G. M. Gadd), Elsevier/Academic Press, (ISBN:978-0-12-373669-7); Adv. in Applied Microbiology, 62, (2007), 105-136.

“Macro- and Micro-Mixing Studies in an Unbaffled Vessel Agitated by a Rushton Turbine”, (with M. Assirelli; W. Bujalski; A. Eaglesham), Chem. Eng. Sci, 63, (2008), 35– 46

“Mixing Studies in a Model Aerated Bioreactor Equipped with an Up- or a Down-Pumping 'Elephant Ear' Agitator; Power, Hold-up and Aerated Flow Field Measurements”, (with H. Zhu, W Bujalski and M. J. H. Simmons), Chem. Eng. Res. Des. (Trans. I. Chem. E., Part A) 87, (2009), 307-317

“Use of angle resolved PIV to estimate local specific energy dissipation rates for up- and down-pumping pitched blade agitators in a stirred tank”, (with A. Gabriele and M.J.H. Simmons), Chem. Eng. Sci., 64, (2009), 126-143

“Using Positron Emission Particle Tracking (PEPT) to Study Mixing in Stirred Vessels: Validation and Tackling Unsolved Problems in Opaque Systems”, (with M. Barigou, F. Chiti, P. Pianko-Oprych, A. Guida, L. Adams,X.  Fan and D. J. Parker), J. Chem. Eng., Japan, 42, (2009), 839 -846

“Stirred Tank Reactors”. In: Ullmann's Encyclopedia of Industrial Chemistry (7th Edition), Wiley-VCH Verlag GmbH & Co. Weinheim, Germany, CD and Online Posting Date: January 15, 2010; DOI: 10.1002/14356007.b04_167.pub2

“Impeller Selection: Animal Cell Culture”. In: Encyclopedia of Industrial Biotechnology, John Wiley & Sons, Inc., Hoboken, NJ, USA, DOI: 10.1002/9780470054581.eib636 Online Posting Date: April 15, 2010; Vol. 5, pp 2959-2971

“Scale-Up, Stirred Tank Reactors”.  In: Encyclopedia of Industrial Biotechnology, John Wiley & Sons, Inc., Hoboken, NJ, USA, DOI: 10.1002/9780470054581.eib535 Online Posting Date: April 15, 2010; Vol. 7, pp 4328 – 4341

“PEPT Measurements of Solid–Liquid Flow Field and Spatial Phase Distribution in Concentrated Monodisperse Stirred Suspensions”, (with A. Guida and M. Barigou), Chem. Eng. Sci., 65, (2010), 1905-2264

“Shannon Entropy for Local and Global Description of Mixing by Lagrangian Particle Tracking”, (with  A. Guida and M. Barigou), Chem. Eng. Sci., 65, (2010), 2865-2883

“The Effects of the Azimuthal Position of the Measurement Plane on the Flow Parameters Determined by PIV within a Stirred Vessel”, (with A. Guida and M. Barigou), Chem. Eng. Sci., 65, (2010), 2454-2463

“Micromixing in Two-phase (g-l and s-l) Systems in a Stirred Vessel”, (with J. Hofinger, R. W. Sharpe, W. Bujalski, S.  Bakalis, M. Assirelli and A. Eaglesham), Can. J. Chem. Eng., 89, (2011), 1029-1039

“Using Positron Emission Particle Tracking (PEPT) to Study the Turbulent Flow in a Baffled Vessel Agitated by a Rushton Turbine: Improving Data Treatment and Validation”, (with F. Chiti, S. Bakalis, W. Bujalski, M. Barigou and A. Eaglesham), Chem. Eng. Res. Des., (Trans. I Chem Eng. Part A), 89, (2011), 1947 -1960

"Scale-Down/Scale-up Studies Leading to Improved Commercial Beer Fermentation", (with M. Nordkvist and C. J. Boulton), Biotechnol. J., 6, (2011), 911 – 925

“Expansion of Human Mesenchymal Stem Cells on Microcarriers”, (with C. J. Hewitt, K. Lee,  R. J. Thomas, M. Smith and C. R. Thomas), Biotechnol. Letters, 33, (2011), 2325-2335

"Further Studies of Micromixing: Scale-up, Baffling and Feed Pipe Backmixing", (with M. Assirelli and S. P. Lee), J. Chem. Eng., Japan, 44, (2011), 901 -907

