Ms Janine Dretzke

Ms Janine Dretzke

Institute of Applied Health Research
Senior Systematic Reviewer

Contact details

Address
Biostatistics, Evidence Synthesis and Test Evaluation (BESaTE)
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Janine has considerable experience in conducting evidence syntheses, systematic reviews, meta-analyses and health technology assessments (HTA) to inform local and national healthcare decision making. Research outputs include reports commissioned by the National Institute for Health and Care Excellence (NICE) and the NIHR Health Technology Assessment (HTA) Programme. Janine has an interest in evidence synthesis methodologies as applied to different types of health care questions and study designs (e.g. effectiveness, test accuracy, adverse events, prognostic factors and models).  Janine lectures in study design and the methodology of undertaking evidence syntheses and is a module coordinator of the Systematic Reviews and Evidence Synthesis module (MPH (HTA)).

Qualifications

  • MSc Health Technology Assessment (University of Birmingham 2003)
  • MSc Environmental Management (University of Stirling 1996)
  • BSc Biological Sciences with Microbiology (University of Warwick 1995)

Biography

Following a degree in Biological Sciences and an MSc in Environmental Management, Janine first worked in a number of environmental consultancies and then in a small business technology transfer role. She joined the University of Birmingham to undertake technology assessment reports (TARs) and single technology appraisals (STAs) commissioned by the National Institute for Health and Care Excellence (NICE). Whilst undertaking this role she completed a part-time MSc in Health Technology Assessment. She has since undertaken evidence syntheses and systematic reviews for a variety of customers and in a range of clinical areas (e.g. cardiovascular, trauma). She has developed an interest in systematic review methodology as applied to different type of clinical questions and study designs. Janine also teaches and supervises undergraduates and postgraduates and is a module coordinator for the Systematic Reviews and Evidence Synthesis module. She is a Fellow of the Higher Education Academy.

Teaching

Postgraduate supervision

Master's level dissertations related to evidence synthesis

Research

Research groups and centres:

  • Biostatistics, Evidence Synthesis and Test Evaluation team (BESaTE)

Other activities

Module coordinator for the Systematic Reviews and Evidence Synthesis Module of the MPH (HTA)

Publications

Farooq S, Khandavilli S, Dretzke J, Moore D, Nankivell PC, Sharma N, de Almeida JR, Winter SC, Simon C, Paleri V, De M, Siddiq S, Holsinger FC, Ferris RL, Mehanna H. Transoral tongue base mucosectomy for the identification of the primary site in the work-up of cancers of unknown origin: Systematic review and meta-analysis. Oral Oncology. Volume 91, April 2019, Pages 97-106 https://www.sciencedirect.com/science/article/pii/S1368837519300624

Beese SE, Harris IM, Dretzke J, Moore D. Body image dissatisfaction in patients with inflammatory bowel disease: a systematic review BMJ Open Gastroenterology 2019;6:e000255. doi: 10.1136/bmjgast-2018-000255 https://bmjopengastro.bmj.com/content/6/1/e000255

Patel V, Champaneria R, Dretzke J, Yeung J. Effect of regional versus general anaesthesia on postoperative delirium in elderly patients undergoing surgery for hip fracture: a systematic review BMJ Open 2018;8:e020757. doi: 10.1136/bmjopen-2017-020757 

Beese SE, Harris IM, Moore D, Dretzke J. Body image dissatisfaction in patients with inflammatory bowel disease: a systematic review protocol. Systematic Reviews 2018 7:184 https://doi.org/10.1186/s13643-018-0844-0

Bennett PM, Stewart SK, Dretzke J, Bem D, Penn-Barwell JG (2018) Preclinical therapies to prevent or treat fracture non-union: A systematic review. PLOS ONE 13(8): e0201077. https://doi.org/10.1371/journal.pone.0201077

Nieto T, Tomlinson CL, Dretzke J, Bayliss S, Price MJ, Dilworth M, Beggs AD, Tucker O. A systematic review of epigenetic biomarkers in progression from non-dysplastic Barrett’s oesophagus to oesophageal adenocarcinoma BMJ Open 2018;8:e020427. https://bmjopen.bmj.com/content/8/6/e020427

