Professor Carl Clarke

Professor Carl Clarke

Institute of Applied Health Research
Professor of Clinical Neurology
Honorary Consultant Neurologist

Contact details

Address
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Professor Clarke has a long history of research in Parkinson's disease and headache disorders. He runs large pragmatic clinical trials examining medical, surgical and rehabilitation interventions in Parkinson's disease (PD MED, PD SURG, PD REHAB, PD COMM and PD GEN).

Qualifications

  • FRCP
  • MD
  • MB ChB
  • BSc

Teaching

  • Instigator and co-ordinator of Birmingham Movement Disorders Course

Research

Professor Clarke has performed a wide variety of research work in Parkinson's disease over the last 30 years. This includes work on the MPTP primate model of the condition, examination of several potential diagnostic tests, systematic reviews of clinical trials in Parkinson's disease, and work on the effects of Parkinson's disease on quality of life and health economics. He led large pragmatic clinical trials examining medical, surgical and rehabilitation interventions in the condition (PD MED, PD SURG, PD REHAB and PD GEN). He was also the clinical advisor to the Technical Team preparing the NICE 2006 Parkinson's disease guidelines.

Other activities

  • Movement disorders clinics at City Hospital, Birmingham, Sandwell and West Birmingham Hospitals NHS Trust.
  • Director of Research and Development, Sandwell and West Birmingham Hospitals NHS Trust 2010-14.
  • Deputy Chair of NIHR Efficacy and Mechanisms Evaluation Board 2014-18.

Publications

Recent publications

Article

Sackley, C, Rick, C, Au, P, Brady , MC, Beaton , G, Burton, C, Caulfield, M, Dickson , S, Dowling, F, Hughes, M, Rowland, N, Jowett, S, Masterson-Algar, P, Nicoll , A, Patel, S, Smith , CH, Woolley, R & Clarke, CE 2020, 'A multi-centre randomised controlled trial to compare the clinical and cost effectiveness of Lee Silverman voice treatment versus standard NHS speech and language therapy versus control in Parkinson’s disease: a study protocol for a randomised controlled trial', Trials, vol. 21, no. 1, 436. https://doi.org/10.1186/s13063-020-04354-7

Lang, AE, de Bie, RMA, Clarke, CE, Espay, AJ & Fox, SH 2020, 'Initiating pharmacotherapy in early Parkinson's disease', The Lancet Neurology, vol. 19, no. 8, pp. 643-644. https://doi.org/10.1016/S1474-4422(20)30225-8

Herd, C, Tomlinson, C, Rick, C, Scotton, W, Edwards, J, Ives, N, Clarke, CE & Sinclair, A 2019, 'Cochrane systematic review and meta-analysis of Botulinum toxin for the prevention of migraine', BMJ open, vol. 9, no. 7, e027953. https://doi.org/10.1136/bmjopen-2018-027953

Smith, CH, Patel, S, Woolley, RL, Brady, MC, Rick, CE, Halfpenny, R, Rontiris, A, Knox-Smith, L, Dowling, F, Clarke, CE, Au, P, Ives, N, Wheatley, K & Sackley, CM 2019, 'Rating the intelligibility of dysarthic speech amongst people with Parkinson's Disease: a comparison of trained and untrained listeners', Clinical Linguistics & Phonetics, vol. 33, no. 10-11, pp. 1063-1070. https://doi.org/10.1080/02699206.2019.1604806

American Genome Center 2019, 'The Genetic Architecture of Parkinson Disease in Spain: Characterizing Population-Specific Risk, Differential Haplotype Structures, and Providing Etiologic Insight', Movement Disorders, vol. 34, no. 12, pp. 1851-1863. https://doi.org/10.1002/mds.27864

Herd, C, Cl, T, Rick, C, Scotton, WJ, Edwards, J, Ives, N, Clarke, CE & Sinclair, A 2018, 'Botulinum toxins for the prevention of migraine in adults', Cochrane Database of Systematic Reviews, no. 6, CD011616. https://doi.org/10.1002/14651858.CD011616.pub2

