Dr Daniela Nasteska MD, PhD

Dr Daniela Nasteska

Institute of Metabolism and Systems Research
Postdoctoral research fellow

Contact details

Address
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Daniela is a postdoctoral research fellow in Professor Hodson’s group 

Her research focuses on islet biology and more specifically, the role that beta-cellular heterogeneity has on islet function.

  • Top scoring basic science prize, Society for Endocrinology-BES conference, 2017
  • Publication data award from the Research development Fund, MDS-University of Birmingham, 2020

Qualifications

  • PhD in medicine, Kyoto University, Kyoto, Japan, 2014
  • MD, doctor of medicine, Ss. Cyril and Methodius University, Skopje, Macedonia, 2004
  • Member of the Doctor’s Chamber of Macedonia, 2004

Biography

Daniela started her professional career as a general practitioner in Macedonia, after earning her MD degree in 2004 from the Ss. Cyril and Methodius University in Skopje, Macedonia. She holds a PhD in medicine from the Department of Diabetes, Endocrinology and Nutrition at Kyoto University in Japan, which she earned in 2014. Her PhD research explored the role of the incretin hormone GIP and its link to obesity. She moved to the ULB-Université Libre De Bruxelles in Brussels, Belgium in 2015 and worked on understanding the mechanisms mediating ER stress-related beta cell death. In 2016, she joined Professor Hodson’s group at the IMSR where she works on elucidating the intricacies of islet biology.

Research

Daniela’s work in beta cell heterogeneity focuses on the existing degrees of beta cell maturity and how different less- or more-mature beta cells come together to ensure proper islet function and maintenance of normal blood sugar levels.

She also explores novel players involved in normal insulin secretion from the pancreatic islets, such as the enzyme PHD3, for which purpose she develops mouse models and traces the PHD3 role both in vivo and in vitro.

Research Groups and Centres

Other activities

  • MDS Postdoctoral/Early Researcher, Career Development and Training (PERCAT) representative for the IMSR
  • Member of the IMSR Community Action Team (CAT)

Publications

Nasteska, D, Fine, N, Ashford, F, Cuozzo, F, Viloria, K, Smith, G, Dahir, A, Dawson, PWJ, Lai, Y-C, Bastidas-Ponce, A, Bakhti, M, Rutter, G, Fiancette, R, Nano, R, Piemonti, L, Lickert, H, Zhou, Q, Akerman, I & Hodson, D 2020, 'PDX1LOW MAFALOW β-cells contribute to islet function and insulin release', Nature Communications.

Kemkem, Y, Nasteska, D, De Bray, A, Bargi-Souza, P, Peliciari-Garcia, R, Guillou, A, Mollard, P, Hodson, D & Schaeffer, M 2020, 'Maternal hypothyroidism in mice influences glucose metabolism in adult offspring', Diabetologia. https://doi.org/10.1007/s00125-020-05172-x

Nasteska D, Hodson DJ (2020). GPR119 Agonism Revisited: A Novel Target for Increasing β-Cell Mass? Endocrinology. Feb 1;161(2):bqz018  

Ast, J, Arvaniti, A, Fine, NHF, Nasteska, D, Ashford, FB, Stamataki, Z, Koszegi, Z, Bacon, A, Jones, BJ, Lucey, MA, Sasaki, S, Brierley, DI, Hastoy, B, Tomas, A, D’agostino, G, Reimann, F, Lynn, FC, Reissaus, CA, Linnemann, AK, D’este, E, Calebiro, D, Trapp, S, Johnsson, K, Podewin, T, Broichhagen, J & Hodson, DJ 2020, 'Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics', Nature Communications, vol. 11, no. 1, 467 . https://doi.org/10.1038/s41467-020-14309-w

Viloria, KM, Nasteska, D, Briant, LJB, Heising, S, Larner, D, Fine, N, Ashford, F, Da Silva Xavier, G, Jimenez-Gonzalez, M, Hasib, A, Cuozzo, F, Manning Fox, J, MacDonald, P, Akerman, I, Lavery, G, Flaxman, C, Morgan, N, Richardson, S, Hewison, M & Hodson, D 2020, 'Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion', Cell Reports, vol. 31, no. 11, 107761. https://doi.org/10.1016/j.celrep.2020.107761

