Andrew D Beggs FRCS (Gen), PhD

Andrew D Beggs

Institute of Cancer and Genomic Sciences
Head of Section - Molecular Oncology, Pathology and Genetics, Reader in Surgery & Cancer Genetics
Head of West Midlands GI & Gynaecology Cancer Tumour Board
Cancer Research UK & RCSEng Advanced Clinician Scientist, Consultant Colorectal & General Surgeon

Contact details

Address
Institute of Cancer and Genomic Sciences
University of Birmingham
Vincent Drive
Birmingham
B15 2TT
UK

Andrew Beggs is a Reader in Cancer Genetics & Surgery in the Institute of Cancer and Genomic Sciences, University of Birmingham. He currently holds a Cancer Research UK & Royal College of Surgeons Advanced Clinician Scientist award. He is also an Consultant Colorectal & General  Surgeon at the Queen Elizabeth Hospital in Birmingham with a subspeciality interest in laparoscopic rectal cancer surgery and advanced endoscopy.

His major research interests include colorectal, oesophageal and sarcoma cancer biology and translational medicine. He has published articles in The Lancet, Gut, Journal of Pathology and PLoS Genetics. He collaborated in writing the European consensus guidelines for the management of Peutz-Jeghers syndrome.

Andrew has been awarded grant funding from Cancer Research UK, Medical Research Council, Wellcome Trust, Illumina UK, Cancer Research UK, Mason Medical Research Foundation, Peel Medical Research Trust & St Georges Hospital Charity.

His current research programme is examining the molecular genetics of colorectal cancer, and has recently received programme funding from CRUK to set up organoid model systems to understand neoadjuvant chemoradiosensitivity in rectal cancer.  He is also carrying out research into rare cancers using multi-omics profiling;  biomarker development technologies and runs a bioinformatics “dry-lab” to search for novel therapeutic targets and stratification markers.

For more information please look at the laboratory website .

We face two key factors when trying to save patients' lives; early diagnosis and matching the right drug to the individual patient. With help, Birmingham could develop a genetic test, to catch the early signs of bowel cancer before the patient themselves becomes aware of them. Find out how to support our research through the Birmingham in Action campaign.

Qualifications

  • FRCS(Gen) – subspecialty training in Coloproctology 2016
  • PhD Cancer Genetics, 2012
  • MRCS (England), 2006
  • MBBS with distinction Medicine & Surgery, 2003
  • BSc(Hons) Radiological Sciences (i), 2000

Teaching

Postgraduate supervision

Cancer Genetics, Surgery

Research

Cancer Genetics, Epigenetics, Next generation sequencing, microarrays

Colorectal Cancer

Oesophagogastric cancer

Sarcoma

 

Other activities

  • GMC Partner:  Andrew works for the General Medical Council appraising specialist and foundation training in surgery as well as curriculum approvals for surgical specialties
  • Deputy Chair of Junior Investigators Group, CRUK Experimental Cancer Medicine Centre Network 2012-2015
  • Scientific Director, College of Medical and Dental Sciences Genomics Facility (Genomics Birmingham)
  • Andrew is currently a reviewer for The Lancet, British Medical Journal, The Journal of Neurological Sciences, British Journal of Surgery, Genes Chromosomes & Cancers, Gastroenterology and PLoS ONE. He also acts as a peer reviewer for Cancer Research UK, the MRC, The CORE Charity, Big-C Cancer Research and Heart UK.
  • University enabling technologies committee GeCIP for 100KG colorectal

Publications

Recent publications

Article

Kleeman, SO, Koelzer, VH, Jones, HJ, Vazquez, EG, Davis, H, East, JE, Arnold, R, Koppens, MA, Blake, A, Domingo, E, Cunningham, C, Beggs, AD, Pestinger, V, Loughrey, MB, Wang, L-M, Lannagan, TR, Woods, SL, Worthley, D, Consortium, SC, Tomlinson, I, Dunne, PD, Maughan, T & Leedham, SJ 2019, 'Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification', Gut. https://doi.org/10.1136/gutjnl-2019-319126

Brooks, J, Antao Mobre De Menezes, ARE, Ibrahim, M, Archer, L, Lal, N, Bagnall, C, Zeidler, SVV, Valentine, H, Spruce, R, Batis, N, Bryant, J, Hartley, M, Kaul, B, Ryan, G, Bao, R, Khattri, A, Lee, S, Ogbureke, KUE, Middleton, G, Tennant, D, Beggs, A, Deeks, J, West, CML, Cazier, J-B, Willcox, B, Seiwert, TY & Mehanna, H 2019, 'Development and validation of a combined hypoxia and immune prognostic classifier for head and neck cancer: hypoxia-immune prognostic classifier for HNC', Clinical Cancer Research, vol. 25, no. 17, pp. 5315-5328. https://doi.org/10.1158/1078-0432.CCR-18-3314

MacKie, F, Baker, B, Beggs, A, Stodolna, A, Morris, RK & Kilby, M 2019, 'MicroRNA changes in maternal serum from pregnancies complicated by twin-twin transfusion syndrome: a discovery study', Prenatal Diagnosis, vol. 39, no. 8, pp. 616-634. https://doi.org/10.1002/pd.5475

