Diagnostic research; systematic review methodology
Biomarkers for monitoring
She is currently working on an NIHR funded project evaluating the benefits of new and existing biological fluid biomarkers in liver and renal disease. She is focusing on the methodological component of the Programme Grant under the supervision of Professor Jon Deeks. The aim is to develop a framework that defines the minimum evidence required to justify and guide the use of biomarkers within formal monitoring rules or strategies.
Diagnostic test evaluations
Her interest in diagnostic test research is longstanding. She contributed to the development of the QUADAS tool (Quality Assessment of Diagnostic Accuracy Studies) and more recently completed her PhD on the effect of patient spectrum (case-mix) on diagnostic test accuracy. This included a thorough review of how heterogeneity has been examined in systematic reviews of diagnostic test accuracy, a comparison of three statistical methods for the meta-analysis of diagnostic accuracy studies and a meta-regression using a large sample of previously published systematic reviews of diagnostic tests to identify the influence of spectrum-related covariates.
Evaluating non-randomised intervention studies
Her other methodological interest lies in the evaluation of non-randomised intervention studies. She carried out a review of whether and how quality has been assessed in systematic reviews that included non-randomised studies and conducted a thorough evaluation of available quality assessment tools for non-randomised studies, assessing them against pre-specified internal validity domains.