Dr Andy Philp

Dr Andy Philp

School of Sport, Exercise and Rehabilitation Sciences
Senior Lecturer in Integrative Physiology

Contact details

School of Sport, Exercise and Rehabilitation Sciences
University of Birmingham
B15 2TT

Dr Andy Philp is an integrative physiologist, interested in the molecular regulation of skeletal muscle adaptation. The main focus of his work is to examine how diet and exercise interact to regulate skeletal muscle mitochondrial function, adaptive growth and insulin sensitivity in the context of human athletic performance and in metabolic diseases such as sarcopaenia, obesity and type 2 diabetes.


BSc (Hons) - Sport and Exercise Sciences (University of Brighton)
PhD - Exercise Physiology (University of Brighton)


Dr Andrew Philp is a Senior lecturer in Integrative Physiology in the MRC-ARUK Centre for Musculoskeletal Ageing Research at the University of Birmingham (UoB). Andy is an established principal investigator with an international reputation of excellence in characterising the molecular regulation of skeletal muscle in response to activity and nutrition. This excellence is evidenced by the publication of over 40 peer-reviewed publications, in addition to 3 book chapters. Andy has published original research articles in high impact journals such as Cell, Journal of Clinical Investigation, Oncogene, Diabetes, Diabetelogia and the Journal of Biological Chemistry and reviewed manuscripts for ~20 peer reviewed journals, most recently invited to serve on the editorial board of PLoS One. Evidence of Andy’s development as a principal investigator is reflected in invitations to speak at national (The Physiological Society, BASES) and international (European College of Sport Sciences, American College of Sports Medicine (ACSM), Integrative Physiology of Exercise, Experimental Biology) conferences over the past 4 years.

Thequality of Andy’s research is reflected by New Investigator awards from the American Physiological Society and the RANK prize nutrition funds in addition to being the recipient of the 2012 University of California Davis award for excellence in post-doctoral research. In the past 3 years, since joining UoB, Andy has secured research funding in the form of RCUK PhD studentships (BBSRC, MRC), post-doctoral fellowships (Sir Henry Wellcome Post-doctoral fellowship, Kidney Research UK fellowship) and industry-related research grant funding. Most notably, Andy was the recent recipient of a New Investigator Award from the BBSRC in 2014 examining the role of the acetyltransferase GCN5 on skeletal muscle adaptation to endurance exercise and recently received funding from the UoB dynamic investment fund to establish a mitochondrial profiling centre, in which he will operate as the director. Currently the Philp research group consists of 4 PDRF, 4 PhD students, 1 research assistant and 3 Masters students (MRes & MSc).


Dr Philp leads the ‘Molecular Adaptation to training’ module, available to 3rd year undergraduate students studying the BSc Sport and Exercise Sciences degree.

In addition he teaches on a variety of cross-college post-graduate courses.

Postgraduate supervision

Dr Philp currently supervises four PhD students:

  • Mike McLeod – Start date 01/10/13, full time funded by the BBSRC (MIBTP).
  • Dan Craig – Start date 01/10/14, full time funded by the MRC.
  • Ben Stocks – Start date 01/10/14, full time funded by the BBSRC (MIBTP).
  • Nathan Hodson – Start date 01/10/15, full time funded by UoB (college studentship).


My current research focuses on how cellular energy status regulates skeletal muscle adaptations to exercise and inactivity. I am interested in the mechanisms by which substrate intermediates (fatty acids, glycogen) and by-products of contraction (NAD+, cAMP, Ca2+) regulate cellular metabolism, mitochondrial biogenesis and muscle growth. Recent work, in collaboration with Dr. Simon Schenk at the University of California San Diego (UCSD) (http://muscle.ucsd.edu/NSMRC/home.shtml) has utilized conditional knock-out mouse models to study the role of the NAD+-dependant protein deacetylase, sirtuin 1 (SIRT1), in the regulation of skeletal muscle insulin sensitivity in response to calorie restriction and mitochondrial biogenesis following endurance type exercise.

Current projects in the Philp laboratory are geared towards:

  1. Determining the role of protein lysine acetylation in metabolic regulation of skeletal muscle.
  2. Understanding the role of glycogen content in the adaptive responses to exercise.
  3. Investigating the molecular regulation of exercise induced mitochondrial protein synthesis.
  4. Identifying novel regulators of mitochondrial biogenesis in human skeletal muscle.

Post-doctoral researchers and Undergraduate/postgraduate students interested in studying these research areas are encouraged to contract Dr Philp via email (a.philp@bham.ac.uk) or phone (01214148872).

