Dr Julia Ast

Julia Ast

Institute of Metabolism and Systems Research
Postdoctoral Research Fellow

Contact details

+ 44 (0) 121 414 3768
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College of Medial and Dental Sciences
University of Birmingham
B15 2TT

Julia joined the Islet Biology Lab as a postdoctoral research fellow in 2016. Her research focuses on the development of novel tools to study G-protein coupled receptors, the glucagon-like peptide-1 receptor in particular, and ranges from genetics, molecular and cellular biology to chemical biology and photopharmacology.


  • Dr.rer.nat. (PhD equivalent), Philipps-University of Marburg (Germany), 2017
  • Master (M.Sc.) in Molecular and Cellular Biology, Philipps-University of Marburg (Germany), 2011
  • Bachelor (B.rer.nat.) in Genetics, University of Salzburg (Austria), 2009


Poc P*, Gutzeit VA*, Ast J*, Lee J*, Jones BJ, D’Este E, Mathes B, Lehmann M, Hodson DJ, Levitz J, Broichhagen J (2020). Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag subtrates. Chem Sci  *authors contributed equally

Ast J, Arvaniti A, Fine NHF, Nasteska D, Ashford FB, Stamataki Z, Koszegi Z, Bacon A, Jones BJ, Lucey MA, Sasaki S, Brierley DI, Hastoy B, Tomas A, D'Agostino G, Reimann F, Lynn FC, Reissaus CA, Linnemann AK, D'Este E, Calebiro D, Trapp S, Johnsson K, Podewin T, Broichhagen J, Hodson DJ (2020). Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics. Nat Commun. 11(1):467

Podewin T*, Ast J*, Broichhagen J*, Fine NHF, Nasteska D, Leippe P, Gailer M, Buenaventura T, Kanda N, Jones BJ, M'Kadmi C, Baneres JL, Marie J, Tomas A, Trauner D, Hoffmann-Röder A, Hodson DJ (2018). Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered PharmacologyACS Cent Sci.  4(2):166-179. *authors contributed equally

Podewin T, Broichhagen J, Frost C, Groneberg D, Ast J, Meyer-Berg H, Fine NHF, Friebe A, Zacharias M, Hodson DJ, Trauner D, Hoffmann-Röder A (2017). Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormoneChem Sci.  8(6):4644-4653. doi: 10.1039/c6sc05044a. Epub 2017 Apr 19.

Stehlik T, Sandrock B, Ast J, Freitag J (2014). Fungal peroxisomes as biosynthetic organellesCurr Opin Microbiol.  8-14.

Stiebler AC, Freitag J, Schink KO, Stehlik T, Tillmann BA, Ast J, Bölker M (2014). Ribosomal readthrough at a short UGA stop codon context triggers dual localization of metabolic enzymes in Fungi and animalsPLoS Genet. 10(10):e1004685. 

Freitag J, Ast J, Linne U, Stehlik T, Martorana D, Bölker M, Sandrock B (2014). Peroxisomes contribute to biosynthesis of extracellular glycolipids in fungiMol Microbiol.  93(1):24-36. 

Heimel K, Freitag J, Hampel M, Ast J, Bölker M, Kämper J (2013). Crosstalk between the unfolded protein response and pathways that regulate pathogenic development in Ustilago maydisPlant Cell. 25(10):4262-77. 

Ast J, Stiebler AC, Freitag J, Bölker M (2013). Dual targeting of peroxisomal proteinsFront Physiol. 4:297.

Freitag J, Ast J, Bölker M (2012). Cryptic peroxisomal targeting via alternative splicing and stop codon read-through in fungi. Nature. 485(7399):522-5. 

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