Dr Ben Scheven PhD FHEA

Dr Ben Scheven

School of Dentistry
Senior Lecturer in Oral Cell Biology

Contact details

Address
The School of Dentistry
5 Mill Pool Way
Edgbaston
Birmingham
B5 7EG
United Kingdom

Dr Ben Scheven is Senior Lecturer in Oral Cell Biology and has an established track record in the cell biology of bone and dental tissues in health and disease. His current research centres around the role and application of mesenchymal and dental stem cells in tissue repair and regeneration, nerve repair and neuronal cell differentiation and therapeutic ultrasound.    

Qualifications

  • Fellow of the Higher Education Academy (2011)
  • PgCert LTHE (2011)
  • PhD, University of Leiden (1986)
  • MSc Biology, University of Leiden (1982)

 

Teaching

  • BDS
  • BMedSc.
  • MRes.
  • MOrth.

Postgraduate supervision

Dr Scheven currently supervises doctoral research in the following areas:

Biological effects and therapeutic potential of ultrasound
Regulation of mesenchymal cells by neurotrophic factors
Stem cell isolation from adipose tissue for dental tissue engineering
Neurogenic potential of dental pulp: isolation and culture of neuronal stem cells from dental tissues
Mesenchymal stem cells for craniofacial tissue regeneration

Other activities

  • Lead of Oral Biology, Microbiology and Immunology module.
  • Head of BDS Elective Studies Programme
  • Member of Curriculum Development Committee, School of Dentistry
  • Member of Postgraduate Committee, School of Dentistry
  • External examiner of Oral Biology and Y2 of BDS programme (Years 1 and 2), University of Bristol
  • Member of management committee and councillor of the Association of Science Educators in Dentistry (ASEiD), formerly the Association of Basic Science Teachers in Dentistry (ABSTD).
  • Committee member / councillor of Mineralised Tissue Research Group (MINTIG) of the British Society for Dental Research
  • Frequent reviewer of scientific papers submitted to various international scientific journals and research project grant applications

Publications

Recent publications

Article

Sultan Mohamed Abd Elhamed, N & Scheven, B 2021, 'Dental pulp stem cells stimulate neuronal differentiation of PC-12 cells', Neural Regeneration Research, vol. 16, no. 9, pp. 1821-1828. https://doi.org/10.4103/1673-5374.306089

Sultan Mohamed Abd Elhamed, N & Scheven, B 2021, 'Exploring the potential application of dental pulp stem cells in neuroregenerative medicine', Neural Regeneration Research. <http://www.nrronline.org/>

Gleneadie, HJ, Baker, AH, Batis, N, Bryant, J, Jiang, Y, Clokie, SJH, Mehanna, H, Garcia, P, Gendoo, DMA, Roberts, S, Burley, M, Molinolo, AA, Gutkind, JS, Scheven, BA, Cooper, PR, Parish, JL, Khanim, FL & Wiench, M 2021, 'The anti-tumour activity of DNA methylation inhibitor 5-aza-2′-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress', Cancer Letters, vol. 501, pp. 172-186. https://doi.org/10.1016/j.canlet.2020.12.029

Grawish, M, Saeed, M, Sultan, N & Scheven, B 2021, 'Therapeutic applications of dental pulp stem cells in regenerating dental, periodontal and oral-related structures', World Journal of Meta-Analysis, vol. 9, no. 2, pp. 176-192. https://doi.org/10.13105/wjma.v9.i2.176

Bennett, JH, Beeley, JA, Anderson, P, Belfield, L, Brand, H, Didilescu, A, Dymock, D, Guven, Y, Hector, MP, Holbrook, P, Jayashinge, JAP, O'sullivan, J, Riggio, M, Roger‐leroi, V, Scheven, B, Sloan, AJ, K.vandamme & Manzanares, MC 2020, 'A core curriculum in the biological and biomedical sciences for dentistry', European Journal of Dental Education. https://doi.org/10.1111/eje.12518

Sultan Mohamed Abd Elhamed, N, Amin, LE, Zaher, AR, Grawish, ME & Scheven, B 2020, 'Neurotrophic effects of dental pulp stem cells on trigeminal neuronal cells', Scientific Reports, vol. 10, 19694, pp. 1-13. https://doi.org/10.1038/s41598-020-76684-0

Sultan, N, Amin, LE, Zaher, AR, Scheven, BA & Grawish, ME 2019, 'Dental pulp stem cells: Novel cell-based and cell-free therapy for peripheral nerve repair', World Journal of Stomatology, vol. 7, no. 1, pp. 1-19. https://doi.org/10.5321/wjs.v7.i1.1

Petridis, X, Beems, BP, Tomson, P, Scheven, B, Giepmans, B, Kuipers, J, van der Sluis, L & Harmsen, MC 2019, 'Effect of dentin matrix components on the mineralization of human mesenchymal stromal cells', Tissue Engineering Part A, vol. 25, no. 15-16, pp. 1104-1115. https://doi.org/10.1089/ten.TEA.2018.0192

Marrelli, M, Codispoti, B, Shelton, RM, Scheven, BA, Cooper, PR, Tatullo, M & Paduano, F 2018, 'Dental Pulp Stem Cell Mechanoresponsiveness: Effects of Mechanical Stimuli on Dental Pulp Stem Cell Behavior', Frontiers in Physiology, vol. 9, 1685. https://doi.org/10.3389/fphys.2018.01685

Gao, Q, Cooper, P, Walmsley, A & Scheven, B 2017, 'Role of PIEZO channels in ultrasound-stimulated dental stem cells', Journal of Endodontics. https://doi.org/10.1016/j.joen.2017.02.022

Mead, B, Logan, A, Berry, M, Leadbeater, W & Scheven, BA 2016, 'Dental pulp stem cells: a novel cell therapy for retinal and central nervous system repair', Stem Cells. https://doi.org/10.1002/stem.2398, https://doi.org/10.1002/stem.2398

Mead, B, Hill, LJ, Blanch, RJ, Ward, K, Logan, A, Berry, M, Leadbeater, W & Scheven, BA 2016, 'Mesenchymal stromal cell-mediated neuroprotection and functional preservation of retinal ganglion cells in a rodent model of glaucoma', Cytotherapy, vol. 18, no. 4, pp. 487-496. https://doi.org/10.1016/j.jcyt.2015.12.002

Gao, Q, Walmsley, A, Cooper, P & Scheven, B 2016, 'Ultrasound stimulation of different dental stem cell populations: role of mitogen-activated protein kinase signaling', Journal of Endodontics, vol. 42, no. 3, pp. 425-431. https://doi.org/10.1016/j.joen.2015.12.019

Davies, O, Cooper, P, Shelton, R, Smith, A & Scheven, B 2015, 'Isolation of adipose and bone marrow mesenchymal stem cells using CD29 and CD90 modifies their capacity for osteogenic and adipogenic differentiation', Journal of Tissue Engineering, vol. 6, pp. 1-10. https://doi.org/10.1177/2041731415592356

Chapter

Davies, O & Scheven, B 2016, Isolation and Cryopreservation of Stem Cells from Dental Tissues. in Dental Stem Cells: Regenerative Potential. Stem Cell Biology and Regenerative Medicine, Springer, Switzerland, pp. 57-71. https://doi.org/10.1007/978-3-319-33299-4_3

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