Patents
Submitted:
- Horsnell WG & Clark HW. Protection against parasitic nematode infection by surfactant (SP-D) - RIS 13458. UK Patent Application No 1402909.4 University of Southampton AND University of Cape Town Filed 19th February 2014
Publications
(*: Equal contributions to publication. #: Corresponding authors):
Research papers:
1. Hoving C, Cutler A, Leeto M, Horsnell WG, Dewals B, Niewenhuizen N, Brombacher F. Interleukin-13-mediated colitis in the absence of IL-4Rα signalling. Gut. 2017 Feb 28. pii:. (IF: 14.921)
2. Thawer S*, Auret J*, Schnoeller C, Chetty A, Smith KA, Darby M, Roberts L, Mackay RM, Whitwell HJ, Timms JF, Madsen J, Selkirk ME, Brombacher F, Clark HW#, Horsnell WG#. Surfactant Protein-D is essential for immunity to helminth infection.PLoS Pathogens 2016. Feb 22. 12 (2): e1005461. (IF: 8.136)
3. Kirstein F, Nieuwenhuizen N, Jayakumar J, Horsnell WG, Brombacher F. Role of IL-4Ra+CD4+ T cells in chronic airway hyper-responsiveness. .Journal of Allergy and Clinical Immunology 2016 Dec 11. pii: S0091-6749(15)01670-X. (IF 12.047)
4. Darby M*, Schnoeller C*, Alykhan ViraA, Culley F, BobatS, LoganE, KirsteinF, WessJ, CunninghamAF, BrombacherF, SelkirkME#, HorsnellWG#. The M3 muscarinic receptor is required for optimal adaptive immunity to helminth and bacterial infection. PLoS Pathogens. 2015. Jan 28; 11(1): e1004636.(IF: 8.136)
5. Bobat S, Darby M, Mrdjen D, CookC, Logan E, Auret J, JonesE, SchnoellerC, Flores-LangaricaA, RossEA, ViraA, López-MacíasC, HendersonIR, AlexanderJ, BrombacherF, HorsnellWG#, CunninghamAF#. Natural and Vaccine-Mediated Immunity to Salmonella Typhimurium is Impaired by the Helminth Nippostrongylus brasiliensis. PLoS Neglected Tropical Diseases. 2014 Dec 4;8(12):e3341. (IF: 4.716)
6. Ndlovu H, Darby M, Froelich M, Horsnell WG, Lühder F, HünigT and Brombacher F. Inducible deletion of CD28 prior to secondary Nippostrongylus brasiliensis infection impairs worm expulsion and recall of protective memory CD4+ T cell responses. PLoS Pathogens. 2014. 6;10(2):e1003906. (IF: 8.136)
7. Thawer SG*, Horsnell WG*#, Darby M, Hoving JC, Benjamin Dewals, Cutler AJ and Brombacher F#. Lung-resident CD4+ T cells are sufficient for IL-4R dependent recall immunity to Nippostrongylus brasiliensis infection.Mucosal Immunology. 2014 Mar;7(2):239-48. (IF: 7)
8. HorsnellWG*, DarbyM*, Hoving JC, NieuwenhuizenN, McSorley HJ, Ndlovu H, BobatS, KimbergM, KirsteinF, CutlerAJ, DeWalsB, CunninghamAF, BrombacherF#. IL-4Rassociatedantigen processing by B cells promotes immunity in Nippostrongylus brasiliensis infection. PLoS Pathogens. 2013. 9(10):e1003662. (IF: 8.136)
9. NieuwenhuizenNN, MeterJ, Horsnell WGC, HovingJC, FickL, Sharp MF, Darby M, Parihar S, BrombacherF and LopataAL. "A cross-reactive monoclonal antibody to nematode haemoglobin enhances protective immune responses to Nippostrongylus brasiliensis" PLoS Neglected Tropical Diseases. 2013. 7(8):e2395. (IF: 4.716)
10. Schmidt S, Hoving JC, Horsnell WG, Mearns H, Cutler AJ, Brombacher TM, Brombacher F. Nippostrongylus-Induced Intestinal Hypercontractility Requires IL-4 Receptor Alpha-Responsiveness by T Cells in Mice.PLoS One. 2012;7(12):e52211. (IF: 3.73)
11. du Plessis N, Kleynhans L, Thiart L, van Helden PD, Brombacher F, Horsnell WG#, Walzl G#.Acute helminth infection enhances early macrophage mediated control of mycobacterial infection.Mucosal Immunology 2013 Sep;6(5):931-41. (IF 7)
12. Graham LM, Gupta V, Schafer G, Reid DM, Kimberg M, Dennehy KM, Horsnell WG, Guler R, Campanero-Rhodes MA, Palma AS, Feizi T, Kim SK, Sobieszczuk P, Willment JA, Brown GD#. The C-type lectin receptor clecsf8 (CLEC4D) is expressed by myeloid cells and triggers cellular activation through SYK kinase. Journal of Biological Chemistry. 2012 Jul 27;287(31):25964-74. (IF 4.651)
13. Nieuwenhuizen N*, Kirstein F*, Jayakumar J, Emedi B, Hurdayal R, Horsnell WG, Lopata AL, Brombacher F. Impairment of alternative activation of macrophages does not protect against allergic airway disease. Journal of Allergy and Clinical Immunology. 2012. 130(3):743-750.e8 (IF 12.047)
14. HorsnellWG*, Vira A*, KirsteinF, Mearns H, HovingJC, Cutler AJ, DewalsB, MyburghE, KimbergM, ArendseB, WhiteN, LopataAL, BurgerPE, BrombacherF. IL-4R responsive smooth muscle cells contribute to initiation of TH2 immunity and pulmonary pathology in Nippostrongylus brasiliensis infections. Mucosal Immunology. 2011. Jan;4(1):83-92. (IF: 7)
15. Martins Q, Horsnell WG, Titus W, Rautenbach T, Harris S. Diet determination of the Cape mountain leopard using GPS location clusters and scat analysis.Journal of Zoology.2011. Feb; 283 (2): 81-87.
