Dr Neil Morgan

 

Lecturer in Cardiovascular Genetics

Cardiovascular and Respiratory Sciences

Contact details

Telephone +44 (0)121 415 8678

Email n.v.morgan@bham.ac.uk

School of Clinical and Experimental Medicine
College of Medical and Dental Sciences
Institute of Biomedical Research
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

About

Neil Morgan is a Lecturer in Cardiovascular Genetics within the School of Clinical and Experimental Medicine.

He has published over 50 research papers in scientific journals in the field of human genetics. His research has primarily involved the identification of novel genes for autosomal recessive inherited diseases.

Qualifications

  • PhD in Molecular Genetics 2005
  • BSc (Hons) Applied Biochemistry 1994

Biography

Neil Morgan qualified with a BSc (Hons) in Applied Biochemistry from Liverpool John Moores University in 1994. His first post was as Research Assistant at Guy’s Hospital until 2000 followed by a brief spell as a Research Associate at Leicester University. He joined the Medical and Molecular Genetics group at the University of Birmingham where he went onto study for a PhD in Molecular Genetics. He has recently been appointed as a lecturer in the Centre for Cardiovascular Sciences.

Teaching

  • BMedSci
  • MRes (Hormones and Genes)

Research

His current research is focussing on the molecular genetics of patients with platelet bleeding disorders and low platelet counts (thrombocytopaenia). The identification of novel gene defects would provide clues to genes and proteins involved in normal platelet physiology and ultimately lead to devising new treatment strategies to minimise the risk of bleeding in such patients. The ultimate goal of this project is to extrapolate these findings to devising new treatments and treatment strategies that would minimize risk of bleeding in selected cohorts of patients.

His past research has primarily involved identification of the novel genes for autosomal recessive inherited diseases. He has been extremely successful in his pursuit and key findings include:

  • TRAC mutations causing a novel immunodeficiency disorder
  • SLC29A3 mutations causing familial Faisalabad histiocytosis/Rosai-Dorfman disease
  • BLOC1S3 mutationscausing a novel form of Hermansky Pudlak disorder (HPS8)
  • CHRNG, RAPSN and DOK7 mutations causing multiple pterygia syndrome/foetal akinesia deformation sequence
  • PLA2G6 mutations causing a spectrum of childhood onset neurodegenerative disorders associated with brain iron accumulation

Publications

Nieminen P, Morgan NV, Fenwick AL, Parmanen S, Veistinen L, Mikkola ML, van der Spek PJ, Giraud A, Judd L, Arte S, Brueton LA, Wall SA, Mathijssen IMJ, Maher ER, Wilkie AOM, Kreiborg S, Thesleff I (2011) Inactivation of IL11 Signaling Causes Craniosynostosis, Delayed Tooth Eruption and Supernumerary Teeth. Am J Hum Genet July 7. [Epub ahead of print]

MorganNV, GoddardS, CardnoTS, McDonald D, RahmanF, BargeD, CiupekA, Straatman-IwanowskaA,PashaS, GuckianM, AndersonG, HuissoonA, CantA, TateWP, HambletonS, MaherER (2011) Mutation in the TCRa subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRab+ T cells. J Clin Invest 121(2):695-702

Bolze A, Byun M, McDonald D, Morgan NV, Abhyankar A, Premkumar L, Puel A, Bacon CM, Rieux-Laucat F, Pang K, Britland A, Abel L, Cant A, Maher ER, Riedl SJ, Hambleton S, Casanova JL (2010) Whole-exome-sequencing-based discovery of human FADD deficiency. Am J Hum Genet 87(6):873-81

Kurian MA, Meyer E, Vassallo G, Morgan NV, Prakash N, Pasha S, Hai NA, Shuib S, Rahman F, Wassmer E, Cross JH, O'Callaghan FJ, Osborne JP, Scheffer IE, Gissen P, Maher ER. (2010) Phospholipase C beta 1 deficiency is associated with early-onset epileptic encephalopathy. Brain 133(10):2964-70

Meyer E, Ricketts C, Morgan NV, Morris MR, Pasha S, Tee LJ, Rahman F, Bazin A , Bessières B, Déchelotte P , Yacoubi MT, Al-Adnani M, Marton T, Tannahill D, Trembath RC, Fallet-Bianco C , Cox P , Williams D, Maher ER (2010). Mutations in FLVCR2 Are Associated with Proliferative Vasculopathy and Hydranencephaly-Hydrocephaly Syndrome (Fowler Syndrome). Am J Hum Genet 86:471-8

Hartley JL, Zachos NC, Dawood B, Donowitz M, Forman J, Pollitt RJ, Morgan NV, Tee L, Gissen P, Kahr WH, Knisely AS, Watson S, Chitayat D, Booth IW, Protheroe S, Murphy S, de Vries E, Kelly DA, Maher ER (2010). Mutations in TTC37 Cause Trichohepatoenteric Syndrome (Phenotypic Diarrhoea in Infancy). Gastroenterology 138 (7):2388-98

Morgan NV, Morris MR, Cangul H, Gleeson D, Straatman-Iwanowska A, Davies N, Keenan S, Pasha S, Rahman F, Gentle D,Vreeswijk MPG, Devilee P, Knowles MA, Ceylaner S, Trembath RC, Dalence C, Kismet E, Koseoglu V, Rossbach H-C, Gissen P, Tannanhill D, Maher ER (2010). Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial Histiocytosis syndrome (Faisalabad histiocytosis) and Familial Rosai-Dorfman disease. PLoS Genetics 6(2):e1000833

Kurian MA, Zhen J, Cheng SY, Li Y, Mordekar SR, Jardine P, Morgan NV, Meyer E, Tee L, Pasha S, Wassmer E, Heales SJ, Gissen P, Reith ME, Maher ER (2009). Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia. Journal of Clinical Investigation 119:1595-603

Back to top