Dr Konstantinos Manolopoulos MD DPhil

Dr Konstantinos Manolopoulos

Institute of Metabolism and Systems Research
Honorary Senior Clinical Lecturer

Contact details

Address
Institute of Metabolism and Systems Research
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Konstantinos Manolopoulos is an Honorary Senior Clinical Lecturer in Endocrinology with a research interest in human in vivo metabolic physiology. He is exploring the hormonal determinants of adipose tissue function, and is particularly interested in the factors causing adipocyte dysfunction in obesity. Furthermore, he investigates the cross-talk between adipose tissue and other organs such as gut, liver and muscle. He is responsible for the Human Integrative Physiology and Metabolism lab at the NIHR/Wellcome Trust Clinical Research Facility. His research is funded by the Society for Endocrinology and the Academy of Medical Sciences.

He is an Honorary Consultant in Endocrinology at the Queen Elizabeth Hospital Birmingham and his clinical interests range from PCOS to complex endocrine obesity.

Qualifications

  • DPhil Clinical Medicine 2011
  • MD 2005
  • MBChB 2004

Biography

Konstantinos Manolopoulos qualified in Medicine from the University of Dusseldorf, Germany in 2004. His core medical training was at the University Hospitals Dusseldorf and Bochum, Germany. He obtained an academic MD from the University of Bochum with a thesis on the effect of a collagen polymorphism on the severity of coronary artery disease in patients with type 2 diabetes. In 2007, he relocated to the UK and joined the University of Oxford as a Wellcome-Trust funded Clinical Research Fellow at the Oxford Laboratory for Integrative Physiology (Oxlip). Under the supervision and mentorship of Prof. Keith Frayn and Prof. Fredrik Karpe, he conducted in vivo research in human adipose tissue physiology. He obtained a DPhil in Clinical Medicine from the University of Oxford in 2011. He joined the University of Birmingham as a Clinical Lecturer at the Centre for Endocrinology, Diabetes and Metabolism (CEDAM) in 2011. In 2015 he became a HEFCE-funded Clinician Scientist in Endocrinology at the Institute of Metabolism and Systems Research.

Teaching

  • MBChB – Obesity
  • BMedSci – Adipocyte biology
  • BClinSci – In vivo metabolism assessment
  • MPharm – Biology of absorptive and postabsorptive state

Postgraduate supervision

Konstantinos Manolopoulos is interested in supervising medical students studying for intercalated degrees, as well as doctoral research students in the following areas:

  • Hormonal determinants of human adipose tissue function in vivo
  • Determinants of adipocyte dysfunction in obesity
  • The cross-talk between adipose tissue and peripheral organs, and the effect of exercise

If you are interested in studying any of these subject areas please contact Dr Manolopoulos on the contact details above.

Research

Konstantinos Manolopoulos’ research interest is in human metabolic in vivo physiology and pathophysiology, with a special interest in adipose tissue and obesity. He is interested in the hormonal determinants of adipose tissue function, and in particular what determines adipose tissue dysfunction leading to the deleterious health effects of obesity. Furthermore, he studies the cross-talk between adipose tissue and other organs, such as gut, liver and muscle.

He studies the function of human metabolic tissues under “near normal” conditions using a range of gold standard integrative physiology techniques such as the arterio-venous difference technique, stable isotope tracer methodology and xenon washout for selective measurements of fatty acid trafficking and adipose tissue blood flow. He also applies integrative physiology methods across muscle in vivo, using the arterio-venous difference technique and venous occlusion plethysmography for muscle blood flow measurements. These methods are complemented by in vitro cell culture-based work, helping to elucidate the molecular mechanisms behind tissue dysfunction.

Publications

Recent publications

Article

Wang, J, Shen, S, Price, M, Lu, J, Sumilo, D, Kuang, Y, Manolopoulos, K, Xia, H, Qiu, X, Cheng, KK & Nirantharakumar, K 2020, 'Glucose, insulin, and lipids in cord blood of neonates and their association with birthweight: differential metabolic risk of large-for-gestational-age and small-for-gestational-age babies', The Journal of pediatrics.

Kempegowda, P, Melson, E, Manolopoulos, K, Arlt, W & O'reilly, M 2020, 'Implicating androgen excess in propagating metabolic disease in polycystic ovary syndrome', Therapeutic Advances in Endocrinology and Metabolism. https://doi.org/10.1177/2042018820934319

Edinburgh, R, Bradley, H, Abdullah, N, Robinson, S, Chrzanowksi-Smith, O, Walhin, J-P, Joanisse, S, Manolopoulos, K, Philp, A, Hengist, A, Chabowski, A, Brodsky, F, Koumanov, F, Betts, J, Thompson, D, Wallis, G & Gonzalez, JT 2020, 'Lipid metabolism links nutrient-exercise timing to insulin sensitivity in men classified as overweight or obese', Journal of Clinical Endocrinology and Metabolism, vol. 105, no. 3, pp. 660–676. https://doi.org/10.1210/clinem/dgz104

