Dr Derek Kyte BSc(Hons), MSc, PhD, PCAP, MCSP, MMACP, FHEA

Dr Derek Kyte

Institute of Applied Health Research
Lecturer in Health Research Methods

Contact details

Address
Primary Care & Clinical Sciences
Institute of Applied Health Research
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Derek Kyte, PhD, Lecturer in Health Research Methods at the University of Birmingham UK and NIHR Fellow, has extensive experience in trials methodology, systematic reviews, meta-analysis, and epidemiology. His primary research interests surround health outcomes, including the best-practice use of patient-reported outcome (PRO) assessment in clinical trials and routine practice.

Qualifications

Lecturer in Health Research Methods:

  • PGCert Academic Practice (Merit), University of Birmingham, UK  
  • PhD, University of Birmingham, 2015  
  • MSc in Specialist Manipulative Physiotherapy, University of Birmingham, 2009
  • BSc (Hons) in Physiotherapy, University of Bradford, 1996
  • Member of the Musculoskeletal Association of Chartered Physiotherapy
  • Member of the Chartered Society of Physiotherapy
  • Member of the Health and Care Professionals Council

Biography

Derek completed his undergraduate degree in Physiotherapy at the University of Bradford in 1996. He worked as a Specialist Musculoskeletal Physiotherapist in the NHS for 11 years, before taking up a part-time post as a Clinical Tutor at the University of Birmingham in 2007.   He gained an MSc at the University in 2009 and went on to successfully complete his PhD in 2015. Derek then took up his current post as a HEFCE-funded Lecturer in Health Research Methods in 2015.

Teaching

Postgraduate supervision

PhD Supervision

Birgith Engelst Grove (2018) TelePRO use in the Danish renal population.

Olalekan Ayiegbusi (2015). Using patient reported outcomes to promote quality of care and safety in the management of patients with chronic kidney disease. Funder: Health Foundation.

Samantha Cruz Riviera (2015). Evaluating the impact of patient-reported outcome (PRO) trial results on future patient care. Funder: Mexican Government.

 External advisor: Improving Patient-Reported Outcome research practices and Documentation (The ImPROveD Study) Mercieca-Bebber R, Calvert M, Stockler M, Kyte D, Rutherford C, King M

 Pre-PhD

Nicola Anderson (2017) Using patient reported outcome measures (PROMs) to promote quality of care and safety in the management of patients with established kidney disease requiring treatment with haemodialysis.

 Harjeet Bhachu (2017) Risk communication for renal patients transitioning to RRT.

Research

Research themes

Patient-Reported Outcomes Research, Quality of life measurement in trials, Musculoskeletal Diagnostic Decision-Making, Rehabilitation and Outcome Measurement.

Research Grants and Awards Received (Selected)

Total current grant income in excess of £2.8 million.  In addition, cross-cutting theme contributor for PROs within major NIHR infrastructure (Biomedical Research Centre, Surgical Reconstruction and Microbiology Research Centre, Clinical Research Facility) totalling >further £25million.