Podewin, T, Ast, J, Broichhagen, J, Fine, N, Nasteska, D, Leippe, P, Gailer, M, Buenaventura, T, Kanda, N, Jones, B, N'Kadmi, C, Baneres, J-L, Marie, J, Tomas, A, Trauner, D, Hoffmann-Roder, A & Hodson, D 2018, 'Conditional and reversible activation of class A and B G protein-coupled receptors using tethered pharmacology', ACS Central Science, vol. 4, no. 2, pp. 166-179. https://doi.org/10.1021/acscentsci.7b00237

Nasteska D, Viloria K, Everett L, Hodson DJ (2019). Informing β-cell regeneration strategies using studies of heterogeneity. Mol Metab. Sep;27S(Suppl):S49-S59.

Hodson, D & Nasteska, D 2018, 'The role of beta cell heterogeneity in islet function and insulin release', Journal of Molecular Endocrinology, vol. 61, pp. R43-R60. https://doi.org/10.1530/JME-18-0011

Shibue K, Yamane S, Harada N, Hamasaki A, Suzuki K, Joo E, Iwasaki K, Nasteska D, Harada T, Hayashi Y, Adachi Y, Owada Y, Takayanagi R, Inagaki N (2015). Fatty acid-binding protein 5 regulates diet-induced obesity via GIP secretion from enteroendocrine K cells in response to fat ingestion. Am J Physiol Endocrinol Metab. Apr 1;308(7):E583-91. doi: 10.1152/ajpendo.00543.2014.

Iwasaki K, Harada N, Sasaki K, Yamane S, Iida K, Suzuki K, Hamasaki A, Nasteska D, Shibue K, Joo E, Harada T, Hashimoto T, Asakawa Y, Hirasawa A, Inagaki N (2015). Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion. Endocrinology. Mar;156(3):837-46.

Nasteska D, Harada N, Suzuki K, Yamane S, Hamasaki A, Joo E, Iwasaki K, Shibue K, Harada T, Inagaki N (2014). Chronic reduction of GIP secretion alleviates obesity and insulin resistance under high-fat diet conditions. Diabetes. Jul;63(7):2332-43.

Joo E, Muraoka A, Hamasaki A, Harada N, Yamane S, Kondo Y, Suzuki K, Nasteska D, Shibue K, Harada T, Iwasaki K, Tsuji H, Shide K, Inagaki N (2015). Enteral supplementation with glutamine, fiber, and oligosaccharide modulates incretin and glucagon-like peptide-2 secretion. J Diabetes Investig. May;6(3):302-8.

Kondo Y, Harada N, Sozu T, Hamasaki A, Yamane S, Muraoka A, Harada T, Shibue K, Nasteska D, Joo E, Sasaki K, Inagaki N (2013). A hospital-based cross-sectional study to develop an estimation formula for 2-h post-challenge plasma glucose for screeningimpaired glucose tolerance. Diabetes Res Clin Pract. Aug;101(2):218-25. 

Joo E, Yamane S, Hamasaki A, Harada N, Matsunaga T, Muraoka A, Suzuki K, Nasteska D, Fukushima T, Hayashi T, Tsuji H, Shide K, Tsuda K, Inagaki N (2013). Enteral supplement enriched with glutamine, fiber, and oligosaccharide attenuates experimental colitis in mice. Nutrition. Mar;29(3):549-55.

Suzuki K, Harada N, Yamane S, Nakamura Y, Sasaki K, Nasteska D, Joo E, Shibue K, Harada T, Hamasaki A, Toyoda K, Nagashima K, Inagaki N (2013). Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity. J Biol Chem. Jan 18;288(3):1929-38.

Yamane S, Harada N, Hamasaki A, Muraoka A, Joo E, Suzuki K, Nasteska D, Tanaka D, Ogura M, Harashima S, Inagaki N (2012). Effects of glucose and meal ingestion on incretin secretion in Japanese subjects with normal glucose tolerance. J Diabetes Investig. Feb 20;3(1):80-5.

View all publications in research portal