Dr Rachel Bayley BSc, PhD

Institute of Cancer and Genomic Sciences
Research Fellow

Contact details

Institute of Cancer and Genomic Sciences
Room WX1.67, IBR West
College of Medical and Dental Sciences
University of Birmingham
Birmingham B15 2TT

Dr Rachel Bayley is a Research Fellow working in the group of Dr Martin Higgs in the Institute of Cancer and Genomic Sciences. Her main area of expertise is DNA double-strand break repair and how deregulation of this can lead to the development of human diseases. She also has a particular interest in DNA double-strand break repair mechanisms in stem cells of the haematopoietic system.


  • PhD in Immunology, University of Birmingham 2014
  • BSc in Biomedical Science (1st Class Hons), University of Birmingham 2010


Rachel Bayley received her BSc in Biomedical Science from the University of Birmingham in 2010 and continued at this institution to complete her PhD training in the fields of immunology and cell signalling. She went on to carry out post-doctoral training at Loughborough University where she gained an interest in stem cells, haematopoiesis and regenerative medicine. Most recently, Rachel has returned to the University of Birmingham to complete further post-doctoral training in the laboratories of Dr Paloma Garcia and Dr Martin Higgs to work on mechanisms of DNA double-strand break repair, with a particular focus on the roles of lysine methylation in this process.


The role of protein methylation in DNA double-strand break repair in the development of diseases relating to the haematopoietic system. Study of how DNA damage impacts on the differentiation and function of haematopoietic stem cells.   


MYBL2 mRNA expression as a potential biomarker of therapeutic response to genotoxic treatments in myelodysplastic syndrome. Bayley R, Blakemore D, García P, Oncotarget, 2018, Vol. 9, (No. 101), pp: 37460-37461

On your marks, get SET(D1A): the race to protect stalled replication forks. Begum S, GoulaA, Bayley R, HiggsMR, Molecular and Cellular Oncology, 2018, doi:10.1080/23723556.2018.1511209

MYBL2 supports DNA double strand break repair in haematopoietic stem cells. Bayley R, Blakemore D, Cancian L, Dumon S, Volpe G, Ward C, Almaghrabi R, Gujar J, Reeve N, Raghavan M, Higgs MR, Stewart GS, Petermann E, García P, Cancer Research, 2018, doi: 10.1158/0008-5472.CAN-18-0273. [Epub ahead of print]

Histone methylation by SETD1A protects nascent DNA through the nucleosome chaperone activity of FANCD2. HiggsMR, Sato K, Reynolds JJ, Begum S, Bayley R, GoulaA, Vernet A, Paquin KL, Skalnik DG, Kobayashi W, Takata M, Howlett NG, Kurumizaka H, Kimura H, StewartGS, Molecular Cell, 2018, 71(1): 25-41 

DNA repair mechanisms in stem cells and their implications during ageing. Bayley R and García P, Textbook Chapter in DNA Repair and Replication: Mechanisms and Clinical Significance, 2018, Chapter 14 

The productivity limit of manufacturing blood cell therapy in scalable stirred bioreactors. Bayley R, Ahmed F, Glen K, McCall M, Stacey A, Thomas R, Journal of Tissue Engineering and Regenerative Medicine, 2017, 10.1002/term.2337 

The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in rheumatoid arthritis patients and healthy controls. Bayley R, Kite KA, McGettrick HM, Smith JP, Kitas GD, Buckley CD, Young SP, Annals of the Rheumatic Diseases, 2015, Aug; 74(8):1588-95 

Measuring the activity of the protein tyrosine phosphatase Lyp. Bayley R, Yang P, Buckley CD, Young SP, Journal of Immunological Methods, 2013, 388: 1-2, p33-39

Does Oxidative Inactivation of CD45 Phosphatase in Rheumatoid Arthritis Underlie Immune Hyporesponsiveness? Rider DA, Bayley R, Clay E, Young SP, Antioxidants and Redox Signalling, 2013, 19(18):2280-5 

Differential Expression of CD148 on leucocyte subsets in inflammatory arthritis. Richa D, Naylor A, Young SP, Bayley R, Hardie D, Haworth O, Rider DA, Cook A, Buckley CD, Kellie S, Arthritis Research and Therapy, 2013, 15:R108 

Early rheumatoid arthritis and resolving fibroblasts segregate according to Dickkopf related protein 1 expression. Juarez M, Scheel Toellner D, Karouzakis E, Hardy R, Yeo L, Bayley R, de Paz B, Raza K, Cooper M, Gay S, Buckley CD, Filer A, The Lancet, 2013, p57 

Metabolomics in the analysis of inflammatory diseases. Kapoor S, Fitzpatrick M, Clay E, Bayley R, Wallace GR, Young SP, Textbook chapter in Metabolomics, 2012, Chapter 11; pages 269-288                                                                                                          

View all publications in research portal