Dr Adam Devall BMedSc (Hons), PhD

Dr Adam Devall

Institute of Applied Health Research
Trials Management Team Leader, Birmingham Clinical Trials Unit (BCTU)
Senior Clinical Trials Fellow, Tommy's National Centre for Miscarriage Research

Contact details

Birmingham Clinical Trials Unit
Public Health Building
University of Birmingham
University of Birmingham
B15 2TT

Adam's primary research focus is clinical trials in early pregnancy care, with a particular focus on miscarriage, infertility and global women’s health. He has a split role within the organisation, working as a Trials Management Team Leader at the Birmingham Clinical Trials Unit and as a Senior Clinical Trials Fellow in the Tommy's National Centre for Miscarriage Research, led by Prof Arri Coomarasamy.


  • PhD in Neuroscience, University of Birmingham, 2007
  • BMedSc (Hons) Pharmacology, University of Birmingham, 2003


Adam Devall qualified with a BMedSc (Hons) in Medical Sciences from the University of Birmingham in 2003. He went on to study for a PhD in the Department of Pharmacology at Birmingham, which he was awarded in 2007. Following this, he took a position as a Research Fellow at the University of Birmingham in the Department of Neurobiology and Neuropharmacology before taking up the role of Trial Coordinator at the Cancer Research Clinical Trials Unit, University of Birmingham in 2011. In 2014, Adam moved to the Birmingham Clinical Trials Unit, working as the Senior Trial Manager for the PRISM trial. In 2016, Adam transitioned to his current role of Team Leader/Senior Clinical Trials Fellow.


Recent publications


Roberts, T, Okeke Ogwulu, D, Goranitis, I, Devall, A, Cheed, V, Gallos, I, Middleton, L, Harb, H, Williams, H, Eapen, A, Daniels, J, Ahmed, A, Bender atik, R, Bhatia, K, bottomley, C, Ewer, A & Coomarasamy, A 2020, 'The cost-effectiveness of progesterone in preventing miscarriages in women with early pregnancy bleeding: an economic evaluation based on the PRISM Trial', BJOG: An International Journal of Obstetrics & Gynaecology. https://doi.org/DOI: 10.1111/1471-0528.16068

Coomarasamy, A, Devall, AJ, Cheed, V, Harb, H, Middleton, LJ, Gallos, ID, Williams, H, Eapen, AK, Roberts, T, Ogwulu, CC, Goranitis, I, Daniels, JP, Ahmed, A, Bender-Atik, R, Bhatia, K, Bottomley, C, Brewin, J, Choudhary, M, Crosfill, F, Deb, S, Duncan, WC, Ewer, A, Hinshaw, K, Holland, T, Izzat, F, Johns, J, Kriedt, K, Lumsden, M-A, Manda, P, Norman, JE, Nunes, N, Overton, CE, Quenby, S, Rao, S, Ross, J, Shahid, A, Underwood, M, Vaithilingam, N, Watkins, L, Wykes, C, Horne, A & Jurkovic, D 2019, 'A randomized trial of progesterone in women with bleeding in early pregnancy', The New England Journal of Medicine, vol. 380, no. 19, pp. 1815-1824. https://doi.org/10.1056/NEJMoa1813730

Tan, WS, Panchal, A, Buckley, L, Devall, AJ, Loubière, LS, Pope, AM, Feneley, MR, Cresswell, J, Issa, R, Mostafid, H, Madaan, S, Bhatt, R, McGrath, J, Sangar, V, Griffiths, TRL, Page, T, Hodgson, D, Datta, SN, Billingham, LJ & Kelly, JD 2018, 'Radiofrequency-induced thermo-chemotherapy effect versus a second course of Bacillus Calmette-Guérin or institutional standard in patients with recurrence of non–muscle-invasive bladder cancer following induction or maintenance Bacillus Calmette-Guérin therapy (HYMN): a phase III, open-label, randomised controlled trial', European urology. https://doi.org/10.1016/j.eururo.2018.09.005

Dowell, A, Cobby, E, Wen, K, Devall, A, During, V, Anderson, J, James, N, Cheng, K, Zeegers, M, Bryan, R & Taylor, G 2017, 'Interleukin-17-positive mast cells influence outcomes from BCG for patients with CIS: data from a comprehensive characterisation of the immune microenvironment of urothelial bladder cancer', PLoS ONE, vol. 12, no. 9, e0184841. https://doi.org/10.1371/journal.pone.0184841

Togneri, F, Ward, D, Foster, J, Devall, A, Wojtowicz, P, Alyas, S, Ramos Vasques, F, Oumie, A, James, N, Cheng, K, Zeegers, M, Deshmukh, N, O'Sullivan, B, Taniere, P, Spink, K, McMullan, D, Griffiths, M & Bryan, R 2016, 'Genomic complexity of urothelial bladder cancer revealed in urinary cfDNA', European Journal of Human Genetics, vol. 24, pp. 1167–1174. https://doi.org/10.1038/ejhg.2015.281