  • Anderson N, Kyte D, Dutton M, Cockwell P, Calvert M. (2019-22) Using electronic Patient-ReportedOutcome Measures (ePROMs) to promote quality of care and safety in the management of patients with End Stage Kidney Disease requiring treatment with Haemodialysis (HD) in research and routine clinical settings: a mixed-methods study. NIHR CDRF. Co-I
  • Calvert M, Kyte D et al. Patient-reported outcomes assessment to support accelerated access to advanced cell and gene therapies: PROmics.. Innovate UK. Dec2018 - 30 months. Co-I.
  • Kyte D. Feasibility Study for a Randomised Controlled Trial of electronic Patient-Reported Outcome Measure (ePROM) Use in the Management of Patients with Advanced Chronic Kidney Disease (e-PROM CKD)  NIHR PDF Jan2017-Dec2020. PI
  • Kyte D, Cockwell P, Dutton M, Calvert M The use of an electronic Patient-Reported Outcome Measure (ePROM) in the Management of Dialysis Patients. Kidney Patients Association Oct 2016-Oct 2018, PI
  • Kyte D, Calvert M, Copland C, Armes P, Taylor R, Glaser A, Gavin A, Greenfield D, Brown J, Velikova G. Evaluation of Patient-Reported Outcome (PRO) Protocol Content and Reporting in UK Cancer Clinical Trials – EPiC. Macmillan Cancer Support March 2016-Aug 2018, PI  
  • Calvert M, Kyte D, Draper H, Ives J, Brundage M, CoastJ, Draper H, von Hildebrand M, Ives J, Price G, Roberts L, King M, Mercieca-Bebber R, Blazeby J, Altman D, Brown J, Slade A. Development of the SPIRIT-PRO Extension. Macmillan Cancer Support Jan2017-December 2017, Co-I
  • Calvert M, Kyte D, Ahmed K, Retzer A, Slade A. Increased participation of Black and Minority Ethnic (BME) Groups in primary care clinical trials involving patient-reported outcomes (PROs). West Midlands CRN 2016-17, Co-I
  • Keeley T, Kyte, D, Turner G, Taylor C, Stokes-Lampard H, Calvert M. Exploring he use of PROs in Primary Care  Wellcome Trust Institutional Strategic Support Fund May 2016-Sept 2016, Co-I
  • Gibbons C, Stillwell D, Kyte D, Calvert M, Williams J, Pirzemek L, Cockwel P, Ball S, Ferguson J. Evaluating the implementation of novel computational strategies for the accurate and efficient collection and feedback of patient-reported data in an NHS patient portal.  ESRC Impact Acceleration Account (IAA) Programme 2016-17, Co-I
  • Calvert M, Kyte D, Keeley T, Ahmed K. PROLearn. NIHR CRN Nov 2015-Nov2016, Co-I
  • Calvert M, Kyte D, Keeley T, Ferguson J, Pankhurst T, Kerecuk L. Selection of Patient Reported Outcomes for Rare Disease Metchley park Medical Society Dec 2015-Dec 2016, Co-I
  • Cruz S, Kyte D, Keeley T, Calvert M. Mexican National Council for Science and Technology Impact of PRO trial data on health policy and clinical practice  Oct 2015-Oct 2019, Co-I and second supervisor, Co-I
  • Calvert M, Parry J, Greenfield S, Kyte D, Marshall T, Cockwell P, Gayle N, Litchfield I Health Foundation, Oct 2015-Oct 2019, Co-I
  • Ives J, Draper H, Calvert M, Kyte D. What do potential research participants understand about patient reported outcome measurement and management? An investigation of trial information provision. MRC Midland Hub for Trials Methodology Research 2014-2015, Co-I
  • Calvert M, Kyte D, Draper H, Ives J, Gheorghe A, Brundage M, King M, Mercieca-Bebber R, Blazeby J. Evaluation of patient reported outcomes in clinical trials: systematic review of trial protocols NIHR National School Primary Care Research, 2013-2014, Co-I
  • Kyte D, Calvert M, Draper H, Ives J Methodological and ethical issues in health-related quality of life research NIHR National School Primary Care Research, 2011-2014, PI

Centre for Patient-Reported Outcome Research (CPROR)