Sackley, CM, Smith, CH, Rick, C, Brady, MC, Ives, N, Patel, S, Woolley, R, Dowling, F, Patel, R, Roberts, H, Jowett, S, Wheatley, K, Kelly, D, Sands, G, Clarke, CE & PD COMM Pilot Collaborative Group 2018, 'Lee Silverman Voice Treatment versus standard speech and language therapy versus control in Parkinson’s disease: a pilot randomised controlled trial (PD COMM pilot)', Pilot and Feasibility Studies, vol. 4, no. 30. https://doi.org/10.1186/s40814-017-0222-z

Muzerengi, S, Rick, C, Begaj, I, Ives, N, Evison, F, Woolley, RL & Clarke, CE 2017, 'Coding accuracy for Parkinson's disease hospital admissions: implications for healthcare planning in the UK', Public Health, vol. 146, pp. 4-9. https://doi.org/10.1016/j.puhe.2016.12.024

Masterson-Algar, P, Burton, CR, Brady, MC, Nicoll, A, Clarke, CE, Rick, C, Hughes, M, Au, P, Smith, CH & Sackley, CM 2017, 'The PD COMM trial: a protocol for the process evaluation of a randomised trial assessing the effectiveness of two types of SLT for people with Parkinson's disease', Trials, vol. 18, no. 1, pp. 397. https://doi.org/10.1186/s13063-017-2130-1

Muzerengi, S, Herd, C, Rick, C & Clarke, CE 2016, 'A systematic review of interventions to reduce hospitalisation in Parkinson's disease', Parkinsonism and Related Disorders. https://doi.org/10.1016/j.parkreldis.2016.01.011

Clarke, CE, Patel, S, Ives, N, Rick, CE, Woolley, R, Wheatley, K, Walker, MF, Zhu, S, Kandiyali, R, Yao, G & Sackley, CM 2016, 'Clinical effectiveness and cost-effectiveness of physiotherapy and occupational therapy versus no therapy in mild to moderate Parkinson's disease: a large pragmatic randomised controlled trial (PD REHAB)', Health Technology Assessment, vol. 20, no. 63, pp. 1-124. https://doi.org/10.3310/hta20630

Spurgeon, L, Clarke, CE & Sackley, C 2016, 'Corrigendum to "Subjective Experiences of Speech and Language Therapy in Patients with Parkinson's Disease: A Pilot Study"', Rehabilitation research and practice, vol. 2016, pp. 1654282. https://doi.org/10.1155/2016/1654282

Mok, KY, Sheerin, U, Simón-Sánchez, J, Salaka, A, Chester, L, Escott-Price, V, Mantripragada, K, Doherty, KM, Noyce, AJ, Mencacci, NE, Lubbe, SJ, Williams-Gray, CH, Barker, RA, van Dijk, KD, Berendse, HW, Heutink, P, Corvol, J-C, Cormier, F, Lesage, S, Brice, A, Brockmann, K, Schulte, C, Gasser, T, Foltynie, T, Limousin, P, Morrison, KE, Clarke, CE, Sawcer, S, Warner, TT, Lees, AJ, Morris, HR, Nalls, MA, Singleton, AB, Hardy, J, Abramov, AY, Plagnol, V, Williams, NM, Wood, NW & International Parkinson's Disease Genomics Consortium (IPDGC) 2016, 'Deletions at 22q11.2 in idiopathic Parkinson's disease: a combined analysis of genome-wide association data', The Lancet Neurology. https://doi.org/10.1016/S1474-4422(16)00071-5

Review article

de Bie, RMA, Clarke, CE, Espay, AJ, Fox, SH & Lang, AE 2020, 'Initiation of pharmacological therapy in Parkinson's disease: when, why, and how', The Lancet Neurology, vol. 19, no. 5, pp. 452-461. https://doi.org/10.1016/S1474-4422(20)30036-3

Herd, CP, Tomlinson, CL, Rick, C, Scotton, WJ, Edwards, J, Ives, N, Clarke, CE & Sinclair, A 2018, 'Botulinum toxins for the prevention of migraine in adults', Cochrane Database of Systematic Reviews, vol. 6, CD011616. https://doi.org/10.1002/14651858.CD011616.pub2

View all publications in research portal

Expertise

Parkinson's Disease