Dr Paul Walker PhD

Dr Paul Walker

Institute of Metabolism and Systems Research
Postdoctoral Research Fellow

Contact details

Address
Institute of Metabolism and Systems Research
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Paul is a Postdoctoral Research Fellow working in the group of Dr Dan Tennant.

His research investigates the metabolic adaptation of cancer cells by studying the metabolism of isotopically-enriched compounds as part of the Metabolic Tracer Analysis Core (MTAC). In particular, he is interested in the selective accumulation of heme precursors which are utilised in fluorescent-guided surgery for the removal of brain tumours.

Qualifications

  • PhD, Chemical Synthesis, 2019, University of Bristol
  • MChem, Chemistry, 2012, University of Oxford

Biography

Paul graduated with an MChem from the University of Oxford, completing his Master’s research in the lab of Professor Stuart Conway investigating enzyme inhibitor design and synthesis. He then moved to the University of Bristol to complete a PhD as part of the Bristol Chemical Synthesis CDT under the supervision of Professor Matt Crump and Professor Chris Willis. 

Paul’s research focussed on the mechanism and enzymology of polyketide biosynthetic pathways, which produce a wide-range of biologically-active secondary metabolites, including clinically-available antibiotics.

Publications

Thistlethwaite IRG, Bull FM, Cui C, Walker PD, Gao S-S, Wang L, Song Z, Masschelein J, Lavgine R, Crump MP, Race PR, Simpson TJ, Willis CL (2017) Elucidation of the Relative and Absolute Stereochemistry of the Kalimantacin/Batumin Antibiotics. Chem. Sci., 8, 6196.

 Walker PD, Williams C, Weir ANM, Wang L, Crosby J, Race PR, Simpson TJ, Willis CL, Crump MP (2019) Control of β‐Branching in Kalimantacin Biosynthesis: Application of 13C NMR to Polyketide Programming. Angew. Chem. Int. Ed., 131, 12576-12580.

 Walker PD, Rowe MT, Winter AJ, Weir ANM, Akter N, Wang L, Race PR, Williams C, Song Z, Simpson TJ, Willis CL, Crump MP (2020) A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis. ACS Chem. Biol. 15, 2, 494–503

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