Dr Mike P Gardner BSc, PGCE, PhD

Dr Mike P Gardner

Institute of Applied Health Research
Research Fellow

Contact details

Address
Public Health, Epidemiology and Biostatistics
IOEM Building
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Mike Gardner is a Research Fellow in the Institute of Applied Health Research.

He has more than 10 years’ research experience in epidemiology, systematic reviewing, meta-analyses and health-related research. Mike is a Research Design Service (RDS) Advisor at the Birmingham Hub of the NIHR West Midlands RDS. In this role he provides advice to health and social care professionals on health related research proposals to national peer-reviewed funding programmes. He is undertaking research on chronic disease epidemiology. Currently Mike is investigating the associations of cardiovascular risk factors in HIV patients with cardiovascular disease burden

Qualifications

Research Fellow:

  • PhD in Biological Sciences, University of Exeter, 1996
  • PGCE in Science, University of York, 1989
  • BSc (Hons) in Biophysics, University of York, 1988

Biography

Mike has research experience in both epidemiology and biological sciences. He completed his PhD on the genetic basis of reproductive isolation in plants at the University of Exeter in the Department of Biological Sciences. He subsequently investigated the evolution of the fruit fly Drosophila melanogaster (University College London), the evolution and biology of ageing of nematode worms (University of Bristol) and investigated whether mitochondria recombined (University of Sussex).

From 2009-2014 Mike was an epidemiologist and a systematic reviewer at the School of Social Medicine, University of Bristol. As part of the Healthy Ageing across the Life Course Programme (Halcyon) (2009-2012) he examined the associations between the stress hormone cortisol and physical and cognitive function in older adults. He was part of the team that developed the new systematic review methodology for mechanistic studies for the WCRF/University of Bristol collaboration (2012-2014).

From 2014-2017 Mike was the research coordinator on a mixed method study investigating Comprehensive Geriatric Assessment (CGA) with individual patient data, as well as including a Delphi exercise and a national survey (Nuffield Department of Population Health (NDPH), University of Oxford). He also worked on an NDPH pump priming funded programme of work to apply a systematic review methodology to identify mechanisms underlying the relationship of meat intake with pancreatic cancer (2017-2018).

Mike is a Research Fellow at the Institute of Applied Health Research (2020). He is a Research Design Service (RDS) Advisor and is also carrying out research on chronic disease epidemiology.

He has taught on postgraduate short courses on concluding, reporting and critical appraisal of systematic reviews (University of Bristol, 2012-2014). He has also taught science at Secondary School (2018-2020). He has reviewed manuscripts for a range of journals, including ‘International Journal of Epidemiology’, ‘British Journal of Cancer’, ‘BMC Women’s Health’ and ‘BMJ Open’.

Research

Research Themes

Mike is interested in chronic disease epidemiology, including i) cardiovascular disease epidemiology and ii) dysregulation of the hypothalamic pituitary adrenal axis (HPA) (which secretes the stress hormone cortisol).

He is also interested in systematic review methodology, including for mechanistic studies (including human, animal and cell experimental studies).

Mike’s current and previous projects include:

Cardiovascular Disease Epidemiology

He is investigating the associations of cardiovascular risk factors in HIV patients with cardiovascular disease burden.

Systematic review methodology for mechanistic studies for the WCRF/University of Bristol collaboration

We developed a two-stage framework, for identifying and carrying out systematic reviews of mechanisms of exposure–cancer associations.

Comprehensive Geriatric Assessment

A mixed methods health services research study investigating Comprehensive Geriatric Assessment in hospital and hospital-at home settings. The project included an update of a Cochrane Review, a Delphi exercise and a national survey.

Healthy Ageing across the Life Course Programme (Halcyon)

Mike examined the associations between the stress hormone cortisol and physical and cognitive function in older adults. We found that higher cortisol levels across the day were associated with worse physical and cognitive function in older adults.

Research Groups and Centres

https://www.birmingham.ac.uk/research/activity/applied-health/index.aspx

Key Words

Ageing, Cardiovascular Disease, Cortisol, Epidemiology, Meta-analyses, Systematic Reviews.

Publications

Recent publications

Article

Gardner, M, Shepperd, S, Godfrey, M, Mäkelä, P, Tsiachristas, A, Singh-mehta, A, Ellis, G, Khanna, P, Langhorne, P, Makin, S & Stott, DJ 2019, 'Comprehensive Geriatric Assessment in hospital and hospital-at-home settings: a mixed-methods study', Health Services and Delivery Research, vol. 7, no. 10, pp. 1-206. https://doi.org/10.3310/hsdr07100

Gardner, M, Lightman, S, Kuh, D, Comijs, H, Deeg, D, Gallacher, J, Geoffroy, M-C, Kivimaki, M, Kumari, M, Power, C, Hardy, R, Richards, M & Ben-Shlomo, Y 2019, 'Dysregulation of the hypothalamic pituitary adrenal (HPA) axis and cognitive capability at older ages: individual participant meta-analysis of five cohorts', Scientific Reports, vol. 9, no. 1, 4555. https://doi.org/10.1038/s41598-019-40566-x

Ellis, G, Gardner, M, Tsiachristas, A, Langhorne, P, Burke, O, Harwood, RH, Conroy, SP, Kircher, T, Somme, D, Saltvedt, I, Wald, H, O'neill, D, Robinson, D & Shepperd, S 2017, 'Comprehensive geriatric assessment for older adults admitted to hospital', Cochrane Library, vol. 2017, no. 9, CD006211. https://doi.org/10.1002/14651858.CD006211.pub3

