Professor Iain Styles

Professor Iain Styles

School of Computer Science
Professor of Computer Science

Contact details

Email
i.b.styles@bham.ac.uk
Twitter
@driainstyles
View my research portal
Address
School of Computer Science
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Iain Styles is a Professor of Computational Life Sciences in the School of Computer Science. His research interests are in the analysis of complex data from advanced imaging and analytical techniques to understand biological structures and processes, with particular interests in the analysis of single-molecule imaging experiments, automated analysis of mass spectrometry measurements, and image reconstruction methods for diffuse optical imaging. He uses a wide range of computational approaches to address these complex interdisciplinary problems, drawing on ideas from classical image processing, machine learning, computer vision, and topology.

He is a Fellow of the Alan Turing Institute and the University’s Turing University Lead, and is the founding Director of the Institute for Interdisciplinary Data Science and AI.

For more information, please see Iain's homepage.

Qualifications

  • PhD in Theoretical Condensed Matter Physics, University of Birmingham, 2003

  • MSci in Physics with Theoretical Physics, University of Birmingham, 1999

Biography

Following a short spell in the microelectronics industry, Iain Styles obtained an MSci with First Class Honours in Physics with Theoretical Physics from the University of Birmingham in 1999 and went on to complete a PhD in Theoretical Condensed Matter Physics in 2003. He then moved to the School of Computer Science in Birmingham for a postdoctoral position in the area of medical imaging, moving to a full academic position in 2005.

Teaching

Professor Styles teaches on a number of programs in the School of Computer Science, and on the postgraduate program in Physical Sciences for Healthcare.

Postgraduate supervision

Professor Styles has supervised more than twenty PhD students to successful completion. They have gone on to a range of careers, including prestigious postdoctoral positions at UCL, EMBL, Harvard, Cambridge, NPL and others. He is interested in supervising students working on computational techniques for the analysis of complex biological datasets.

Research

Professor Styles works in close collaboration with researchers from the chemical and biological sciences to develop novel methods for extracting information from large and complex datasets. Current research projects include:

  • Quantitative analysis of single molecule localisation microscopy datasets for the study of membrane proteins and receptors.
  • Information fusion in nanoparticle-enabled multimodal imaging
  • Automated sample classification from DNA optical maps
  • Developing novel latent representations for efficient inference in mass spectrometry
  • Interpretable machine learning techniques

Other activities

  • Member, EPSRC Peer Review College (since 2018)

Publications

Recent publications

Article

Jiménez‐rosés, M, Morgan, BA, Jimenez Sigstad, M, Tran, TDZ, Srivastava, R, Bunsuz, A, Borrega‐román, L, Hompluem, P, Cullum, SA, Harwood, CR, Koers, EJ, Sykes, DA, Styles, IB & Veprintsev, DB 2022, 'Combined docking and machine learning identifies key molecular determinants of ligand pharmacological activity on β2 adrenoceptor', Pharmacology Research and Perspectives, vol. 10, no. 5, e00994. https://doi.org/10.1002/prp2.994

Sisley, EK, Hale, OJ, Styles, IB & Cooper, HJ 2022, 'Native Ambient Mass Spectrometry Imaging of Ligand-Bound and Metal-Bound Proteins in Rat Brain', Journal of the American Chemical Society, vol. 144, no. 5, pp. 2120-2128. https://doi.org/10.1021/jacs.1c10032

Illes-Toth, E, Stubbs, CJ, Sisley, EK, Bellamy-Carter, J, Simmonds, AL, Mize, TH, Styles, IB, Goodwin, RJA & Cooper, HJ 2022, 'Quantitative Characterization of Three Carbonic Anhydrase Inhibitors by LESA Mass Spectrometry', Journal of the American Society for Mass Spectrometry, vol. 33, no. 7, pp. 1168-1175. https://doi.org/10.1021/jasms.2c00024

Pike, J, Simms, V, Smith, C, Morgan, N, Khan, A, Poulter, N, Styles, I & Thomas, S 2021, 'An adaptable analysis workflow for characterization of platelet spreading and morphology', Platelets, vol. 32, no. 1, pp. 54-58. https://doi.org/10.1080/09537104.2020.1748588