Other activities

  • Invited speaker: Symposium: Measuring what matters to HCPs, patients and service providers. National Cancer Research Institute (NCRI) Cancer Conference, Glasgow, November 2018
  • Appointed visiting Associate Professor, Aarhus University, Denmark
  • Appointed Chair: UK National Cancer Research Institute (NCRI) Psychosocial Oncology and Survivorship CSG subgroup: Understanding and measuring the consequences of cancer and its treatment, 2017.
  • Appointed Advisor: NHS England/Macmillan Cancer Support Cancer Dashboard Quality of Life Metric Project, 2017
  • Conference organiser steering group: UK National PROMs Conference 2018, University of Birmingham, UK
  • Invited workshop co-lead: International Society for Quality of Life Research Annual Conference Improving the Design of Clinical Trials with PROs: Tips for Protocol Design and Review, Berlin 2014, Vancouver 2015, Copenhagen 2016, Philadelphia 2017.
  • Invited speaker: The use of electronic patient-reported outcomes (ePROMs) in routine renal care. Fresenius Medical Care AG & Co., Bad Homburg,
  • Germany, 2017
  • Invited speaker: The use of electronic patient-reported outcomes (ePROMs) in routine clinical care. The Patient Voice in Ophthalmic Research workshop, Wednesday 12th July, 2017, University of Birmingham, UK.
  • Invited speaker: The use of electronic patient-reported outcomes (ePROMs) in routine renal care. LCRN Renal Speciality Meeting, University of Birmingham, UK, 2017
  • Research incorporated into European Medicine Agency guidelines on the evaluation of anticancer medicinal products in man and in the prestigious PLOS Progress update 2014/2015, an annual summary of innovations, activities and journal highlights. 
  • Invited member of the International Society of Quality of Life Research Taskforce: leading the response to the European Medicines Agency Reflection Paper on the use of patient reported outcome (PRO) measures in oncology studies. Submitted to the EMA – report available on the ISOQOL website with paper published in Quality of Life Research (lead author), 2016.
  • Invited speaker: Systematic evaluation of patient-reported outcome (PRO) protocol content and reporting in UK cancer clinical trials: the EPiC study. British Psychosocial Oncology Society Annual Conference 16th & 17th March 2017, Oxford, UK.
  • Invited speaker: Introduction to Patient Reported Outcomes in Primary Care. SW-SAPC, Birmingham, 2015.
  • Invited Symposium: International Society for Quality of Life Research 21st Annual Conference Monitoring Patient Reported Outcome Alerts in Clinical Trials and Routine Practice: An Expert Panel Discussion of Current Knowledge and Priority Areas for Research, Berlin October 2014.
  • Invited member of the International Society of Quality of Life Research Taskforce: Best Practices for PROs in Randomised Clinical Trials. Dr Kyte is a member of the executive operations group leading development of the SPIRIT-PRO Extension, 2014.
  • Invited speaker: 4th NIHR Experimental Medicine Research Training Camp. NIHR SPCR Trainees' Annual Event, Oxford 2013.
  • Peer reviewer: UK Patient-Reported Outcomes Conference, Oxford, 2017; NIHR Research for Patient Benefit (RfPB) program; MRC Methodology Research Programme; Yorkshire Cancer Research; British Journal of Cancer; Contemporary Clinical Trials Journal; Quality of Life Research Journal; Digital Health Journal; Research Involvement and Engagement

Publications

RESEARCH PUBLICATIONS

H-index = 13; total publications = 44; total citations = 485. (* indicates role as corresponding author)

Kyte, D*, Retzer, A., Keeley, T., Ahmed, K., Armes, J., Brown, J. M., Calman, L., Copland, C., Efficace, F., Gavin, A., Glaser, A., Greenfield, D. M., Lanceley, A., Taylor, R. M., Velikova, G., Brundage, M., Mercieca-Bebber, R., King, M. T., Calvert, M. (in press) Systematic evaluation of Patient-Reported Outcome protocol content and reporting in cancer trials. JNCI.

Anderson N, Calvert M, Cockwell P, Dutton M, Kyte D. (in press) The use of Patient-Reported Outcome Measures (PROMs) in patients with End Stage Renal Disease requiring treatment with Haemodialysis: A Narrative Review. American Journal of Kidney Diseases.

Calvert M, Kyte D, Price G, Valderas JM, Hjollund NH. Maximising the impact of patient reported outcome assessment for patients and society. BMJ  2019;  364 :k5267

Turner G, Slade A, Retzer A, McMullan C, Kyte D, Belli A, Calvert M. (in press) Patient Reported Outcomes Research in Trauma: The PRiORiTy study qualitative protocol. BMJ Open.