Lewis, SJ, Gardner, M, Higgins, J, Holly, JMP, Gaunt, TR, Perks, CM, Turner, SD, Rinaldi, S, Thomas, S, Harrison, S, Lennon, RJ, Tan, V, Borwick, C, Emmett, P, Jeffreys, M, Northstone, K, Mitrou, G, Wiseman, M, Thompson, R & Martin, RM 2017, 'Developing the WCRF international/University of Bristol methodology for identifying and carrying out systematic reviews of mechanisms of exposure-cancer associations', Cancer Epidemiology, Biomarkers & Prevention, vol. 26, no. 11, pp. 1667-1675. https://doi.org/10.1158/1055-9965.EPI-17-0232

Gaysina, D, Gardner, MP, Richards, M & Ben-Shlomo, Y 2014, 'Cortisol and cognitive function in midlife: the role of childhood cognition and educational attainment', Psychoneuroendocrinology, vol. 47, pp. 189-198. https://doi.org/10.1016/j.psyneuen.2014.05.018

Redaniel, MT, Gardner, MP, Martin, RM & Jeffreys, M 2014, 'The association of vitamin D supplementation with the risk of cancer in postmenopausal women', Cancer Causes & Control, vol. 25, pp. 267-271. https://doi.org/10.1007/s10552-013-0328-4

Halcyon study team 2013, 'Dysregulation of the hypothalamic pituitary adrenal (HPA) axis and physical performance at older ages: an individual participant meta-analysis', Psychoneuroendocrinology, vol. 38, no. 1, pp. 40-9. https://doi.org/10.1016/j.psyneuen.2012.04.016

Stafford, M, Gardner, M, Kumari, M, Kuh, D & Ben-Shlomo, Y 2013, 'Social isolation and diurnal cortisol patterns in an ageing cohort', Psychoneuroendocrinology, vol. 38, no. 11, pp. 2737-45. https://doi.org/10.1016/j.psyneuen.2013.07.002

Halcyon study team 2013, 'Telomere length and physical performance at older ages: an individual participant meta-analysis', PLoS ONE, vol. 8, no. 7, pp. e69526. https://doi.org/10.1371/journal.pone.0069526

Halcyon study team 2011, 'Diurnal cortisol patterns are associated with physical performance in the Caerphilly Prospective Study', International Journal of Epidemiology, vol. 40, no. 6, pp. 1693-702. https://doi.org/10.1093/ije/dyr113

Gardner, MP, Gems, D & Viney, ME 2006, 'Extraordinary plasticity in aging in Strongyloides ratti implies a gene-regulatory mechanism of lifespan evolution', Aging Cell, vol. 5, no. 4, pp. 315-23. https://doi.org/10.1111/j.1474-9726.2006.00226.x

Review article

Stafford, M, Ben-Shlomo, Y, Cooper, C, Gale, C, Gardner, MP, Geoffroy, M-C, Power, C, Kuh, D & Cooper, R 2017, 'Diurnal cortisol and mental well-being in middle and older age: evidence from four cohort studies', BMJ open, vol. 7, no. 10, e016085. https://doi.org/10.1136/bmjopen-2017-016085

Harrison, S, Lennon, R, Holly, J, Higgins, JPT, Gardner, M, Perks, C, Gaunt, T, Tan, V, Borwick, C, Emmet, P, Jeffreys, M, Northstone, K, Rinaldi, S, Thomas, S, Turner, SD, Pease, A, Vilenchick, V, Martin, RM & Lewis, SJ 2017, 'Does milk intake promote prostate cancer initiation or progression via effects on insulin-like growth factors (IGFs)? a systematic review and meta-analysis', Cancer Causes & Control, vol. 28, no. 6, pp. 497-528. https://doi.org/10.1007/s10552-017-0883-1

Halcyon study team, Gardner, M, Bann, D, Wiley, L, Cooper, R, Hardy, R, Nitsch, D, Martin-Ruiz, C, Shiels, P, Sayer, AA, Barbieri, M, Bekaert, S, Bischoff, C, Brooks-Wilson, A, Chen, W, Cooper, C, Christensen, K, De Meyer, T, Deary, I, Der, G, Diez Roux, A, Fitzpatrick, A, Hajat, A, Halaschek-Wiener, J, Harris, S, Hunt, SC, Jagger, C, Jeon, H-S, Kaplan, R, Kimura, M, Lansdorp, P, Li, C, Maeda, T, Mangino, M, Nawrot, TS, Nilsson, P, Nordfjall, K, Paolisso, G, Ren, F, Riabowol, K, Robertson, T, Roos, G, Staessen, JA, Spector, T, Tang, N, Unryn, B, van der Harst, P, Woo, J, Xing, C, Yadegarfar, ME & Park, JY 2014, 'Gender and telomere length: systematic review and meta-analysis', Experimental gerontology, vol. 51, pp. 15-27. https://doi.org/10.1016/j.exger.2013.12.004

Gardner, MP, Adams, A & Jeffreys, M 2013, 'Interventions to increase the uptake of mammography amongst low income women: a systematic review and meta-analysis', PLoS ONE, vol. 8, no. 2, pp. e55574. https://doi.org/10.1371/journal.pone.0055574

View all publications in research portal