Other activities


American Physiological Society Endocrinology and Metabolism New Investigator Award (2014)

RANK Prize funds New Investigator Award (2013)

UC Davis Award for Excellence in Postdoctoral Research (2012)

American Physiological Society Research Recognition Award (2009)

Physiological Society Research Fellowship Award (2007)

Physiological Society/Diabetes UK Conference Travel Awards (2006)

Conference/Invited Talks:

Symposium organizer: aSIRTing Control on Cellular Metabolism: Role of the Sirtuins in Health and Disease, ACSM Annual Meeting, San Francisco (2012)

Diverse Metabolic Regulation by the Sirtuin Family of Protein Deacetylases, ACSM Annual Meeting, San Francisco (2012)

Metabolic Regulation of Exercise at and Above the Maximal Lactate Steady State (MLSS), ACSM Annual Meeting, San Francisco (2012)

Centre for Healthy Aging, University of Copenhagen, Denmark (2012)

National Skeletal Muscle Research Center, University of California, San Diego (2010)

International Biochemistry of Exercise Conference, Student Research Day, University of Guelph, Canada (2009)

GSK Sports Nutrition Symposium - European Congress of Sport Science, Oslo, Norway (2009)

PGC1α as a master regulator of mitochondrial metabolism – UK Sport and GB Cycling (2009)

Functional roles for the PGC1α related co-activator PRC in skeletal muscle – The Physiological Society Themed meeting (2009)

Molecular Nutrition Master Class – UK Sport and Team Great Britain (2009)


44. Craig, DM. Ashcroft, SP. Belew, MY. Stocks, B. Currell, K. Baar, K. Philp, A. (2015) Utilizing small nutrient compounds as enhoancers of exercise-induced mitochondrial biogenesis. Front Physiol. DOI: 10.3389/fphys.2015.00332

43. Philp, A. Schenk, S. Perez-Schindler, J. Hamilton, DL. Breen, L. LAverone, E. Jeromson, S. Phillips, SM. Baar, K. (2015) Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise. J Physiol. Sep;593(18):4275-84.

42. Perez-Schindler, J. and Philp, A. (2015) Regulation of skeletal muscle mitochondrial function by nuclear receptors: implications for health and disease. Clin Sci (Lond). Oct;129(7):589-99.

41. Brook, MS. Wilkinson, DJ. Phillips, BE. Perez-Schindler, J. Philp, A. Smith, K. Atherton, PJ. (2015) Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise. Acta Physiologica (Oxf) May 25. doi: 10.1111/apha.12532. [Epub ahead of print].

40. Philp A, Rowlands T, Perez-Schindler J, Schenk S (2014) Understanding the acetylome: Translating targeted proteomics into meaningful physiology. Am J Physiol Cell Physiol. ajpcell.00399.2013. [Epub ahead of print]

39. WhiteAT, PhilpA, FridolfssonHN,SchillingJM,Murphy AN, HamiltonDL, McCurdyCE, PatelHM, SchenkS, (2014) High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression. Am J Physiol Endocrinol Metab. ajpendo.00001.2014. [Epub ahead of print]

38. Perez-Schindler J, HamiltonDL, Moore DR, Baar K, Philp A (2014) Nutritional strategies to support concurrent training. Eur. J. Sports Sci. Aug 27: 1-12 [Epub ahead of print]

37. Hamilton DL.* Philp A,* MacKenzie M, Patton A, Towler M, Gallagher I, Bodine S, and Baar K. (2014) Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation. Am J Physiol Endocrinol Metab. 307(4):E365-73.

36. McGlory C, White A, Treins C, Drust B, Close GL, Maclaren DP, Campbell IT, Philp A, Schenk S, Morton JP, Hamilton DL. (2014) Application of the [γ-32P] ATP kinase assay to study anabolic signaling in human skeletal muscle. J. Appl. Physiol. 116(5):504-13

35. Philp, A. MacKenzie, M.G. Belew, M.Y. Towler, M.C. Corstorphine, A. Papalamprou, A. Hardie, D.G. and Baar, K. (2013) Glycogen content regulates peroxisome proliferator activated receptor-δ (PPAR-δ) activity in rat skeletal muscle. PLoS One. 17;8(10):e77200

34. Hamilton, D.L. and Philp, A. (2013) Can AMPK mediated suppression of mTORC1 explain the concurrent training effect? Cell. Mol. Exerc. Physiol. 2013, 2:1 doi: 10.7457/cmep.v2i1.e4

33. Hwee, D.T. Baehr, L.M. Philp, A. Baar, K. Bodine, S.C. (2013) Maintenance of muscle mass and load induced growth in muscle RING finger 1 null mice with age. Aging Cell. 3(1):92-101

32. White, A. McCurdy, C.E. Philp, A. Hamilton, D.L. Johnson, C. Schenk, S (2013) Skeletal muscle-specific overexpression of SIRT1 does not increase whole-body energy expenditure or insulin sensitivity in young mice. Diabetalogia. Jul;56(7):1629-37. doi: 10.1007/s00125-013-2912-2.