Kaur G, Kyte D, Basch E, Reeve B, Calvert M. Patient-reported outcome monitoring in a routine paediatric oncology setting: challenges and opportunities. Lancet Oncology. The Lancet Oncology, Volume 20, Issue 1, 2019, Pages 19-20, https://doi.org/10.1016/S1470-2045(18)30785-X.

Turner G, Slade A, Retzer A, McMullan C, Kyte D, Belli A, Calvert M. (in press) An Introduction to Patient Reported Outcome Measures (PROMs) in Trauma. The Journal of Trauma and Acute Care Surgery.

Anderson N, Calvert M, Cockwell P, Dutton M, Kyte D. (in press) Using patient reported outcome measures (PROMs) to promote quality of care and safety in the management of patients with established kidney disease requiring treatment with haemodialysis (PROM-HD) – A qualitative study protocol. BMJ Open.

Aiyegbusi OL, Kyte D, Cockwell P, Marshall T, Dutton M, Walmsley-Allen N, Auti R, Calvert M (in press) Development and usability testing of an electronic patient-reported outcome measure (ePROM) system for patients with advanced chronic kidney disease. Computers in Biology and Medicine.

Isa F, Turner GM, Kaur G, Kyte D*, Slade a, Pankhurst T, Kerecuk, Keeley T, Ferguson J, Calvert M. (in press) Patient-reported outcome measures in patients with primary sclerosing cholangitis: a systematic review. Health and Quality of Life Outcomes. 2018. 

Retzer A, Kyte D, Stephens R, Glaser A, Calman L, Calvert M. The importance of patient-reported outcomes in cancer studies. (in press) Expert Review of Quality of Life in Cancer Care. 2018. 

Slade A, Isa F, Kyte D*, et al. Patient reported outcome measures in rare diseases: a narrative review. Orphanet J Rare Dis 2018;13(1):61 

Calvert M, Kyte D, Mercieca-Bebber R, Slade A, Chan AW, King MT, et al. Guidelines for Inclusion of Patient-Reported Outcomes in Clinical Trial Protocols: The SPIRIT-PRO Extension. JAMA. 2018;319(5):483-94.

Retzer, A., Keeley, T., Ahmed, K., Armes, J., Brown, J. M., Calman, L., Copland, C., Efficace, F., Gavin, A., Glaser, A., Greenfield, D. M., Lanceley, A., Taylor, R. M., Velikova, G., Brundage, M., Mercieca-Bebber, R., King, M. T., Calvert, M. & Kyte, D*. 2018. Evaluation of patient-reported outcome protocol content and reporting in UK cancer clinical trials: The EPiC study qualitative protocol. BMJ Open, 8, e017282.

Chauhan, A., De Wildt, G., Virmond, M., Kyte, D., Galan, N. G. A., Prado, R. B. R. & Shyam-Sundar, V. 2018. Perceptions and experiences regarding the impact of race on the quality of healthcare in Southeast Brazil: a qualitative study. Ethn Health, 1-17.

Williams FR, Vallance A, Faulkner T, Towey J, Kyte D, Durman S, Johnson J, Holt A, Perera T, Ferguson J and Armstrong MJ Home-based exercise therapy in patients awaiting liver transplantation: Protocol for an observational feasibility trial. BMJ Open. 2018 Jan 21;8(1):e019298. doi: 10.1136/bmjopen-2017-019298.

Mercieca-Bebber R, Calvert M, Kyte D, Stockler M, King MT. The administration of patient-reported outcome questionnaires in cancer trials: interviews with trial coordinators regarding their roles, experiences, challenges and training. Contemporary Clinical Trials Communications, 2017. 2017 Nov 23;9:23-32. doi: 10.1016/j.conctc.2017.11.009

Aiyegbusi OL, Kyte D*, Cockwell P, et al. A patient-centred approach to measuring quality in kidney care: patient-reported outcome measures and patient-reported experience measures. Curr Opin Nephrol Hypertens2017;26(6):442-49. doi: 10.1097/mnh.0000000000000357 PMID: 28806191 