16. Dewals B, Hoving JC, Horsnell WG, Brombacher F. Control of Schistosoma mansoni egg-induced inflammation by CD4+CD25−CD103+FoxP3− cells is IL-10 dependent. European Journal of Immunology. 2010. Oct;40(10):2837-47. (IF: 4.94)
17. Kirstein F, Horsnell WG, Nieuwenhuizen N, Ryffel B, Lopata AL, Brombacher F. Anisakis-induced airway hyperresponsiveness is mediated by IFN-gamma in the absence of IL-4R-responsiveness. Infection & Immunity. 2010. Sep;78(9):4077-86. (IF: 4.01)
18. Kirstein F, Horsnell WG, Kuperman DA, Huang X, Erle DJ, Lopata AL, Brombacher F. Expression of IL-4R on smooth muscle cells is not necessary for development of experimental allergic asthma. Journal of Allergy and Clinical Immunology. 2010. Aug;126(2):347-354. (IF: 12.047)
19. Marillier R*, Brombacher T*, Dewals B, Leeto M, Barkhuizen M, Govender D, Kellaway L, Horsnell WG, Brombacher F. IL-4Rα-responsive smooth muscle cells increase intestinal hypercontractility and contribute to resistance during acute Schistosomiasis. American Journal of Physiology - Gastrointestinal and Liver Physiology. 2010. Apr: 1.(IF:3.3)
20. Dewals B*, Hoving JC*, Leeto M, Marillier RG, Cutler AJ, Horsnell WG, Brombacher F. IL-4Rα responsiveness of non-CD4 T cells contributes to resistance in Schistosoma mansoni infection investigated in pan-T cell-specific IL-4Rα-deficient mice. American Journal of Pathology. 2009. Aug;175(2):706-16. (IF: 4.522)
21. Mearns H*, Horsnell WG*, Hoving JC, Dewals B, Cutler AJ, Kirstein F, Myburgh E, Arendse B, Brombacher F. IL-4 promoted T-helper 2 responses enhance Nippostrongylus brasiliensis induced pulmonary pathology. Infection & Immunity. Spotlight: Editorial Selected Article of Significant Interest. 2008. Dec;76(12):5535-42. (IF:4.01)
22. Marillier RG, Michels C, Smith EM, Fick LC, Leeto M, Dewals B, Horsnell WG, Brombacher F. IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections. BMC Immunology. 2008 Mar 28;9:11. (IF: 3.0)
23. Myburgh E, Horsnell WG, Cutler AJ, Arendse B, Kubo M, Brombacher F. Murine IL-4 is able to signal via chimeric human IL-4R/mouse gamma-chain receptor. Molecular Immunology. 2008 Mar; 45(5):1327-36. (IF: 2.91)
24. Parsons S*, Smith SG*, Martins Q, Horsnell WG, Gous TA, Streicher EM, Warren RM, van Helden PD, Gey van Pittius NC. Pulmonary infection due to the dassie bacillus (Mycobacterium tuberculosis complex sp.) in a free-living dassie (rock hyrax-Procavia capensis) from South Africa. Tuberculosis (Edinb). 2008 Jan; 88(1):80-83. (IF: 2.53)
25. Schwegmann A*, Guler R*, Cutler AJ, Arendse B, Horsnell WG, Flemming A, Kottmann AH, Ryan G, Hide W, Leitges M, Seoighe C, Brombacher F. Protein kinase C delta is essential for optimal macrophage-mediated phagosomal containment of Listeria monocytogenes. Proceedings of the National Academy of Sciences U S A. 2007 Oct 9; 104(41):16251-6. (IF: 9.77)
26. Horsnell WG, Cutler AJ, Hoving JC, Mearns H, Myburgh E, Arendse B, Finkelman FD, Owens GK, Erle D, Brombacher F. Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4R-deficient mice. PLoS Pathogens. 2007 Jan; 3(1):e1. (IF: 8.136)
27. Horsnell WG, Steel GJ, Morgan A. Analysis of NSF mutants reveals residues involved in SNAP binding and ATPase stimulation. Biochemistry. 2002 Apr 23; 41(16):5230-5. (IF: 3.22)
Books Edited and Book Chapters:
- Roberts CW and Horsnell WG. Chapter: Effects of sex and maternal immunity on protozoan and helminth infections. In: Sex and Gender Differences in Infection and Treatments for Infectious Diseases. 2015. Eds Klein SL and Roberts CW. Springer Press 2015
- Horsnell WG (Editor). How helminths influence immunity to infection (Springer Press. 2014. In Production).
- Horsnell WG, Brombacher F. Chapter: Alternatively activated macrophages in experimental parasitic infections. In: Advances in the Immunobiology of Parasitic Diseases. 2007. Eds: LI. Terrazas and S.G.Pandalai. Research Signpost
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