Dr Chris Weston BSc PhD

Dr Chris Weston

Institute of Immunology and Immunotherapy
Senior Research Fellow

Contact details

Telephone
+44 (0)121 415 8784
Fax
+44 (0)121 415 8701
Email
c.j.weston@bham.ac.uk
Address
NIHR Biomedical Research Unit and Centre for Liver Research
5th Floor Institute for Biomedical Research
The Medical School
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Chris Weston is a post-doctoral research fellow based in the Centre for Liver Research who has received grant funding from the MRC and the Wellcome Trust.

His research focus is the regulation of immune mediated injury and fibrosis in the human liver, with a view to establish the role that amine oxidases such as vascular adhesion protein-1 (VAP-1) and the lysyl oxidase family (LOX, LOXL1-4) play in this process. He is also interested in the development of therapeutic agents to target inflammatory liver disease and works closely with clinical colleagues to facilitate the transition from bench to bedside.

Qualifications

  • PhD Biochemistry, Birmingham 2001
  • BSc Biochemistry with Biotechnology, Birmingham 1998

Biography

Dr Weston graduated in Biochemistry with Biotechnology from the University of Birmingham in 1998. He then completed a PhD in Biochemistry at Birmingham in the laboratory of Professor Baz Jackson working on the transhydrogenase of Entamoeba histolytica which controls the balance of reducing equivalents, as NAD(H) and NADP(H), in the cell.

He then took up a post-doctoral position shared between the Schools of Biosciences and Chemistry at Birmingham working on small catalytic peptides and DNA-binding proteins with Dr Oliver Smart and Professor Rudolf Allemann.

Chris joined the NIHR Biomedical Research Unit Centre for Liver Research in 2004, working with Professor David Adams on the mechanisms of inflammatory cell recruitment in chronic liver disease and is currently involved in projects ranging from the establishment of fibrosis, tumour immunology, leukocyte recruitment to hepatic manifestations of the metabolic syndrome. He currently holds a HEFCE funded position investigating the role of immune mediators in hepatic inflammation and disease progression, and is lead investigator of the amine oxidase research group.

Teaching

Postgraduate supervision

Chris is interested in supervising doctoral research students in the following areas:

  • The role of amine oxidases in liver disease and primary liver cancer
  • Lymphocyte recruitment to the human liver

If you are interesting in studying any of these subject areas please contact Chris on the contact details above, or for any general doctoral research enquiries, please email: dr@contacts.bham.ac.uk or call +44 (0)121 414 5005.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

RESEARCH THEMES

Chronic and acute inflammation, liver immunology, clinical trials, amine oxidases, fibrosis, tumour immunology

RESEARCH ACTIVITY

The establishment of chronic liver disease results from a persistence of hepatic insult leading to inflammation and scarring (fibrosis). Lymphocyte recruitment to the injured liver is mediated by specialised endothelial cells that line the liver blood channels (sinusoids). Dr Weston’s research focus is the study of the complex interactions between liver infiltrating immune cells and the hepatic endothelium using flow-based adhesion assays, confocal microscopy and transfection technologies. As part of this research Chris is exploring the role of amine oxidases, such as vascular adhesion protein-1 (VAP-1), in the establishment of liver disease and determining their contribution to the development of hepatic inflammation and fibrosis in vivo and in vitro. The aims of these research activities are the identification of novel biomarkers of hepatic injury and the development of therapeutic agents for the treatment of chronic liver disease.

Patent: “Use of VAP-1 inhibitors for treating fibrotic conditions (WO/2011/029996)”

Other activities

  • Membership of the British Association for the Study of the Liver
  • STEM ambassador to promote Science and Technology for children and young people

Publications

Zimmermann HW, Bruns T, Weston CJ, Curbishley SM, Liaskou E, Li KK, Resheq YJ, Badenhorst PW and Adams DH (2016) Bidirectional transendothelial migration of monocytes across hepatic sinusoidal endothelium shapes monocyte differentiation and regulates the balance between immunity and tolerance in liver. Hepatology 63(1):233-46

Stone LC, Thorne LS, Weston CJ, Graham M and Hodges NJ (2015) Cytoglobin expression in the hepatic stellate cell line HSC-T6 is regulated by extracellular matrix proteins dependent on FAK signalling. Fibrogenesis Tissue Repair 8:15

Wilhelm A, Aldridge V, Haldar, D, Naylor, AJ, Weston CJ, Garg A, Fear J, Reynolds GM, Croft AP, Henderson NC, Buckley CD and Newsome PN (2015) CD248/Endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF regulated mechanism. Gut [Epub ahead of print]

Bruns T, Zimmermann HW, Pachino A, Li KK, Trivedi PJ, Reynolds G, Hubscher S, Stamataki Z, Badenhorst PW, Weston CJ, Moss PA and Adams DH (2015) CMV infection of human hepatic sinusoidal endothelium regulates hepatic T-cell recruitment and activation. J Hepatol 63(1):38-49

Resheq YJ, Li KK, Ward ST, Wilhelm A, Garg A, Curbishley SM, Blahova M, Zimmermann HW, Jitschin R, Mougiakakos D, Mackensen A, Weston CJ* and Adams DH* (* joint senior authorship) (2015) Contact-dependent Depletion of H2O2 by Catalase is a novel Mechanism of Myeloid-Derived Suppressor Cell Induction Operating in Human Hepatic Stellate Cells. J Immunol 194(6):2578-86

Weston CJ*, Shepherd EL*, Claridge LC*, Rantakari P, Curbishley SM, Tomlinson JW, Hubscher SG, Reynolds GM, Aalto K, Anstee QM, Jalkanen S, Salmi M, Smith DJ, Day CP and Adams DH (* joint first authorship) (2015) Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis. J Clin Invest 125(2):501-20

Bernsmeier C, Pop OT, Singanayagam A, Triantafyllou E, Patel VC, Weston CJ, Curbishley S, Sadiq F, Vergis N, Khamri W, Bernal W, Auzinger G, Heneghan M, Ma Y, Jassem W, Heaton ND, Adams DH, Quaglia A, Thursz MR, Wendon J and Antoniades CG (2015) Patients with acute on chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK. Gastroenterology 148(3):603-15.e14

Ward ST, Li KK, Hepburn E, Weston CJ, Curbishley SM, Reynolds GM, Hejmadi R, Bicknell R, Eksteen B, Ismail T, Rot A and Adams DH (2015) The effects of CCR5 inhibition on regulatory T cell recruitment to colorectal cancer. Br J Cancer 112(2):319-28