31. Philp, A and Schenk, S (2013) Unraveling the complexities of SIRT1-mediated mitochondrial regulation in skeletal muscle. Exerc. Sports Sci. Rev. Jul;41(3):174-81. doi: 10.1097/JES.0b013e3182956803.

30. Pérez-Schindler J, Philp A, Hernandez-Cascales J. (2013) Pathophysiological relevance of the cardiac β(2)-adrenergic receptor and its potential as a therapeutic target to improve cardiac function. Eur. J. Pharmacol. Jan 5;698(1-3):39-47. doi: 10.1016/j.ejphar.2012.11.001.

29. McCurdy, C.E. Schenk, S. Holliday, M.J. Philp, A. Houck, J.A. Patsouris, D. MacLean, P.S. Majka, S.M. Klemm, D.J. and Friedman, J.E. (2012) Attenuated PIK3R1 Expression Prevents Insulin Resistance and Adipose Tissue Macrophage Accumulation in Diet-Induced Obese Mice. Diabetes. Oct;61(10):2495-505. Epub 2012 Jun 14.

28. Philp, A. and Baar, K. (2012) Fine-tuning metabolism – how products of contraction regulate skeletal muscle adaptation. Am J Physiol Endocrinol Metab. Jun 1;302(11):E1313-4. Epub 2012 Mar 20.

27. Churchward-Venne, T.A. Burd, N.A. Mitchell, C.J. West, D.W.D. Philp, A. Marcotte, G.R. Baker, S.K. Baar, K and Phillips, S.M. (2012) Supplementation of a sub-optimal protein dose with leucine or essential amino acids: Effects on myofibrillar protein synthesis at rest and following resistance exercise in men. J. Physiol. Jun 1;590(Pt 11):2751-65. Epub 2012 Mar 25.

26. Schenk, S. and Philp, A. (2012) SIRT1-Independent mitochondrial biogenesis – The master regulator fails the in vivo test. J Appl Physiol. Mar; 112(5):929-30.

25. Philp, A. Hargreaves, M. and Baar, K. (2012) More than a store: Regulatory roles for glycogen in skeletal muscle adaptation to exercise. Am J Physiol Endocrinol Metab. Jun 1;302(11):E1343-51. Epub 2012 Mar 6.

24. Park, S-J. Ahmed, F. Philp, A. Baar, K. Williams, T. Luo, H. Ke, H. Rehmann, H. Taussig, R. Kim, M.K. Beaven, M.A. Manganiello, V. Chung, J.H. (2012). Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell. Feb 3;148(3):421-33.

23. Schenk, S. McCurdy, C.E. Philp, A. Chen, MZ. Holliday, MJ. Bandyopadhyay, GK. Osborn, O. Baar, K. Olefsky, JM.  (2011). SIRT1 mediates enhanced skeletal muscle insulin sensitivity in calorie-restricted mice.  J Clin Invest. Nov;121(11):4281-8.

22. Philp, A. (2011)Should Willy Wonka have been a sports nutritionist? J. Physiol. Oct 1;589(Pt 19):4643.

21. Philp, A. Belew, M.Y. Evans, A. Pham, D. Sivia, I. Chen, A. Schenk, S. Baar, K. (2011) The PGC-1α related co-activator (PRC) promotes mitochondrial and myogenic adaptations in C2C12 myotubes. Am. J. Physiol. Regul. Integr. Comp. Physiol. Oct;301(4):R864-72.

20. Philp, A. Chen, A. Lan, D. Meyer, G.A. Murphy, A.N. Knapp, A.E. Olfert, I.M. McCurdy, C.E. Marcotte, G.R. Hogan, M.C. Baar, K. Schenk, S. (2011) Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator activated receptor-γ coactivator-1α (PGC-1α) deacetylation following endurance exercise. J. Biol. Chem. Sep 2;286(35):30561-70.

19. Breen, L. Philp, A. Witard, O.C. Jackman, S.R. Selby, A. Smith, K. Baar, K. Tipton, K.D. (2011) The influence of carbohydrate-protein co-ingestion following endurance exercise on myofibrillar and mitochondrial protein synthesis. J. Physiol. Aug 15;589(Pt 16):4011-25. Epub 2011 Jul 11.

