Professor Andrew Beggs FRCS (Gen), PhD

Professor Andrew Beggs

Institute of Cancer and Genomic Sciences
Head of Section - Molecular Oncology, Pathology and Genetics, Professor in Surgery & Cancer Genetics
Head of West Midlands GI & Gynaecology Cancer Tumour Board
Cancer Research UK & RCSEng Advanced Clinician Scientist, Consultant Colorectal & General Surgeon

Contact details

Address
Institute of Cancer and Genomic Sciences
University of Birmingham
Vincent Drive
Birmingham
B15 2TT
UK

Andrew Beggs is a Professor of Cancer Genetics & Surgery in the Institute of Cancer and Genomic Sciences, University of Birmingham. He currently holds a Cancer Research UK & Royal College of Surgeons Advanced Clinician Scientist award. He is also an Consultant Colorectal & General  Surgeon at the Queen Elizabeth Hospital in Birmingham with a subspeciality interest in laparoscopic rectal cancer surgery and advanced endoscopy.

His major research interests include colorectal, oesophageal and sarcoma cancer biology and translational medicine. He has published articles in The Lancet, Gut, Journal of Pathology and PLoS Genetics. He collaborated in writing the European consensus guidelines for the management of Peutz-Jeghers syndrome.

Andrew has been awarded grant funding from Cancer Research UK, Medical Research Council, Wellcome Trust, Illumina UK, Cancer Research UK, Mason Medical Research Foundation, Peel Medical Research Trust & St Georges Hospital Charity.

His current research programme is examining the molecular genetics of colorectal cancer, and has recently received programme funding from CRUK to set up organoid model systems to understand neoadjuvant chemoradiosensitivity in rectal cancer.  He is also carrying out research into rare cancers using multi-omics profiling;  biomarker development technologies and runs a bioinformatics “dry-lab” to search for novel therapeutic targets and stratification markers.

For more information please look at the laboratory website .

We face two key factors when trying to save patients' lives; early diagnosis and matching the right drug to the individual patient. With help, Birmingham could develop a genetic test, to catch the early signs of bowel cancer before the patient themselves becomes aware of them. Find out how to support our research through the Birmingham in Action campaign.

Qualifications

  • FRCS(Gen) – subspecialty training in Coloproctology 2016
  • PhD Cancer Genetics, 2012
  • MRCS (England), 2006
  • MBBS with distinction Medicine & Surgery, 2003
  • BSc(Hons) Radiological Sciences (i), 2000

Teaching

Postgraduate supervision

Cancer Genetics, Surgery

Research

Cancer Genetics, Epigenetics, Next generation sequencing, microarrays

Colorectal Cancer

Oesophagogastric cancer

Sarcoma

 

Other activities

  • GMC Partner:  Andrew works for the General Medical Council appraising specialist and foundation training in surgery as well as curriculum approvals for surgical specialties
  • Deputy Chair of Junior Investigators Group, CRUK Experimental Cancer Medicine Centre Network 2012-2015
  • Scientific Director, College of Medical and Dental Sciences Genomics Facility (Genomics Birmingham)
  • Andrew is currently a reviewer for The Lancet, British Medical Journal, The Journal of Neurological Sciences, British Journal of Surgery, Genes Chromosomes & Cancers, Gastroenterology and PLoS ONE. He also acts as a peer reviewer for Cancer Research UK, the MRC, The CORE Charity, Big-C Cancer Research and Heart UK.
  • University enabling technologies committee GeCIP for 100KG colorectal

Publications

Recent publications

Article

Breeze, J, Bowley, DM, Combes, JG, Baden, J, Orr, L, Beggs, A, DuBose, J & Powers, DB 2020, 'Outcomes following penetrating neck injury during the Iraq and Afghanistan conflicts: A comparison of treatment at US and United Kingdom medical treatment facilities', The Journal of Trauma and Acute Care Surgery, vol. 88, no. 5, pp. 696-703. https://doi.org/10.1097/TA.0000000000002625

Pestinger, V, Smith, M, Sillo, T, Findlay, JM, Laes, J-F, Martin, G, Middleton, G, Taniere, P & Beggs, AD 2020, 'Use of an integrated pan-cancer oncology enrichment next-generation sequencing assay to measure tumour mutational burden and detect clinically actionable variants', Molecular Diagnosis and Therapy. https://doi.org/10.1007/s40291-020-00462-x

Schwenzer, H, Abdel Mouti, M, Neubert, P, Morris, J, Stockton, J, Bonham, S, Fellermeyer, M, Chettle, J, Fischer, R, Beggs, AD & Blagden, SP 2020, 'LARP1 isoform expression in human cancer cell lines', RNA biology. https://doi.org/10.1080/15476286.2020.1744320

Breeze, J, Bowley, DM, Harrisson, SE, Dye, J, Neal, C, Bell, RS, Armonda, RA, Beggs, AD, DuBose, J, Rickard, RF & Powers, DB 2020, 'Survival after traumatic brain injury improves with deployment of neurosurgeons: a comparison of US and UK military treatment facilities during the Iraq and Afghanistan conflicts', Journal of Neurology Neurosurgery and Psychiatry, vol. 91, no. 4, pp. 359-365. https://doi.org/10.1136/jnnp-2019-321723

