Dr Martin R. Higgs

Martin Higgs

Institute of Cancer and Genomic Sciences
Birmingham Fellow for Genomics and Rare Diseases
MRC Career Development Fellow
Deputy Director, Centre for Rare Disease Studies

Contact details

Telephone
+44 (0)121 414 8480
Email
m.r.higgs@bham.ac.uk
View my research portal
Address
Institute of Cancer and Genomic Sciences: IBR West Extension
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Martin Higgs is a group leader in the Institute of Cancer and Genomic Sciences. He is currently Birmingham Fellow for Genomics and Rare Disease, and leads a research group working on the cellular response to genotoxic stress.

Martin’s area of expertise is the study of a single post-translational modification, known as Lysine methylation, and how this regulates the cellular response to DNA damage. He has published papers in top journals, such as Molecular Cell, Oncogene, Cancer Research and Nature Genetics, and has been invited to speak at both national and international conferences.

In addition, part of his work focuses on the role of lysine methylation in ensuring human development and preventing rare human diseases. He has particular interests in studying neurodevelopmental disorders caused by mutations in the lysine methylation apparatus. He is also Deputy Director for the Centre for Rare Disease Studies (CRDS) Birmingham.

He also maintains a long-standing interest in the impact of chronic viral infection on this process, and on the consequences of this on the DNA damage response during tumourigenesis.

Qualifications

  • PG Certificate in HE, 2020
  • PhD in Virology, University of Glasgow, 2008
  • BSc in Molecular & Cellular Biology, University of Stirling, 2004

Biography

Martin graduated with a BSc from the University of Stirling in 2003. He then worked in Leeds with Professor Mark Harris on characterising the hepatitis C virus (HCV) protein p7, before moving to the (former) MRC Virology Unit in Glasgow to study for his PhD with Dr Nigel Stow.

He then undertook post-doctoral research in the laboratory of Professor Jean-Michel Pawlotsky in Paris, France, on the impact of HCV on the cellular response to DNA damage and cellular signalling. 

In 2012, he moved to the University of Birmingham to join the group of Professor Grant Stewart, where he studied novel actors in the cellular response to replication stress. 

In 2016, he was awarded an MRC Career Development Fellowship and was appointed Birmingham Fellow in Genomics and Rare Disease, and established his research group in 2017.

Teaching

Teaching management

  • Module co-lead: MRes Cancer Sciences/MSc Clinical Oncology: Cellular and Molecular Basis of Cancer
  • Module deputy lead: MBChB: Cancer - Causes to Cures (Year 2)

Teaching delivery

  • BSc Biomedical Science: Advanced Molecular Genetics (Year 2)
  • BSc Biomedical Science: Clinical and Stratified Medicine (Year 2)
  • BSc Biomedical Science: Cancer Pathogenesis and Treatment (Year 3)
  • BSc Biomedical Science DNA Damage Response (Year 3)
  • MBChB Cancer: Causes to Cures (Year 2)
  • MRes Cancer Sciences: Cellular and Molecular Basis of Cancer
  • MSc Clinical Oncology: Cellular and Molecular Basis of Cancer
  • MSc Clinical Oncology: Radiation Biology

Postgraduate supervision

Martin’s area of expertise is in the cellular response to DNA damage, and examining the role of lysine methylation in the process. He is also interested in examining the impact of mutations in lysine methylation pathways on human health.

Martin is currently supervising doctoral and master’s students in studying how lysine methylation regulates cancer therapeutic efficacy and DNA repair. Previous students have gone on to further academic study, careers in life sciences, or PhDs.

He is always interested in supervising keen and motiviated individuals: if you are seeking a PhD position in the fields of DNA repair and/or human genetics, and have an excellent and competitive CV, then please contact him directly.

Research

Martin’s current research focuses around identifying how cells respond to and resolve DNA damage, particularly that arising during DNA replication.

He is particularly interested in elucidating how protein Lysine methylation contributes to safeguarding genome stability, and in identifying novel factors involved in this response. He is also interested in elucidating how deficiencies in these pathways contribute to human disease.

He also maintains a long-standing interest in the impact of chronic viral infection on this process, and on the consequences of this on the DNA damage response during carcinogenesis.

Other activities

Reviewer for grant funding bodies and journals, including Oncogene, Nucleic Acids Research, MRC, BBSRC and the NIH.

