Mr Roger Holder

Primary Care Clinical Sciences
Medical Statistician

Contact details

Primary Care Clinical Sciences
School of Health and Population Sciences
College of Medical and Dental Sciences
University of Birmingham
Birmingham, B15 2TT

Roger Holder is Head of Statistics in the Primary Care Clinical Sciences unit of the School of Health and Population Sciences.

He has published over 200 research papers and two books in the general area of Applied and Medical Statistics.


  • BSc(Hons) Statistics UCL(1964)


Roger Holder is an Applied Statistician with over 40 years experience of working in the medical and applied statistics area. He has worked with medical colleagues in Clinical Chemistry, Cancer Trials, Cardiology, Psychiatry, Dentistry, Rheumatology, Paediatrics, Obstetrics and Gynaecology, Medicine, Immunology, Orthopaedics, Opthalmology as well as Primary Care and General Practice. In the past he has collaborated with research workers in industry and the Public sector and has acted as an expert witness.

Other activities

  • Statistician on the editorial board of Clinical Endocrinology


Marshall,A, Altman,DG, Holder, RL Comparison of imputation methods for handling missing covariate data when fitting a Cox proportional hazards model: a resampling study. BMC Med Red Methodol 2010, 10(1) 7

Hussain,S Mohammed, MA Haque, MS Holder,R Macleod, J and Hobbs,R.A simple method to ensure plausible multiple imputation for continuous multivariate data Communications in Statistics – Simulation and Computation, 39:9, 1779-1784 2010

McManus, RJ Mant, J Bray, EP Holder, R Jones, MI Greenfield, S Kaanbwa, B Banting, M Bryan, S Little, P Williams, B Hobbs, FDR Telemonitoring and self management in the control of hypertension (TASMINH”): a randomised controlled trial  The Lancet Vol 376 no 9736 p163-172 2010

Mant, J; Doust, J; Roalfe, A; Barton, P; Cowie, M R; Glasziou, P; Mant,D; McManus, R J; Holder, R; Deeks, J; Fletcher, K; Qume, M; Sohanpal, S; Sanders, S; Hobbs, F D R Systematic review and individual patient data meta-analysis of diagnosis of heart failure, with modelling of implications of different diagnostic strategies in primary care Health |Technol Assess 13 (32) 1-207, iii 2009

AL Pritchard, L Ratcliffe, E Sorour, S Haque, RL Holder, PW Bentham, CL Lendon (2009) Investigation of dopamine receptors in susceptibility to behavioural and psychological symptoms in Alzheimer's disease. International Journal of Geriatric Psychiatry 24 1020-1025

Pratt, G; Harding, S; Holder, R; Fegan, C; Pepper, C; Oscier, D; Gardiner, A; Bradwell, AR; Mead, G Abnormal serum free light chain ratios are associated with poor survival and
may reflect biological subgroups in patients with chronic lymphocytic leukaemia British Journal of Haematology 144 (2) 217-222 2009

Kostopoulou, O; Oudhoff, J; Nath, R; Delaney, BC; Munro, CW; Harries, C; Holder, R Predictors of diagnostic accuracy and safe management in difficult diagnostic problems in family medicine
Medical Decision Making 28 (5) 668-680 2008

Hussain, S; Mohamed, MA; Holder, R; Almasri, A; Shukur, G Performance Evaluation Based on the Robust Mahalanobis Distance and Multilevel Modeling Using Two New Strategies Communications in Statistics – simulation and computation 37 (10) 1966-1980 2008