The Humphreys Annual Lecture 2017: Ronald G. Tompkins, Harvard Medical School
- Leonard Deacon Lecture Theatre Medical School
- Medical and Dental Sciences
Improving Trauma and Burn Patient Care: The clinical relevance of omics based research
By developing the clinical infrastructure to study critically ill trauma populations, as well as the technological and bioinformatics skills to isolate leukocyte populations and probe the transcriptome and proteome as they respond to severe injury, the “Inflammation and the Host Response to Injury" Glue Grant Program has made unprecedented advances in the understanding of the human inflammatory response.
The Glue Grant has generated the largest human dataset to date, and likely for the foreseeable future, on the human genomic and proteomic responses to injury in total leukocytes, enriched leukocyte populations (neutrophils, monocytes, and T cells), and from human skeletal muscle, fat, and skin tissue, thereby providing a unique opportunity for data mining towards improved understanding of the mechanism(s) of inflammation and injury as well as better prediction of patient recovery trajectories.
Such an improved understanding should lead to genomic and proteomic markers that predict ultimate patient outcomes both good and bad, and should suggest new targets for further basic and clinical research, as well as fruitful targets for pharmacological and immuno-modulatory interventions. These findings have broad application to virtually all surgical patients as the innate immune system is central to the field of transplantation and for the pathogenesis of post-operative sepsis and infections in all surgical populations.