Bhangu, A, Nepogodiev, D, Rowland, N, Magill, L, Glasbey, J, Forde, C, Bisgaard, T, Handley, K, Mehta, S, Morton, D, Pinkney, T & Beggs, A 2020, 'Prophylactic biological mesh reinforcement versus standard closure of stoma site (ROCSS): a multicentre, randomised controlled trial', The Lancet, vol. 395, no. 10222, pp. 417-426. https://doi.org/10.1016/S0140-6736(19)32637-6

Kwok, MCK, Oldreive, C, Rawstron, AC, Goel, A, Papatzikas, G, Jones, R, Drennan, S, Agathanggelou, A, Sharma-Oates, A, Evans, P, Smith, E, Dalal, S, Mao, J, Hollows, R, Gordon, N, Hamada, M, Davies, N, Parry, H, Beggs, A, Munir, T, Moreton, P, Paneesha, S, Pratt, G, Taylor, M, Forconi, F, Baird, D, Cazier, J-B, Moss, P, Hillmen, P & Stankovic, T 2020, 'Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL: natural history and mechanism of spontaneous CLL regression', Blood, vol. 135, no. 6, pp. 411-428. https://doi.org/10.1182/blood.2019001262

Quraishi, MN, Acharjee, A, Beggs, AD, Horniblow, R, Tselepis, C, Gkoutos, G, Ghosh, S, Rossiter, A, Loman, N, van Schaik, W, Withers, D, Walters, JRF, Hirschfield, GM & Iqbal, TH 2020, 'A pilot integrative analysis of colonic gene expression, gut microbiota and immune infiltration in primary sclerosing cholangitis-inflammatory bowel disease: association of disease with bile acid pathways', Journal of Crohn's & Colitis. https://doi.org/10.1093/ecco-jcc/jjaa021

OCCAMS Consortium & Beggs, A 2020, 'Machine learning to predict early recurrence after oesophageal cancer surgery', British Journal of Surgery. https://doi.org/10.1002/bjs.11461

Althubaiti, S, Karwath, A, Dallol, I, Noor, A, Alkhayyat, SS, Alwassia, R, Mineta, K, Gojobori, T, Beggs, A, Schofield, PN, Gkoutos, G & Hoehndorf, R 2019, 'Ontology-based prediction of cancer driver genes', Scientific Reports, vol. 9, 17405. https://doi.org/10.1038/s41598-019-53454-1

Kleeman, SO, Koelzer, VH, Jones, HJ, Vazquez, EG, Davis, H, East, JE, Arnold, R, Koppens, MA, Blake, A, Domingo, E, Cunningham, C, Beggs, AD, Pestinger, V, Loughrey, MB, Wang, L-M, Lannagan, TR, Woods, SL, Worthley, D, Consortium, SC, Tomlinson, I, Dunne, PD, Maughan, T & Leedham, SJ 2019, 'Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification', Gut. https://doi.org/10.1136/gutjnl-2019-319126

Brooks, J, Antao Mobre De Menezes, ARE, Ibrahim, M, Archer, L, Lal, N, Bagnall, C, Zeidler, SVV, Valentine, H, Spruce, R, Batis, N, Bryant, J, Hartley, M, Kaul, B, Ryan, G, Bao, R, Khattri, A, Lee, S, Ogbureke, KUE, Middleton, G, Tennant, D, Beggs, A, Deeks, J, West, CML, Cazier, J-B, Willcox, B, Seiwert, TY & Mehanna, H 2019, 'Development and validation of a combined hypoxia and immune prognostic classifier for head and neck cancer', Clinical Cancer Research, vol. 25, no. 17, pp. 5315-5328. https://doi.org/10.1158/1078-0432.CCR-18-3314

Ward, D, Gordon, N, Boucher, R, Pirrie, S, Baxter, L, Ott, S, Silcock, L, Whalley, C, Stockton, J, Beggs, A, Griffiths, M, Abbotts, B, Ijakipour, H, Latheef, F, Robinson, R, White, A, James, N, Zeegers, M, Cheng, KK & Bryan, R 2019, 'Targeted deep sequencing of urothelial bladder cancers and associated urinary DNA: a 23-gene panel with utility for non-invasive diagnosis and risk stratification', BJU international, vol. 124, no. 3, pp. 532-544. https://doi.org/10.1111/bju.14808

Review article

Tyler, R, Wanigasooriya, K, Taniere, P, Almond, M, Ford, S, Desai, A & Beggs, A 2020, 'A review of retroperitoneal liposarcoma genomics', Cancer Treatment Reviews, vol. 86, 102013. https://doi.org/10.1016/j.ctrv.2020.102013

Hallam, S, Tyler, R, Price, M, Beggs, A & Youssef, H 2019, 'Meta-analysis of prognostic factors for patients with colorectal peritoneal metastasis undergoing cytoreductive surgery and heated intraperitoneal chemotherapy: Prognostic factors in colorectal peritoneal metastasis', BJGP Open, vol. 3, no. 5, pp. 585-594. https://doi.org/10.1002/bjs5.50179

Sillo, TO, Beggs, AD, Morton, DG & Middleton, G 2019, 'Mechanisms of immunogenicity in colorectal cancer', British Journal of Surgery, vol. 106, no. 10, pp. 1283-1297. https://doi.org/10.1002/bjs.11204

View all publications in research portal