Halstead FD, Chear Lee K, Kwei J, Dretzke J, Oppenheim BA, Moiemen NS. A systematic review of quantitative burn wound microbiology in the management of burns patients Burns 2018; 44(1):39-56 https://www.sciencedirect.com/science/article/pii/S0305417917303601?via%3Dihub

Naumann D, Beaven A, Dretzke J, Hutchings S, Midwinter MJ.Searching or the Optimal Fluid to Restore Microcirculatory Flow Dynamics After Haemorrhagic Shock: A Systematic Review of Preclinical Studies Shock: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches, Volume 46, Number 6, December 2016, pp. 609-622(14) https://www.ingentaconnect.com/content/wk/shk/2016/00000046/00000006/art00003

Nieto T, Tomlinson C, Dretzke J, Bayliss S, Dilworth M, Beggs AD, Tucker O. Epigenetic biomarkers in progression from non-dysplastic Barrett’s Oesophagus to Oesophageal Adenocarcinoma: A Systematic Review protocol. BMJ Open 2016;6: e013361 doi:10.1136/bmjopen-2016-013361 https://bmjopen.bmj.com/content/6/12/e013361

Smith IM, James RH, Dretzke J, Midwinter MJ. Prehospital Blood Product Resuscitation for Trauma: A Systematic Review. Shock. 2016;46(1):3-16. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933578/

Dretzke J, Moore D, Dave C, Mukherjee R, Price M, Bayliss S, Wu X, Jordan R, Turner AM. The effect of domiciliary non-invasive ventilation (NIV) on clinical outcomes in stable and recently hospitalised patients with severe obstructive pulmonary disease (COPD): a systematic review and meta-analysis. Int J Chron Obstruct Pulmon Dis. 2016; 11: 2269–2286. https://www.ncbi.nlm.nih.gov/pubmed/27698560

Bem D, Lordkipanidzé M, Hodgkinson J, Stevens S, Bayliss S, Moore D, Fitzmaurice D, Dretzke J.The effect of different aspirin dosing regimens for the prevention of primary and secondary cardiovascular disease: A systematic review. Clin Pharmacol Ther. 2016 Nov;100(5):500-512. doi: 10.1002/cpt.438. Epub 2016 Sep 19. https://ascpt.onlinelibrary.wiley.com/doi/full/10.1002/cpt.438

Chaudhary R, Dretzke J, Scott R, Logan A, Blanch R. Clinical and surgical risk factors in the development of proliferative vitreoretinopathy following retinal detachment surgery: a systematic review protocol. Systematic Reviews 2016, 5:107  https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-016-0284-7

Chear Lee K, Dretzke J, Grover L, Logan A, Moiemen N. A systematic review of objective burn scar Measurements. Burns & Trauma (2016) 4:14 DOI 10.1186/s41038-016-0036-x https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964074/

Yeung J, Patel V, Champaneria R, Dretzke J. Regional versus general anaesthesia in elderly patients undergoing surgery for hip fracture: protocol for a systematic review. Systematic Reviews 2016; 5:66 DOI: 10.1186/s13643-016-0246-0 https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-016-0246-0

Stewart SK, Bennett PM, Stapley SA, Dretzke J, Bem D, Penn-Barwell JG. Pre-clinical evaluation of therapies to prevent or treat bone non-union: a systematic review protocol. Syst Rev. 2015 Nov 12;4(1):161. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643533/

Kwei J, Halstead FD, Dretzke J, Oppenheim BA, Moiemen NS. Protocol for a systematic review of quantitative burn wound microbiology in the management of burns patients. Syst Rev. 2015 Nov 6;4:150. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635620/

