Dr Andrew Bell PhD BSc

Dr Andrew Bell

Institute of Cancer and Genomic Sciences
Research Fellow

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Institute of Cancer and Genomic Sciences

Dr Andrew Bell is a Research Fellow in the Institute of Cancer and Genomic Sciences. His research aims to understand how Epstein-Barr virus, a common herpesvirus with oncogenic properties, contributes to the development of several human malignancies. This work is funded by Cancer Research UK and involves collaborations with other members of the Centre for Human Virology

Qualifications

  • PhD in Biochemistry, University of Birmingham 1990
  • BSc (Hons) in Biochemistry, 1987

Teaching

  • BSc Biomedical Science
    Y2 Advanced Molecular and Experimental Genetics
    Y3 Viruses: Threats and Defences
  • MBChB Cancer: Causes to Cures
  • B Med Sci Clinical Sciences (Intercalated)
  • MSc/PGDip Clinical Oncology
    Introduction
    Molecular Pathology of Cancer
  • MSc Genomic Medicine

Postgraduate supervision

Dr Bell has extensive experience in supervising and training PhD students in the area of EBV infection and the pathogenesis of EBV-associated lymphomas

Research

RESEARCH THEME: Viral oncology

Epstein-Barr Virus

Dr Bell is a member of a research team interested in the biology of EBV and its role in lymphomagenesis.

Epstein-Barr virus (EBV) is a member of the herpesvirus family and is widespread in all human populations. Following primary infection, the virus establishes lifelong persistence within a type of blood cell called a B lymphocyte. In the vast majority of cases, EBV infection is generally harmless. However in rare circumstances virus infection is linked to the development of several human cancers of B cell origin; these include post transplant lymphoproliferative disease (PTLD), Burkitt lymphoma (BL) and Hodgkin lymphoma (HL).  A clue to EBV’s role in lymphomagenesis comes from the observation that EBV can transform normal B lymphocytes in vitro into continuously growing lymphoblastoid cells (LCL). 

Dr Bell’s work addresses the following areas:

  • EBV persistence in normal healthy individuals
  • The effects of EBV infection on cellular phenotype
  • Virus gene expression in different cell types
  • The role of EBV in lymphomagenesis
Dr Bell has strong links with other EBV research groups in the Institute of Cancer and Genomics and the Centre for Human Virology, together with a number of national and international collaborations

Other activities

  • EBV Association Board member (2012-)
  • Member of Microbiology Society

Publications

Burns DM, Tierney R, Shannon-Lowe C, Croudace J, Inman C, Abbotts B, Nagra S, Fox CP, Chaganti S, Craddock C, Moss P, Rickinson AB, Rowe M and Bell AI (2015). Memory B cell reconstitution following allogeneic haematopoietic stem cell transplantation is an EBV-associated transformation event.  Blood Oct 8. pii: blood-2015-08-665000. [Epub ahead of print]

Jayasooriya S, de Silva TI, Njie-Jobe J, Sanyang C, Leese AM, Bell AI, McAulay KA, Yanchun P, Long HM, Dong T, Whittle HC, Rickinson AB, Rowland-Jones, SL, Hislop AD and Flanagan KL (2015).Early virological and immunological events in asymptomatic Epstein-Barr virus infection in African children. PLoS Pathog 11(3):e1004746.

Tierney RJ, Nagra J, Rowe M, Bell AI and Rickinson AB (2015). The Epstein-Barr virus BamHI C promoter is not essential for B cell immortalisation in vitro but greatly enhances B cell growth transformation. J Virol 89: 2483-2493.

Tierney RJ, Shannon-Lowe C, Fitzsimmons L, Bell AI and Rowe M. Unexpected patterns of Epstein-Barr virus transcription revealed by a high throughput PCR array for absolute quantification of viral mRNA. (2015) Virology 474: 117-130.

Kelly GL, Stylianou J, Rasaiyaah J, Wei W, Thomas W, Croom-Carter D, Kohler C, Spang R, Woodman C, Kellam P, Rickinson AB, Bell AI. (2013). Different patterns of Epstein-Barr virus latency in endemic Burkitt lymphoma (BL) lead to distinct variants within the BL-associated gene expression signature. J Virol 87:2882-94.

Heath, E, Begue-Pastor, N, Chaganti,S, Croom-Carter, D, Shannon-Lowe, C, Kube, D, Feederle, R, Delecluse, HJ, Rickinson, ABand Bell, AI (2012). Epstein-Barr virus infection of naïve B cells in vitro frequently selects clones with mutated immunoglobulin genotypes: implications for virus biology. PLoS Pathog. 8(5): e1002697. doi:10.1371/journal.ppat.1002697

Jayasooriya S, Hislop A, Peng Y, Croom-Carter D, Jankey Y, Bell, A, Dong, T, Rowland-Jones, S, Rickinson, A, Walther, M and Whittle, H (2012). Revisiting the effect of acute P. falciparum malaria on Epstein-Barr virus: Host balance in the setting of reduced malaria endemicity. PLoS ONE 7(2): e31142. doi:10.1371/journal.pone.0031142

Amoroso, R, Fitzsimmons, L, Thomas, WA, Kelly, GL, Rowe, M and Bell, AI (2011). Quantitative studies of Epstein-Barr virus-encoded microRNAs provide novel insights into their regulation. J. Virol. 85: 996-1010.