PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection. C M Buckley, V L Heath, A Guelho, SK Dove, R H Michell, R Meier, H Hilbi, T Soldati, R H Insall & J S King (2018) PLOS Pathogens, 15: e1007551. doi: 10.1371/journal.ppat.1007551.
Do inositol supplements enhance phosphatidylinositol supply and thus support endoplasmic reticulum function? R H Michell (2018) British Journal of Nutrition 120, 301-316.
The gradual recognition that inositol lipids do many things for eukaryotic cells. R H Michell (2016) Messenger, 5, 3-23.
Drug redeployment to kill leukaemia and lymphoma kills cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids. A D Southam, F L Khanim, RE Hayden, J K Constantinou, K M Koczula, R H Michell, M R Viant, M T Drayson & C M Bunce (2015) Cancer Research 75, 2530-2540.
Inositol lipids – from an Archaeal origin to phosphatidylinositol 3,5-bisphosphate faults in human disease. R H Michell (2013) FEBS Journal, 280,6281-6294.
Phosphatidylinositol 3,5-bisphosphate and Fab1p/ PIKfyve underPPIn endo-lysosome function. S K Dove, K Dong, T Kobayashi, F K Williams & R H Michell (2009) Biochemical Journal 419, 1-13
Inositol derivatives: evolution and functions. R H Michell (2008) Nature Reviews in Molecular Cell Biology 9, 151-161.
Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions. R H Michell, V Heath, M Lemmon & S K Dove (2006) Trends in Biochemical Sciences 31, 52-63 (plus online material)
Earlier historically significant contributions
Osmotic stress activates phosphatidylinositol 3,5-trisphosphate synthesis. S K Dove, F Cooke, M R Douglas, P Parker & R H Michell (1997) Nature, 390, 187-192.
Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilising hormones. J A Creba, C P Downes, P T Hawkins, G Brewster, R H Michell & C J Kirk (1983) Biochem. J. 212, 733-747.
The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions. R H Michell, C J Kirk, L M Jones, C P Downes & J A Creba (1981) Philosophical. Transaction of the Royal Society of London. Series B. 296, 123-133.
Inositol phospholipids and cell surface receptor function. R H Michell
(1975) Biochimica et Biophysica Acta, 415, 81-147.
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