Mr Jak Grimes BSc MSc

Jak Grimes

Institute of Metabolism and Systems Research
PhD Student

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Institute of Metabolism and Systems Research
College of Medical and Dental Sciences
Centre of Membrane Proteins & Receptors (COMPARE)
University of Birmingham
B15 2TT

Jak Grimes is a PhD student in the lab of Davide Calebiro within the Institute of Metabolism and Systems Research (IMSR), funded by the Centre of Membrane Proteins and Receptors (COMPARE) at the University of Birmingham.

His research aims to uncover signalling mechanisms of G protein-coupled receptors (GPCRs) with the unprecedented spatiotemporal resolution offered by single-molecule microscopy methods. Using single-particle tracking, he studies the diffusion and dynamics of individual GPCRs, and their interacting partners, on the plasma membrane of living cells.

PhD thesis title

Multi-colour single-particle tracking of G-protein coupled receptors and β-arrestins


Fully funded by the Centre of Membrane Proteins & Receptors dual PhD studentship.



  • PhD Biophysics, University of Birmingham (2018-current)
  • MSc Immunology, King’s College London (2017-2018)
  • BSc (Hons) Biological Sciences, Aston University (2013-2017)


Calebiro D, Grimes J. G Protein-Coupled Receptor Pharmacology at the Single-Molecule Level. Annu Rev Pharmacol Toxicol. doi:10.1146/annurev-pharmtox-010919-023348 (2020)

Grimes J, Desai S, Charter NW, Lodge J, Santos RM, Isidro‐Llobet A, Mason AM, Wu Z, Wolfe LA, Anantharaman L, Green A, Bridges AM, Dalmas Wilk DA, and Brown AJ. MrgX2 is a promiscuous receptor for basic peptides causing mast cell pseudo-allergic and anaphylactoid reactions. Pharmacol Res Perspect. doi:10.1002/prp2.547 (2019)

Brown AJ, Grimes J, Desai S, Santos RM, Isidro-Llobet A, Mason A, Wu Z, Wolfe L, Dalmas Wilk DA, Green A, Charter N. The mast cell receptor MrgX2 and drug-induced anaphylaxis. J Pharmacol Toxicol Methods. doi:10.1016/j.vascn.2019.05.084 (2019)

Buenaventura T, Bitsi S, Laughlin WE, Burgoyne T, Lyu Z, Oqua A, Norman H, McGlone ER, Klymchenko AS, Correa IR, Walker A, Inoue A, Hanyaloglu A and Thomas A. Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells. PLoS Biol. doi:10.1371/journal.pbio.3000097 (2019)

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