Elhassan, YS, Kluckova, K, Fletcher, RS, Schmidt, MS, Garten, A, Doig, CL, Cartwright, DM, Oakey, L, Burley, CV, Jenkinson, N, Wilson, M, Lucas, SJE, Akerman, I, Seabright, A, Lai, Y, Tennant, DA, Nightingale, P, Wallis, GA, Manolopoulos, KN, Brenner, C, Philp, A & Lavery, GG 2019, 'Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces transcriptomic and anti-inflammatory signatures', Cell Reports, vol. 28, no. 7, pp. 1717-1728.e6. https://doi.org/10.1016/j.celrep.2019.07.043

O'reilly, M, Glisic, M, Kumarendran, B, Subramanian, A, Manolopoulos, K, Tahrani, A, Keerthy, D, Muka, T, Toulis, K, Hanif, W, Thomas, GN, Franco, OH, Arlt, W & Nirantharakumar, K 2019, 'Serum testosterone, sex hormone-binding globulin and sex-specific risk of incident type 2 diabetes in a retrospective primary care cohort', Clinical Endocrinology, vol. 90, no. 1, pp. 145-154. https://doi.org/10.1111/cen.13862

Kumarendran, B, O'Reilly, M, Manolopoulos, K, Toulis, K, Gokhale, K, Sitch, A, Wijeyaratne, CN, Coomarasamy, A, Arlt, W & Nirantharakumar, K 2018, 'Polycystic ovary syndrome, androgen excess, and the risk of nonalcoholic fatty liver disease in women: a longitudinal study based on a United Kingdom primary care database', PLoS Medicine, vol. 15, no. 3, e1002542. https://doi.org/10.1371/journal.pmed.1002542

Baig, S, Veeranna, V, Bolton, S, Edwards, N, Tomlinson, J, Manolopoulos, K, Moran, J, Steeds, R & Geberhiwot, T 2018, 'Treatment with PBI-4050 in patients with Alström syndrome: study protocol for a phase 2, single-Centre, single-arm, open-label trial', BMC Endocrine Disorders, vol. 18, 88. https://doi.org/10.1186/s12902-018-0315-6

O'Reilly, M, Kempegowda, P, Walsh, M, Taylor, A, Manolopoulos, K, Allwood, W, Semple, R, Hebenstreit, D, Dunn, W, Tomlinson, J & Arlt, W 2017, 'AKR1C3-mediated adipose androgen generation drives lipotoxicity in polycystic ovary syndrome', Endocrine Abstracts. https://doi.org/10.1530/endoabs.49.oc3.3

O'reilly, M, Kempegowda, P, Walsh, M, Taylor, A, Manolopoulos, K, Allwood, JW, Semple, RK, Hebenstreit, D, Dunn, W, Tomlinson, J & Arlt, W 2017, 'AKR1C3-mediated adipose androgen generation drives lipotoxicity in women with polycystic ovary syndrome', Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 9, pp. 3327–3339. https://doi.org/10.1210/jc.2017-00947

Manolopoulos, KN, O'Reilly, MW, Bujalska, IJ, Tomlinson, JW & Arlt, W 2017, 'Acute hypercortisolemia exerts depot-specific effects on abdominal and femoral adipose tissue function', Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 4, pp. 1091-1101. https://doi.org/10.1210/jc.2016-3600

Hornby, C, Botfield, H, O'reilly, M, Westgate, C, Mitchell, J, Mollan, S, Manolopoulos, K, Tomlinson, J & Sinclair, A 2017, 'Evaluating the fat distribution in Idiopathic Intracranial Hypertension using Dual energy X-ray absorptiometry scanning', Neuro-Ophthalmology. https://doi.org/10.1080/01658107.2017.1334218

Scotney, H, Symonds, ME, Law, J, Budge, H, Sharkey, D & Manolopoulos, K 2017, 'Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo', Metabolism, vol. 70, pp. 125-132. https://doi.org/10.1016/j.metabol.2017.01.024

Manolopoulos, K, Thornhill, H, Thomas, J, Arlt, W & Tomlinson, J 2015, 'Association between hypercortisolaemia and adipose tissue blood flow in vivo', The Lancet, vol. 385 Suppl 1, pp. S63. https://doi.org/10.1016/S0140-6736(15)60378-6

Woods, CP, Corrigan, M, Gathercole, L, Taylor, A, Hughes, B, Gaoatswe, G, Manolopoulos, K, Hogan, AE, O'Connell, J, Stewart, PM, Tomlinson, JW, O'Shea, D & Sherlock, M 2015, 'Tissue specific regulation of glucocorticoids in severe obesity and the response to significant weight loss following bariatric surgery (BARICORT)', The Journal of clinical endocrinology and metabolism, vol. 100, no. 4, pp. 1434-1444. https://doi.org/10.1210/jc.2014-4120

Pinnick, KE, Nicholson, G, Manolopoulos, KN, McQuaid, SE, Valet, P, Frayn, KN, Denton, N, Min, JL, Zondervan, KT, Fleckner, J, McCarthy, MI, Holmes, CC, Karpe, F & MolPAGE Consortium 2014, 'Distinct developmental profile of lower-body adipose tissue defines resistance against obesity-associated metabolic complications', Diabetes, vol. 63, no. 11, pp. 3785-97. https://doi.org/10.2337/db14-0385

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