“Lagrangian Tools for the Analysis of Mixing in Single- and Multi-Phase Flow Systems” (with A. Guida and M. Barigou), AIChE Journal, 58, (2012), 31 – 45

“The Large Scale Expansion and Exploitation of Pluripotent Stem Cells for Regenerative Medicine Purposes: Beyond the T-Flask”, (with A. J. Want, C. J. Hewitt and K. Coopman), Regen. Med., 7, (2012), 71–84

“On the Generation of Hydrogen Gas during the Catalytic Oxidation of Sodium Lignosulphonate to Vanillin: Initial Results”, (with P. Ding, M. Garrett, Ø. Loe and A.W. Pacek), Ind. Eng. Chem. Res., 51, (2012),184-188

“A Quantitative Approach for Understanding Small-Scale Human Mesenchymal Stem Cell Culture – Implications for Large-Scale Bioprocess Development”, (with Q. A. Rafiq, K. Coopman and C.J. Hewitt), Biotechnol. J., 8, (2013), 459-471

“Culture of Human Mesenchymal Stem Cells on Microcarriers in a 5 L Stirred-Tank Bioreactor”. (with Q. A. Rafiq, K. M. Brosnan, K. Coopman and C.J. Hewitt), Biotechnol. Lett., 35, (2013):1233-1245

“The Physical Characterisation of a Microscale Parallel Bioreactor Platform with an Industrial CHO Cell Line Expressing an IgG4”, (with C.D. Rielly, K. M. Brosnan, N. Bargh, K. Lee, K. Coopman and C.J. Hewitt), Biochem. Eng., J., 76, (2013), 25 – 36
 
“Scale-Down Studies for Assessing the Impact of Different Stress Parameters on Growth and Product Quality during Animal Cell Culture”, (with W. H. Scott, C. J. Hewitt, C. R. Thomas, G. Lewis, A. Amanullah, R. Kiss and S. J. Meier), Chem. Eng. Res. Des., 91, (2013), 2265–2274

“Catalytic Conversion of Sodium Lignosulphonate to Vanillin – Engineering Aspects. Part 1 Effect of Processing Conditions on Vanillin Yield and Selectivity", (with A. W. Pacek, P. Ding, M. Garrett and G. Sheldrake), Ind. Eng. Chem. Research, 52 (2013), 8361-8372

“A Potentially Scalable Method for the Harvesting of hMSCs from Microcarriers”, (with Q. A. Rafiq, K.  Coopman and C.J. Hewitt), Biochem. Eng J., 85 (2014) 79–88

“Stirring and Stirred Tank Reactors”, Chem. Ing Tech., 86, (2014) 2063 – 2074

“The Translation of Cell-based Therapies: Clinical Landscape and Manufacturing Challenges”, (with T. R. J. Heathman, M. J. McCall, K. Coopman, B. Kara and C. J. Hewitt), Regen. Med. 10, (2015) 49–64

“Mass Transfer and Mixing Across the Scales in Animal Cell Culture”, in Animal Cell Culture, Cell Engineering 9, (Ed. M. Al-Rubeai), Springer International, 2015, Chapter 5, pp 137 – 169

“Expansion, Harvest and Cryopreservation of Human Mesenchymal Stem Cells in a Serum-Free Microcarrier Process”, (with T. R. J. Heathman, V. A. M Glyn, A. Picken, Q. A. Rafiq, K. Coopman, B. Kara and C. J. Hewitt), Biotech. Bioeng., 112, (2015), 1696-1707

“Mixing Issues in Crystallization and Precipitation Operations”, (with E. L. Paul); In “Advances in Industrial Mixing: A Companion to the Handbook of Industrial Mixing”, (Eds., S. M. Kresta, A. W. Etchells III, D. S. Dickey and V. Atiemo-Obeng), Wiley-Interscience, New York, USA, Chapter 25, 2016, pp. 665-728

“Systematic microcarrier screening and agitated culture conditions improve human mesenchymal stem cell yield in bioreactors”, (with Q.A. Rafiq, K. Coopman and C.J. Hewitt), Biotechnology J., 11, (2016)

“Characterisation of Human Mesenchymal Stem Cells from Multiple Donors and the Implications for Large Scale Bioprocess Development”, (with T. R. J. Heathman, Q. A. Rafiq, A. K. C. Chan, K. Coopman, B. Kara and C. J. Hewitt), Biochem. Eng. J., 108, (2016), 14–23