18. Breen, L. Philp, A. Shaw, C.S. Jeukendrup, A.E. Baar, K. Tipton, K.D. (2011) Beneficial effects of resistance exercise on glycemic control are not further improved by protein ingestion. PLoS One. 6(6): e20613.

17. Perez-Schindler, J. Philp, A. Baar, K. Hernandez-Cascales, J. (2011) Regulation of contractility and metabolic signalling by the B2-adrenergic receptor in rat ventricular muscle. Life Sci. 88(19-20): 892-7.

16. Preston, R.S. Philp, A. Cleasens, T. Dunlop, E.A. Gijezen, L. Harper, K.T. Brinkhuizen, T. Davies, D.M. Land, S.S. Baar, K. van Steensel, M. Tee, A.R. (2010) Absence of the Birt-Hodd-17. Dube gene product is associated with increased hypoxia inducible factor transcriptional activity and a loss of metabolic flexibility. Oncogene. 30(10): 1159-73.

15. Deldicque, L. Cani, P.D. Philp, A. Raymackers, J.M. Meakin, P.J. Ashford, M.L. Delzenne, N.M. Francaux, M. Baar, K. (2010) The unfolded protein response is activated in skeletal muscle by high fat feeding: potential role in the down-regulation of protein synthesis. Am. J. Physiol. Endocrinol. Metab. 299(5): E695-705.

14. Philp, A. Perez-Schindler, J. Green, C. Hamilton, D.L. Baar, K. (2010) Pyruvate suppresses PGC1a expression and substrate utilisation despite increased respiratory chain content in C2C12 myotubes. Am. J. Physiol. Cell. Physiol. 299(2): C240-50. 

13. Hulston, C.J. Venables, M.C. Mann, C.H. Martin, C. Philp, A. Baar, K. Jeukendrup, A.E. (2010) Training with low muscle glycogen enhances adaptations in fat metabolism in well-trained cyclists.  Med. Sci. Sports. Exerc. 42(11): 2046-55.

12. Donnelly, K. Khodabukus, A. Philp, A. Deldicque, L. Dennis, R.G. Baar, K. (2010) A novel bioreactor for stimulating skeletal muscle in vitro. Tissue Eng. Part C Methods. 16(4):711-8.

11. Philp, A. Hamilton, D.L. Baar, K. (2010) Signals mediating skeletal muscle remodeling by resistance exercise: PI3-kinase independent activation of mTORC1. J. Appl. Physiol. 110(2): 561-8.

10. Hamilton, D.L. Philp, A. MacKenzie, M.G. Baar, K. (2010) A limited role for PI(3,4,5)P3 regulation in controlling skeletal muscle mass in response to resistance exercise. PLoS One: 5(7): e11624.

9. Baar, K. Hamilton, D.L. Philp, A. (2010) Irrelevant growth factor-1. J. Appl. Physiol. 108(6):1827.

8. Hamilton, D.L. Philp, A. MacKenzie, M.G. Baar, K. (2010) Prolonged activation of S6K1 does not suppress IRS or PI-3 kinase signaling during muscle cell differentiation. BMC Cell Biol. May 27: 11-37.

7. Dennis, R.G. Smith, B. Philp, A. Donnelly, K. Baar, K. (2009) Bioreactors for guiding muscle tissue growth and development. Adv. Biochem. Engin. Biotechnol. 112: 39-79

6. Etheridge, T., Philp, A. and Watt, P.W. (2008) A single protein meal increases recovery of muscle function following an acute eccentric exercise bout. Appl. Physiol. Nutr. Metab. (33) (3): 483-488.

5. Philp, A. and Baar, K. (2008) Optimizing training adaptation by manipulating glycogen. Agro. Food Ind. High Tech. (19) (2): 18-24.

4. Philp, A., Macdonald, A.L., Carter, H., Watt, P.W. and Pringle, J.S. (2008) Maximal Lactate Steady State as a training stimulus. Int. J. Sports. Med. 29(6):475-479.

3. Macdonald, A.L., Philp, A., Harrison, M., Bone, A.J., and Watt, P.W. (2006) Monitoring exercise-induced changes in glycaemic control in type 2 diabetes. Med. Sci. Sports. Exerc. 38 (2): 201-207.

2. Castle, P.C., Macdonald, A.L., Philp, A., Webborn, A., Watt, P.W., and Maxwell, N.S. (2006) Pre-cooling leg muscle improves intermittent sprint exercise performance in hot, humid conditions. J. Appl. Physiol. 100: 1377-1384.

1. Philp, A., Macdonald, A.L., and Watt, P.W. (2005) Lactate – a signal coordinating cell and systemic function. J. Exp. Biol. 208(Pt 24): 4561-4575.