Dretzke J,  Blissett D, Dave C, Mukherjee R, Price M, Bayliss S, Wu X, Jordan R, Jowett S, Turner A, Moore D. The cost-effectiveness of domiciliary non-invasive ventilation (NIV) in patients with end-stage COPD. A systematic review and economic evaluation. Health Technol Assess 2015; 19 (81)  https://www.journalslibrary.nihr.ac.uk/hta/hta19810/#/abstract

Naumann DN, Dretzke J, Hutchings S, Midwinter MJ.  Protocol for a systematic review of the impact of resuscitation fluids on the microcirculation after haemorrhagic shock in animal models. Systematic Reviews 2015;4: 135. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593218/

Bem D, Dretzke J, Stevens S, Lordkipanidzé M, Hodgkinson J, Bayliss S, Moore D, Fitzmaurice D. Investigating the effectiveness of different aspirin dosing regimens and the timing of aspirin intake in primary and secondary prevention of cardiovascular disease: protocol for a systematic review. Systematic Reviews 2015, 4:88 doi:10.1186/s13643-015-0078-3https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475616/

 

Dretzke J, Riley RD, Lordkipanidzé M, Jowett S, O'Donnell J, Ensor J, et al. The prognostic utility of tests of platelet function for the detection of aspirin resistance in patients with established cardiovascular or cerebrovascular disease: a systematic review and economic evaluation. Health Technol Assess 2015;19 (37) https://www.journalslibrary.nihr.ac.uk/hta/hta19370/#/abstract

Chen YF, Bramley G, Unwin G, Hanu-Cernat D, Dretzke J, Moore D, Bayliss S2 Cummins C, Lilford R. Occipital nerve stimulation for chronic migraine - a systematic review and meta-analysis. PLoS One. 2015; 10 (3):e0116786. doi: 10.1371/journal.pone.0116786  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116786

Dretzke J, Ensor J, Bayliss S, Hodgkinson J, Lordkipanidzé M, Richard RD, Fitzmaurice D, Moore D. Methodological issues and recommendations for systematic reviews of prognostic studies: an example from cardiovascular disease. Systematic Reviews 2014, 3:140  doi:10.1186/2046-4053-3-140  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265412/

Dave C, Turner A, Dretzke J, Bayliss S, O’Brien D, Jowett S, Moore D. Protocol for a systematic review and economic evaluation of the clinical and cost-effectiveness of non-hospital based non-invasive ventilation (NIV) in patients with stable end stage COPD with hypercapnic respiratory failure; Systematic Reviews 2014; 3:32. doi: 10.1186/2046-4053-3-32. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977879/

Dretzke J, Smith IM, James R, Midwinter MJ. Protocol for a systematic review of the clinical effectiveness of pre-hospital blood components compared to other resuscitative fluids in patients with major traumatic haemorrhage. Systematic Reviews 2014, 3:123  doi:10.1186/2046-4053-3-123 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224592/

Dretzke J,  Meadows A, Novielli N, Huissoon A, Fry-Smith A, Meads C. Subcutaneous and sublingual immunotherapy for seasonal allergic rhinitis: A systematic review and indirect comparison. Journal of Allergy & Clinical Immunology 2013; 131(5):1361-6. https://www.jacionline.org/article/S0091-6749(13)00323-0/abstract

Raichand S, Moore D, Riley R, Lordkipanidzé M, Dretzke J, O'Donnell J, Jowett S, Bayliss S and Fitzmaurice D.  Protocol for a systematic review of the diagnostic and prognostic utility of tests currently available for the detection of aspirin resistance in patients with established cardiovascular or cerebrovascular disease. BMC Systematic Reviews 2013, 2:16   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600664/

Michelson, D., Davenport, C., Dretzke, J., Barlow, J. & Day, C. Do evidence-based interventions work when tested in the real world? A systematic review and meta-analysis of parent management training for the treatment of child disruptive behaviour. Clinical Child and Family Psychology Review. 2013;16(1):18-34 https://www.ncbi.nlm.nih.gov/pubmed/23420407