Cruz Rivera S, Kyte D*, Aiyegbusi OL, et al. Assessing the impact of healthcare research: A systematic review of methodological frameworks. PLoS Med 2017;14(8):e1002370. doi: 10.1371/journal.pmed.1002370 PMID: 28792957

Aiyegbusi OL, Kyte D*, Cockwell P, et al. Using Patient-Reported Outcome Measures (PROMs) to promote quality of care and safety in the management of patients with Advanced Chronic Kidney disease (PRO-trACK project): a mixed-methods project protocol. BMJ Open 2017;7(6):e016687. doi: 10.1136/bmjopen-2017-016687 PMID: 28667225

Aiyegbusi OL, Kyte D*, Cockwell P, et al. Measurement properties of patient-reported outcome measures (PROMs) used in adult patients with chronic kidney disease: A systematic review. PLoS One 2017;12(6):e0179733.  doi: 10.1371/journal.pone.0179733 PMID:28636678

Dean S, Mathers JM, Calvert M, Kyte D, Conroy D, Folkard A, et al. "The patient is speaking": discovering the patient voice in ophthalmology. Br J Ophthalmol 2017;101(6):700-08. doi: 10.1136/bjophthalmol-2016-309955 PMID: 28455280

Kyte D, Cockwell P, Lencioni M, et al. Reflections on the national patient-reported outcome measures (PROMs) programme: Where do we go from here? Journal of the Royal Society of Medicine 2016;109(12):441-45. doi: 10.1177/0141076816677856 PMID: 27923896 

Jesky M, Dutton M, Dasgupta I, Yadav P, Ng K, Fenton A, Kyte D, Ferro C, Calvert M, Cockwell P and Stringer S. Health-Related Quality of Life Impacts Mortality but Not Progression to End-Stage Renal Disease in Pre-Dialysis Chronic Kidney Disease: A Prospective Observational Study. PLoS One 2016;11(11):e0165675. doi: 10.1371/journal.pone.0165675 PMID: 27832126 

Aiyegbusi OL, Kyte D*, Cockwell P, et al. Measurement properties of patient-reported outcome measures (PROMs) used in adult patients with chronic kidney disease: a systematic review protocol. BMJ Open2016;6(10):e012014. doi: 10.1136/bmjopen-2016-012014 PMID: 27733411

Kyte D*, Ives J, Draper H, et al. Current practices in patient-reported outcome (PRO) data collection in clinical trials: a cross-sectional survey of UK trial staff and management. BMJ Open 2016;6(10):e012281. doi: 10.1136/bmjopen-2016-012281 PMID: 27697875

Ahmed K, Kyte D*, Keeley T, et al. Systematic evaluation of patient-reported outcome (PRO) protocol content and reporting in UK cancer clinical trials: the EPiC study protocol. BMJ Open 2016;6(9):e012863. doi: 10.1136/bmjopen-2016-012863 PMID: 27655263 

Mercieca-Bebber R, Friedlander M, Kok P, Calvert M, Kyte D, Stockler M and King, MT. The patient-reported outcome content of international ovarian cancer randomised controlled trial protocols. Qual Life Res2016;25(10):2457-65. doi: 10.1007/s11136-016-1339-x PMID: 27294435

Kyte D*, Ives J, Draper H, et al. Management of Patient-Reported Outcome (PRO) Alerts in Clinical Trials: A Cross Sectional Survey. PLoS One 2016;11(1):e0144658. doi: 10.1371/journal.pone.0144658 PMID: 26785084

Kyte D*, Reeve BB, Efficace F, et al. International Society for Quality of Life Research commentary on the draft European Medicines Agency reflection paper on the use of patient-reported outcome (PRO) measures in oncology studies. Qual Life Res 2016;25(2):359-62. doi: 10.1007/s11136-015-1099-z PMID: 26275979

Calvert M, Thwaites R, Kyte D, et al. Putting patient-reported outcomes on the 'Big Data Road Map'. Journal of the Royal Society of Medicine 2015;108(8):299-303. doi: 10.1177/0141076815579896 PMID: 25827908

