Research In 'Birmingham Tissue Analytics' Birmingham Tissue AnalyticsAbout usResearchServicesContact us Back to 'Facilities' Immunohistochemistry Nayar S, Pontarini E, Campos J, Berardicurti O, Smith CG, Asam S, Gardner DH, Colafrancesco S, Lucchesi D, Coleby R, Chung MM, Iannizzotto V, Hunter K, Bowman SJ, Carlesso G, Herbst R, McGettrick HM, Browning J, Buckley CD, Fisher BA, Bombardieri M, Barone F. Immunofibroblasts regulate LTα3 expression in tertiary lymphoid structures in a pathway dependent on ICOS/ICOSL interaction.Commun Biol. 2022 May 4;5(1):413. doi: 10.1038/s42003-022-03344-6. PMID: 35508704; PMCID: PMC9068764. Jeffery HC, Hunter S, Humphreys EH, Bhogal R, Wawman RE, Birtwistle J, Atif M, Bagnal CJ, Rodriguez Blanco G, Richardson N, Warner S, Dunn WB, Afford SC, Adams DH, Oo YH. Bidirectional Cross-Talk between Biliary Epithelium and Th17 Cells Promotes Local Th17 Expansion and Bile Duct Proliferation in Biliary Liver Diseases. J Immunol. 2019 Sep 1;203(5):1151-1159. doi: 10.4049/jimmunol.1800455. Epub 2019 Aug 7. PMID: 31391236; PMCID: PMC6697739. Brooks JM, Menezes AN, Ibrahim M, Archer L, Lal N, Bagnall CJ, von Zeidler SV, Valentine HR, Spruce RJ, Batis N, Bryant JL, Hartley M, Kaul B, Ryan GB, Bao R, Khattri A, Lee SP, Ogbureke KUE, Middleton G, Tennant DA, Beggs AD, Deeks J, West CML, Cazier JB, Willcox BE, Seiwert TY, Mehanna H. Development and Validation of a Combined Hypoxia and Immune Prognostic Classifier for Head and Neck Cancer.Clin Cancer Res. 2019 Sep 1;25(17):5315-5328. doi: 10.1158/1078-0432.CCR-18-3314. Epub 2019 Jun 10. PMID: 31182433. Pugh M, Akarka AU, Hunter K, Dojcinov S, Marafioti T. Multiplex immunohistochemistry in lymphoma pathology: a research tool for study of the immune microenvironment.2020 Diagnostic Histopathology, 26 (9): 407-420, ISSN 1756-2317. Nayar S, Campos J, Smith CG, Iannizzotto V, Gardner DH, Colafrancesco S, Pipi E, Kollert F, Hunter KJ, Brewer C, Buckley CD, Bowman SJ, Priori R, Valesini G, Juarez M, Fahy WA, Fisher BA, Payne A, Allen RA, Barone F. Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren's syndrome.Ann Rheum Dis. 2019 Feb;78(2):249-260. doi: 10.1136/annrheumdis-2017-212619. Epub 2018 Nov 24. PMID: 30472652; PMCID: PMC6352416. nCounter Clayton SA, Daley KK, MacDonald L, Fernandez-Vizarra E, Bottegoni G, O'Neil JD, Major T, Griffin D, Zhuang Q, Adewoye AB, Woolcock K, Jones SW, Goodyear C, Elmesmari A, Filer A, Tennant DA, Alivernini S, Buckley CD, Pitceathly RDS, Kurowska-Stolarska M, Clark AR. Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene. Sci Adv. 2021 Dec 10;7(50):eabl5182. doi: 10.1126/sciadv.abl5182. Epub 2021 Dec 8. PMID: 34878835; PMCID: PMC8654286. Clinical trials Juarez M, Diaz N, Johnston GI, Nayar S, Payne A, Helmer E, Cain D, Williams P, Devauchelle-Pensec V, Fisher BA, Giacomelli R, Gottenberg JE, Guggino G, Kvarnström M, Mariette X, Ng WF, Rosas J, Sánchez Bursón J, Triolo G, Barone F, Bowman SJ. A phase 2 randomized, double-blind, placebo-controlled, proof-of-concept study of oral seletalisib in primary Sjögren's syndrome. Rheumatology (Oxford). 2021 Mar 2;60(3):1364-1375. doi: 10.1093/rheumatology/keaa410. PMID: 32949140.