Meadows A, Kaambwa B, Novielli N, Huissoon A, Fry-Smith A, Meads C, Barton P, Dretzke J. A systematic review and economic evaluation of immunotherapy for seasonal allergic rhinitis. Health Technol Assess.2013;17(27) https://www.journalslibrary.nihr.ac.uk/hta/hta17270/#/abstract

Dretzke J, Edlin R, Round J, Connock M, Hulme C, Czeczot J, Fry-Smith A, McCabe C, Meads C. A systematic review and economic evaluation of the use of tumour necrosis factor-alpha (TNF-a) inhibitors, adalimumab and infliximab, for Crohn’s disease. Health Technol Assess 2011;15(6). https://www.journalslibrary.nihr.ac.uk/hta/hta15060/#/abstract

Dretzke J, Barton P, Kaambwa B, Connock M, Uthman O, Bayliss S, Meads C. Rituximab for the treatment of relapsed/refractory chronic lymphocytic leukaemia. Health Technol Assess 2010;14(Suppl. 2):19–26 https://www.journalslibrary.nihr.ac.uk/hta/hta14Suppl203/#/abstract

Dretzke J, Round J, Connock M, Tubeuf S, Pennant M, Fry-Smith A, Hulme C, McCabe C, Meads C. Imatinib as adjuvant treatment following resection of KIT-positive gastrointestinal stromal tumours .Health Technol Assess 2010;14(Suppl. 2):63–70  https://www.journalslibrary.nihr.ac.uk/programmes/hta/0823901/#/

Dretzke J, Davenport C, Frew E, Barlow J, Stewart-Brown S, Bayliss S, Taylor RS, Sandercock J, Hyde C. The clinical effectiveness of different parenting programmes for children with conduct problems: a systematic review of randomised controlled trials. Child Adolesc Psychiatry Ment Health. 2009;3(1):7.  https://www.ncbi.nlm.nih.gov/pubmed/19261188 

Roberts J, Huissoon A, Dretzke J, Wang D, Hyde C.A systematic review of the clinical effectiveness of acupuncture for allergic rhinitis. BMC Complement Altern Med. 2008;8:13. https://www.ncbi.nlm.nih.gov/pubmed/18430229

Bayliss SE, Dretzke J. Health technology assessment in social care: a case study of randomized controlled trial retrieval. Int J Technol Assess Health Care. 2006;22(1):39-46. https://www.ncbi.nlm.nih.gov/pubmed/16673679

Dretzke J, Burls A, Bayliss S, Sandercock J. The clinical effectiveness of pre-hospital intravenous fluid replacement in trauma patients without head injury: a systematic review. Trauma 2006;8:131-141 http://journals.sagepub.com/doi/abs/10.1177/1460408606071972

Connock M, Juarez-Garcia A, Frew E, Mans A, Dretzke J, Fry-Smith A, Moore D. A systematic review of the clinical effectiveness and cost-effectiveness of enzyme replacement therapies for Fabry's disease and mucopolysaccharidosis type 1. Health Technol Assess. 2006;10(20) https://www.journalslibrary.nihr.ac.uk/hta/hta10200#/abstract

Dretzke J, Frew E, Davenport C, Barlow J, Stewart-Brown S, Sandercock J, Bayliss S, Raftery J, Hyde C, Taylor R. The effectiveness and cost-effectiveness of parent training/education programmes for the treatment of conduct disorder, including oppositional defiant disorder, in children. Health Technology Assessment 2005; 9 (50) https://www.journalslibrary.nihr.ac.uk/hta/hta9500#/abstract

Dretzke J, Sandercock J, Bayliss S and Burls A. Clinical effectiveness and cost-effectiveness of pre-hospital intravenous fluids in trauma patients. Health Technol Assess 2004;8(23) https://www.journalslibrary.nihr.ac.uk/hta/hta8230#/abstract

Dretzke J, Cummins C, Sandercock J, Fry-Smith A, Barrett T and Burls A. Autoantibody testing in children with newly diagnosed type 1 diabetes mellitus. Health Technol Assess  2004;8(22) https://www.journalslibrary.nihr.ac.uk/hta/hta8220#/abstract

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