Calvert M, Kyte D, von Hildebrand M, et al. Putting patients at the heart of health-care research. Lancet 2015;385(9973):1073-4. doi: 10.1016/s0140-6736(15)60599-2 PMID: 25797557

Kyte D*, Calvert M, van der Wees PJ, et al. An introduction to patient-reported outcome measures (PROMs) in physiotherapy. Physiotherapy 2015;101(2):119-25. doi: 10.1016/j.physio.2014.11.003 PMID: 25620440

Green A, Liles C, Rushton A, Kyte D*. Reply to Selfe (2014) letter to the editor on: measurement properties of patient-reported outcome measures (PROMS) in patellofemoral pain syndrome: a systematic review. Manual therapy 2015;20(2):e7. doi: 10.1016/j.math.2014.10.018 PMID: 25487345

Calvert M, Kyte D*, Duffy H, et al. Patient-reported outcome (PRO) assessment in clinical trials: a systematic review of guidance for trial protocol writers. PLoS One 2014;9(10):e110216. doi: 10.1371/journal.pone.0110216 PMID: 25333995

Kyte D*, Duffy H, Fletcher B, et al. Systematic evaluation of the patient-reported outcome (PRO) content of clinical trial protocols. PLoS One 2014;9(10):e110229. doi: 10.1371/journal.pone.0110229 PMID: 25333349

Green A, Liles C, Rushton A, Kyte D*. Measurement properties of patient-reported outcome measures (PROMS) in Patellofemoral Pain Syndrome: a systematic review. Manual therapy 2014;19(6):517-26. doi: 10.1016/j.math.2014.05.013 PMID: 24997774 

Freemantle N, Shallcross LJ, Kyte D, et al. Oseltamivir: the real-world data. BMJ 2014;348:g2371. doi: 10.1136/bmj.g2371 PMID: 24811409

Denniston AK, Kyte D, Calvert M, et al. An introduction to patient-reported outcome measures in ophthalmic research. Eye (London, England) 2014;28(6):637-45. doi: 10.1038/eye.2014.41 PMID: 24625379

Gheorghe A, Kyte D, Calvert M. The need for increased harmonisation of clinical trials and economic evaluations. Expert Rev Pharmacoecon Outcomes Res 2014;14(2):171-3. doi: 10.1586/14737167.2014.894461 PMID: 24597464

Calvert M, Draper H, Kyte D*. Patient-reported outcome alert monitoring--reply. JAMA 2014;311(4):420-1. doi: 10.1001/jama.2013.284330 PMID: 24449327 

Kyte D*, Ives J, Draper H, et al. Inconsistencies in quality of life data collection in clinical trials: a potential source of bias? Interviews with research nurses and trialists. PLoS One 2013;8(10):e76625. doi: 10.1371/journal.pone.0076625 PMID: 24124580

Kyte D*, Draper H, Calvert M. Patient-reported outcome alerts: ethical and logistical considerations in clinical trials. JAMA 2013;310(12):1229-30. doi: 10.1001/jama.2013.277222 PMID: 24065005 doi: 10.1001/jama.2013.277222 PMID: 24065005 

Kyte D*, Draper H, Ives J, et al. Patient reported outcomes (PROs) in clinical trials: is 'in-trial' guidance lacking? a systematic review. PLoS One 2013;8(4):e60684. doi: 10.1371/journal.pone.0060684 PMID: 23560103 

Kyte D*, Rushton A, Eveleigh G. Factors affecting myofascial pain pattern recognition in musculoskeletal therapists: an exploratory study. International Journal of Therapy & Rehabilitation. 2012 Mar 1;19(3). 

Other publications

Kyte D, Calvert M (2014) Patient-reported outcomes: the heart of healthcare research? The Birmingham Brief. (link)

Calvert M, Kyte D. (2013) Institute of Advanced Studies Workshop Report: Best Practices for Patient Reported Outcomes (PROs) in Randomised Clinical Trials.http://www.birmingham.ac.uk/research/activity/mds/domains/health-pop/healthcare-evaluation-and-methodology/patient-reported-outcomes/index.aspx