Cauchy P, James SR, Zacarias-Cabeza J, Ptasinska A, Imperato MR, Assi SA, Piper J, Canestraro M, Hoogenkamp M, Raghavan M, Loke C, Akiki S, Clokie SJ, Richards SJ, Westhead DR, Griffiths MJ, Ott S, Bonifer C and Cockerill PN. (2015) Chronic FLT3-ITD signaling in Acute Myeloid Leukemia is connected to a specific chromatin signature. Cell Reports 12, 821-836. doi: 10.1016/j.celrep.2015.06.069
Bevington SL, Cauchy P, Piper J, Bertrand E, Lalli N, Jarvis RC, Gilding LN, Ott S, Bonifer C and Cockerill PN. (2016) Inducible chromatin priming is associated with the establishment of immunological memory in T cells. EMBO J 35, 515-535. doi: 10.15252/embj.201592534
Bevington SL, Cauchy P and Cockerill PN Chromatin priming elements establish immunological memory in T cells without activating transcription. (2017) Bioessays 2016 Dec 27. doi: 10.1002/bies.201600184.
Bevington SL, Cauchy P, Wither DR, Lane PJL, and Cockerill PN. (2017) T Cell Receptor and cytokine signalling can function at different stages to establish and maintain transcriptional memory and enable T helper cell differentiation. Frontiers in Immunology 03 March 2017 doi: 10.3389/fimmu.2017.00204
Bonifer C, Cockerill PN. Chromatin priming of genes in development: Concepts, mechanisms and consequences. Exp Hematol. 2017 Feb 7. pii: S0301-472X(17)30013-9. doi: 10.1016/j.exphem.2017.01.003
Loke J, Assi SA, Imperato MR, Ptasinska A, Cauchy P, Grabovska Y, Martinez Soria N, Raghavan M, Delwel HR, Cockerill PN, Heidenreich O, and Bonifer C. RUNX1-ETO and RUNX1-EVI1 differentially re-program the chromatin landscape in t(8;21) and t(3;21) AML. ( 2017) Cell Reports. 19, 1654-1668, 2017. doi.org/10.1016/j.celrep.2017.05.005
Brignall R, Cauchy P, Bevington SL, Gorman B, Pisco AO, Bagnall J, Boddington C, Rowe W, England H, Rich K, Schmidt L, Dyer NP, Travis MA, Ott S, Jackson DA, COCKERILL PN, Paszek P. Integration of Kinase and Calcium Signaling at the Level of Chromatin Underlies Inducible Gene Activation in T Cells. Journal of Immunology 199, 2652-2667, 2017.
Loke J, Chin PS, Keane P, Pickin A, Assi SA, Ptasinska A, Imperato MR, COCKERILL PN and Bonifer B. C/EBPα overrides epigenetic reprogramming by oncogenic transcription factors in Acute Myeloid Leukemia. Blood Advances 2, 271-284, 2018. doi: https://doi.org/10.1182/bloodadvances.2017012781
Assi SA, Imperato MR, Coleman DJL, Pickin A, Potluri S, Ptasinska A, Chin PS, Cauchy P, James SR, Zacarias-Cabeza J, Gilding LN, Beggs A, Clokie S, Loke JC, Jenkin P, Uddin A, Delwel HR, Richards SJ, Raghavan M, Griffiths MJ, COCKERILL PN, BoniferC. Subtype-specific regulatory network rewiring in acute myeloid leukemia. Nature Genetics 51: 151-162 (2019). https://www.nature.com/articles/s41588-018-0270-1
Edginton-White B, Pierre Cauchy P, Assi SA, Hartmann H, Riggs AG, Mathas S, COCKERILL PN and Bonifer C. Global Long Terminal Repeat activation participates in establishing the unique gene expression program of Hodgkin’s Lymphoma. Leukemia 33, 1463-1474 (2019). doi: 10.1038/s41375-018-0311-x.
Assi SA, Bonifer C, and COCKERILL PN. Rewiring of the transcription factor network in acute myeloid leukemia. Cancer Informatics (25 June 2019) 18:1176935119859863.
Ptasinska A, Pickin, A., Assi SA, Chin P, Ames L, Avellino R, Delwel HR, COCKERILL PN Osborne C, and Bonifer C. RUNX1-ETO depletion in t(8;21) AML leads to C/EBPa and AP-1 mediated alterations in enhancer promoter interaction. Cell Reports 28, 3022–3031 (2019).doi: 10.1016/j.celrep.2019.08.040
Bevington SL, Ng S, Keane P, Wraith DC and Cockerill PN. Immunological tolerance is associated with epigenetic priming of inhibitory protein genes and suppression of signaling to immune response genes. Cell Reports 31:107748 (2020). doi: 10.1016/j.celrep.2020.107748.
Bevington SL, Keane P, Soley JK, Tauch S, Gajdasik DW, Fiancette R, Matei-Rascu V, Willis CM, Withers DR, and COCKERILL PN. IL-2/IL-7-inducible factors pioneer the path to T cell differentiation in advance of lineage-defining factors. EMBO J: e105220 (2020).
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