Hallam, S, Tyler, R, Price, M, Beggs, A & Youssef, H 2019, 'Meta-analysis of prognostic factors for patients with colorectal peritoneal metastasis undergoing cytoreductive surgery and heated intraperitoneal chemotherapy: Prognostic factors in colorectal peritoneal metastasis', BJGP Open. https://doi.org/10.1002/bjs5.50179

Thomas, PR, Beggs, AD & Han, TS 2019, 'Utility of surgeon-performed pre-operative ultrasound in the localisation of parathyroid adenomas', JRSM cardiovascular disease, vol. 8. https://doi.org/10.1177/2048004019856949

Ward, D, Gordon, N, Boucher, R, Pirrie, S, Baxter, L, Ott, S, Silcock, L, Whalley, C, Stockton, J, Beggs, A, Griffiths, M, Abbotts, B, Ijakipour, H, Latheef, F, Robinson, R, White, A, James, N, Zeegers, M, Cheng, KK & Bryan, R 2019, 'Targeted deep sequencing of urothelial bladder cancers and associated urinary DNA: a 23-gene panel with utility for non-invasive diagnosis and risk stratification', BJU international. https://doi.org/10.1111/bju.14808

Horniblow, R, Mistry, P, Quraishi, MN, Beggs, A, van De Weile, T, Iqbal, T & Tselepis, C 2019, 'The safety and tolerability of a potential alginate-based iron chelator: results of a healthy participant study', Nutrients, vol. 11, no. 3, 674. https://doi.org/10.3390/nu11030674

Dilworth, MP, Nieto, T, Stockton, JD, Whalley, CM, Tee, L, James, JD, Noble, F, Underwood, TJ, Hallissey, MT, Hejmadi, R, Trudgill, N, Tucker, O & Beggs, AD 2019, 'Whole genome methylation analysis of nondysplastic Barrett esophagus that progresses to invasive cancer', Annals of surgery, vol. 269, no. 3, pp. 479–485. https://doi.org/10.1097/SLA.0000000000002658

Beggs, A, Mehta, S, Deeks, J, James, JD, Caldwell, G, Dilworth, M, Stockton, J, Blakeway, D, Pestinger, V, Vince, A, Taniere, P, Iqbal, T, Magill, L, Matthews, G & Morton, D 2019, 'Validation of epigenetic markers to identify colitis associated cancer: Results of module 1 of the ENDCAP-C study', EBioMedicine, vol. 39, pp. 265-271. https://doi.org/10.1016/j.ebiom.2018.11.034

Assi, SA, Imperato, MR, Coleman, DJL, Pickin, A, Potluri, S, Ptasinska, A, Chin, PS, Blair, H, Cauchy, P, James, SR, Zacarias-cabeza, J, Gilding, LN, Beggs, A, Clokie, S, Loke, JC, Jenkin, P, Uddin, A, Delwel, R, Richards, SJ, Raghavan, M, Griffiths, MJ, Heidenreich, O, Cockerill, PN & Bonifer, C 2018, 'Subtype-specific regulatory network rewiring in acute myeloid leukemia', Nature Genetics, vol. 51, no. 1, pp. 151-162. https://doi.org/10.1038/s41588-018-0270-1

Pentland, I, Campos Leon, K, Cotic, M, Davies, K-J, Wood, CD, Groves, I, Burley, M, Coleman, N, Stockton, J, Noyvert, B, Beggs, A, West, M, Roberts, S & Parish, J 2018, 'Disruption of CTCF-YY1 dependent looping of the human papillomavirus genome activates differentiation-induced viral oncogene transcription', PLoS Biology, vol. 16, no. 10, e2005752. https://doi.org/10.1371/journal.pbio.2005752

Payne, K, Spruce, R, Beggs, A, Sharma, N, Kong, A, Martin, T, Parmar, S, Praveen, P, Nankivell, P & Mehanna, H 2018, 'Circulating tumor DNA as a biomarker and liquid biopsy in head and neck squamous cell carcinoma', Head & Neck, vol. 40, no. 7, pp. 1598-1604. https://doi.org/10.1002/hed.25140

Abstract

Mehanna, HM, Brooks, J, Menezes, A, Ibrahim, M, Lal, N, Archer, L, Zeidler, SV, Bao, R, Khattri, A, Valentine, H, Spruce, R, Batis, N, Bryant, J, Beggs, AD, Tennant, D, West, C, Middleton, GW, Cazier, J-B, Willcox, B & Seiwert, TY 2018, 'Development and validation of a combined metabolic and immune prognostic classifier for head and neck cancer', Journal of Clinical Oncology, vol. 36, no. 15 Suppl, pp. 6049-6049. https://doi.org/10.1200/jco.2018.36.15_suppl.6049

Patent

Tucker, J, Pikramenou, Z, Beggs, A, Nagy, Z & Chakrabarti, P Aug. 09 2018, Sensor WO2019043353A1: WO2019043353A1, Patent No. WO2019043353A1, IPC No. WO2019043353A1.

Review article

Sillo, TO, Beggs, AD, Morton, DG & Middleton, G 2019, 'Mechanisms of immunogenicity in colorectal cancer', British Journal of Surgery. https://doi.org/10.1002/bjs.11204

View all publications in research portal