Kitchen, M, Bryan, R, Emes, RD, Glossop, J, Luscombe, C, Cheng, K, Zeegers, M, James, N, Devall, A, Mein, CA, Gommersall, L, Fryer, A & Farrell, WE 2016, 'Quantitative genome-wide methylation analysis of high-grade non-muscle invasive bladder cancer', Epigenetics : official journal of the DNA Methylation Society, vol. 11, no. 3. https://doi.org/10.1080/15592294.2016.1154246

Devall, AJ, dos Santos, J, Fry, JP, Honour, JW, Brandão, ML & Lovick, TA 2015, 'Elevation of brain allopregnanolone rather than 5-HT release by short term, low dose fluoxetine treatment prevents the estrous cycle-linked increase in stress sensitivity in female rats', European Neuropsychopharmacology, vol. 25, no. 1, pp. 113-123. https://doi.org/10.1016/j.euroneuro.2014.11.017

Kitchen, MO, Bryan, RT, Haworth, KE, Emes, RD, Luscombe, C, Gommersall, L, Cheng, KK, Zeegers, MP, James, ND, Devall, AJ, Fryer, AA & Farrell, WE 2015, 'Methylation of HOXA9 and ISL1 Predicts Patient Outcome in High-Grade Non-Invasive Bladder Cancer', PLoS ONE, vol. 10, no. 9, e0137003. https://doi.org/10.1371/journal.pone.0137003

Bryan, RT, Regan, HL, Pirrie, SJ, Devall, AJ, Cheng, KK, Zeegers, MP, James, ND, Knowles, MA & Ward, DG 2015, 'Protein shedding in urothelial bladder cancer: prognostic implications of soluble urinary EGFR and EpCAM', British Journal of Cancer, vol. 112, no. 6, pp. 1052-8. https://doi.org/10.1038/bjc.2015.21

Bryan, RT, Shimwell, NJ, Wei, W, Devall, AJ, Pirrie, SJ, James, ND, Zeegers, MP, Cheng, KK, Martin, A & Ward, DG 2014, 'Urinary EpCAM in urothelial bladder cancer patients: characterisation and evaluation of biomarker potential', British Journal of Cancer, vol. 110, no. 3, pp. 679-85. https://doi.org/10.1038/bjc.2013.744

Wright, T, Devall, A, Pirrie, S, Billingham, L, Cheng, KK, Zeegers, M, Bryan, R & James, ND 2013, 'Muscle invasive bladder cancer in the elderly: Treatment and prognosis in a prospective cohort study', Journal of Clinical Oncology , vol. 31, no. 6_suppl, pp. 275. https://doi.org/10.1200/jco.2013.31.6_suppl.275

Devall, A, Santos, JM & Lovick, T 2011, 'Estrous cycle influences on neuronal responsiveness to repeated anxiogenic stress in female rats', Behavioural Brain Research, vol. 225, no. 1, pp. 334-340. https://doi.org/10.1016/j.bbr.2011.07.038


Kitchen, M, Bryan, R, Emes, RD, Glossop, J, Luscombe, C, Cheng, K, Zeegers, M, James, N, Devall, A, Mein, CA & Gommersall, L 2016, 'Quantitative genome-wide methylation analysis of high-grade non-muscle invasive bladder cancer', European Urology Supplements, vol. 15, no. 3, pp. e936. https://doi.org/10.1016/S1569-9056(16)60938-7


Devall, A, Fry, JP, Honour, JW & Lovick, T 2011, 'Brain progesterone metabolism in rats following acute fluoxetine treatment: sex differences and anxiolytic effects in females', Paper presented at Scientific Meeting of the Physiological Society, 23rd, Oxford, United Kingdom, 1/01/11 pp. PC11.

Review article

Coomarasamy, A, Devall, AJ, Brosens, JJ, Quenby, S, Stephenson, MD, Sierra, S, Christiansen, OB, Small, R, Brewin, J, Roberts, TE, Dhillon-Smith, R, Harb, H, Noordali, H, Papadopoulou, A, Eapen, A, Prior, M, Di Renzo, GC, Hinshaw, K, Mol, BW, Lumsden, MA, Khalaf, Y, Shennan, A, Goddijn, M, van Wely, M, Al-Memar, M, Bennett, P, Bourne, T, Rai, R, Regan, L & Gallos, ID 2020, 'Micronized vaginal progesterone to prevent miscarriage: a critical evaluation of randomized evidence', American journal of obstetrics and gynecology, vol. 223, no. 2, pp. 167-176. https://doi.org/10.1016/j.ajog.2019.12.006

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