"Aeration-Biotechnology", Kirk Othmer Encyclopedia of Chemical Technology, 6th Edition, Wiley, New York, 2015, Wiley, Published Online : 16 Dec 2015; DOI: 10.1002/0471238961.020915204090514.a01.pub3

“Agitation Conditions for the Culture and Detachment of hMSCs from Microcarriers in Multiple Bioreactor Platforms”, (with C.J. Hewitt, T.R.J. Heathman, V.A.M. Glyn, G.N. Fonte, M.P. Hanga, K. Coopman, Q.A. Rafiq), Biochem. Eng. J., 108, (2016), 24–29

“Serum-Free Process Development: Improving the Yield and Consistency of Human Mesenchymal Stem Cell Production”, (with T.R.J. Heathman, A. Stolzing, C. Fabian, Q.A. Rafiq, K. Coopman, B. Kara and C.J. Hewitt), Cytotherapy, 17, (2015), 1524 – 1535

"Mixing Theory for Culture and Harvest in Bioreactors of Human Mesenchymal Stem Cells on Microcarriers", (with Q.A. Rafiq, T.R.J. Heathman, K. Coopman and C.J. Hewitt), Theoretical Foundation of Chemical Engineering, 50, (2016), 895 - 900

“Scalability and Process Transfer of Mesenchymal Stromal Cell Production From Monolayer to Microcarrier Culture Using Human Platelet Lysate”, (with T.R.J. Heathman, A. Stolzing, C. Fabian, Q. A. Rafiq,  K. Coopman,  B. Kara,  C.J. Hewitt), Cytotherapy, 18, (2016) 523-535

“Bioreactor Engineering Fundamentals for Stem Cell Manufacturing”, (with K. Coopman, T. R. J. Heathman, Q. A. Rafiq and C. J. Hewitt),  in “Stem Cell Manufacturing”, (Eds. J.M.S. Cabral, C.L. de Silva, L. G. Chase and M. M. Diogo), Elsevier Science, Cambridge, USA;  Chapter 3, pp  43 – 76, 2016;  ISBN 978-0-444-63265-4

“Design and Performance of Single-Use, Stirred-Tank Bioreactors”, (with B. Isailovic and T. A. Barrett), BioProcess Int., 14 (10), (2016), 12-21

“Engineering Considerations on the Use of Liquid/liquid Two phase Systems as a Cell Culture Platform”, (with H. Murasiewicz, M. P. Hanga, K. Coopman, C. J. Hewitt and A. W. Pacek), J. Chem. Tech. & Biotech., 92, (2017), 1690–1698

“Expansion of Bone Marrow Derived Human Mesenchymal Stem/Stromal Cells (hMSC) Using a Two phase Liquid/Liquid System”, (with M. P. Hanga, H. Murasiewicz, A. W. Pacek, K. Coopman and C. J. Hewitt), J. Chem. Tech. & Biotech., 92, (2017), 1577–1589

“Scale-up Agitation Criteria for Trichoderma reesei Fermentation”, (with N. Hardy, F. Augier, C. Beal, F.Ben Chaabane), Chem. Eng. Sci., 172, (2017) 158-168
   
“Process development of human multipotent stromal cell microcarrier culture using an automated high – throughput microbioreactor”, (with Q. A. Rafiq, M.P. Hanga, T.R.J. Heathman, K.  Coopman, D.J. Williams and C.J. Hewitt), Biotech. Bioeng., 114, (2017), 2253 -2266

“Qualitative and quantitative demonstration of bead-to-bead transfer with bone marrow-derived human mesenchymal stem cells on microcarriers: utilising the phenomenon to improve culture performance”, (with Q.A. Rafiq, S. Ruck, M. P. Hanga, T. R. J. Heathman, K. Coopman, D. J. Williams and C. J. Hewitt), Biochem. Eng. J., 135, (2018) 11–21

“Agitation and aeration of stirred-bioreactors for the microcarrier culture of human mesenchymal stem cells and potential implications for large-scale bioprocess development”, (with T.R.J. Heathman, Q.A. Rafiq, K. Coopman, B. Kara and C.J. Hewitt), Biochem. Eng. J., 136, (2018), 9–17

“Development of a process control strategy for the serum-free microcarrier expansion of human mesenchymal stem cells towards cost-effective and commercially viable manufacturing”, (with T.R.J. Heathman, Q.A. Rafiq, K. Coopman, B. Kara and C.J. Hewitt), Biochem. Eng. J., 141, (2019) 200-209