Jia, X, Thorley, A, Chen, W, Qiu, H, Shen, L, Styles, IB, Chang, HJ, Leonardis, A, De Marvao, A, O'Regan, DP, Rueckert, D & Duan, J 2021, 'Learning a Model-Driven Variational Network for Deformable Image Registration', IEEE Transactions on Medical Imaging. https://doi.org/10.1109/TMI.2021.3108881

Havlikova, J, May, R, Styles, I & Cooper, H 2021, 'Liquid extraction surface analysis mass spectrometry of ESKAPE pathogens', Journal of the American Society for Mass Spectrometry. https://doi.org/10.1021/jasms.0c00466

Melidis, L, Styles, I & Hannon, M 2021, 'Targeting structural features of viral genomes with a nano-sized supramolecular drug', Chemical Science, vol. 12, no. 20, pp. 7174-7184. https://doi.org/10.1039/d1sc00933h

Turova, P, Styles, I, Timashev, V, Kravets, K, Grechnikov, A, Lyskov, D, Samigullin, T, Podolskiy, I, Shpigun, O & Stavrianidi, A 2021, 'Unsupervised methods in LC-MS data treatment: application for potential chemotaxonomic markers search', Journal of Pharmaceutical and Biomedical Analysis, vol. 206, 114382. https://doi.org/10.1016/j.jpba.2021.114382

Griffiths, R, Hughes, J, Abbatiello, S, Belford, M, Styles, I & Cooper, H 2020, 'Comprehensive LESA mass spectrometry imaging of intact proteins by integration of cylindrical FAIMS', Analytical Chemistry, vol. 92, no. 4, pp. 2885-2890. https://doi.org/10.1021/acs.analchem.9b05124

Havlikova, J, May, RC, Styles, IB & Cooper, HJ 2020, 'Direct identification of bacterial and human proteins from infected wounds in living 3D skin models', Scientific Reports, vol. 10, no. 1, 11900. https://doi.org/10.1038/s41598-020-68233-6

Hale, OJ, Sisley, EK, Griffiths, RL, Styles, IB & Cooper, HJ 2020, 'Native LESA TWIMS-MSI: Spatial, Conformational, and Mass Analysis of Proteins and Protein Complexes', Journal of the American Society for Mass Spectrometry, vol. 31, no. 4, pp. 873-879. https://doi.org/10.1021/jasms.9b00122

Banbury, C, Styles, I, Eisenstein, N, Zanier, ER, Vegliante, G, Belli, A, Logan, A & Goldberg Oppenheimer, P 2020, 'Spectroscopic detection of traumatic brain injury severity and biochemistry from the retina', Biomedical Optics Express, vol. 11, no. 11, pp. 6249-6261. https://doi.org/10.1364/BOE.399473

Simmonds, A, Lopez-Clavijo, A, Winn, P, Russell, D, Styles, I & Cooper, H 2020, 'Structural analysis of 14-3-3-ζ-derived phosphopeptides using electron capture dissociation mass spectrometry, traveling wave ion mobility spectrometry, and molecular modeling', Journal of Physical Chemistry B, vol. 124, no. 3, pp. 461-469. https://doi.org/10.1021/acs.jpcb.9b08506

Pike, J, Khan, A, Pallini, C, Thomas, S, Mund, M, Ries, J, Poulter, N & Styles, I 2020, 'Topological data analysis quantifies biological nano-structure from single molecule localization microscopy', Bioinformatics, vol. 36, no. 5, pp. 1614–1621. https://doi.org/10.1093/bioinformatics/btz788

Wand, N, Smith, DA, Wilkinson, A, Rushton, A, Busby, SJW, Styles, I & Neely, RK 2019, 'DNA barcodes for rapid, whole genome, single-molecule analyses', Nucleic Acids Research, vol. 47, no. 12, gkz212, pp. e68. https://doi.org/10.1093/nar/gkz212

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