Publications

Recent publications

Article

Wang, J, Rojas, P, Mao, J, Muste Sadurni, M, Garnier, O, Xiao, S, Higgs, M, Garcia, P & Saponaro, M 2021, 'Persistence of RNA transcription during DNA replication delays duplication of transcription start sites until G2/M', Cell Reports, vol. 34, no. 7, 108759. https://doi.org/10.1016/j.celrep.2021.108759

Kummerling, J, Stremmelaar, DE, Raun, N, Reijnders, MRF, Willemsen, MH, Ruiterkamp-Versteeg, M, Schepens, M, Man, CCO, Gilissen, C, Cho, MT, McWalter, K, Sinnema, M, Wheless, JW, Simon, MEH, Genetti, CA, Casey, AM, Terhal, PA, van der Smagt, JJ, van Gassen, KLI, Joset, P, Bahr, A, Steindl, K, Rauch, A, Keller, E, Raas-Rothschild, A, Koolen, DA, Agrawal, PB, Hoffman, TL, Powell-Hamilton, NN, Thiffault, I, Engleman, K, Zhou, D, Bodamer, O, Hoefele, J, Riedhammer, KM, Schwaibold, EMC, Tasic, V, Schubert, D, Top, D, Pfundt, R, Higgs, M, Kramer, JM & Kleefstra, T 2020, 'Characterization of SETD1A haploinsufficiency in humans and Drosophila defines a novel neurodevelopmental syndrome', Molecular Psychiatry. https://doi.org/10.1038/s41380-020-0725-5

The COMPLEXO Network 2020, 'Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability', Journal of Clinical Investigation, vol. 130, no. 8, pp. 4069-4080. https://doi.org/10.1172/JCI127521

Wing, P, Davenne, T, Wettengel, J, Lai, AG, Zhuang, X, Chakraborty, A, d'Arienzo, V, Kramer, C, Ko, C, Harris, J, Schreiner, S, Higgs, M, Roessler, S, Parish, J, Protzer, U, Balfe, P, Rehwinkel, J & McKeating, JA 2019, 'A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis', Life Science Alliance, vol. 2, no. 2. https://doi.org/10.26508/lsa.201900355

Burrage, L, Reynolds, J, Baratang, N, Phillips, J, Wegner, J, McFarquhar, A, Higgs, M, Christiansen, A, Lanza, D, Seavitt, J, Jain, M, Li, X, Parry, D, Raman, V, Chitayat, D, Chinn, I, Bertuch, A, Karaviti, L, Schlesinger, A, Earl, D, Bamshad, M, Savarirayan, R, Doddapaneni, H, Muzny, D, Jhangiani, S, Eng, C, Gibbs, R, Bi, W, Emrick, L, Rosenfeld, J, Postlethwait, J, Westerfield, M, Dickinson, M, Beaudet, A, Ranza, E, Huber, C, Cormier-Daire, V, Shen, W, Mao, R, Heaney, J, Orange, J, Undiagnosed Diseases Network, Bertola, D, Yamamoto, G, Baratela, W, Butler, M, Ali, A, Adeli, M, Cohn, D, Krakow, D, Jackson, A, Lees, M, Offiah, A, Carlston, C, Carey, J, Stewart, G, Bacino, C, Campeau, P & Lee, B 2019, 'Biallelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes', American Journal of Human Genetics, vol. 104, no. 3, pp. 422-438. https://doi.org/10.1016/j.ajhg.2019.01.007

Chang, HR, Cho, SY, Lee, JH, Lee, E, Soo, J, Lee, HR, Cavalcanti, DP, Mäkitie, O, Valta, H, Girisha, KM, Lee, C, Neethukrishna, K, Bhavani, GS, Shukla, A, Nampoothiri, S, Phadke, SR, Park, MJ, Ikegawa, S, Wang, Z, Higgs, M, Stewart, G, Jung, E, Lee, M-S, Park, JH, Lee, EA, Kim, H, Myung, K, Jeon, W, Lee, K, Kim, D, Kim, O-H, Choi, M, Lee, H-W, Kim, Y & Cho, T-J 2019, 'Hypomorphic Mutations in TONSL Cause SPONASTRIME Dysplasia', American Journal of Human Genetics, vol. 104, no. 3, pp. 439-453. https://doi.org/10.1016/j.ajhg.2019.01.009

Higgs, M, Sato, K, Reynolds, J, Begum, S, Bayley, R, Goula, A, Vernet, A, Paquin, K, Skalnik, D, Kobayashi, W, Takata, M, Howlett, N, Kurumizaka, H, Kimura, H & Stewart, G 2018, 'Histone methylation by SETD1A protects nascent DNA through the nucleosome chaperone activity of FANCD2', Molecular Cell, vol. 71, no. 1, pp. 25-41.e6. https://doi.org/10.1016/j.molcel.2018.05.018

Bayley, R, Blakemore, D, Cancian, L, Dumon, S, Volpe, G, Ward, C, Ward, C, Almaghrabi, R, Gujar, J, Reeve, N, Raghavan, M, Higgs, MR, Stewart, GS, Petermann, E & García, P 2018, 'MYBL2 Supports DNA Double Strand Break Repair in Hematopoietic Stem Cells.', Cancer Research. https://doi.org/10.1158/0008-5472.can-18-0273

Bayley, R, Blakemore, D, Cancian, L, Dumon, S, Volpe, G, Ward, C, Al Maghrabi, R, Gujar, J, Reeve, N, Raghavan, M, Higgs, M, Stewart, G, Petermann, E & Garcia, P 2018, 'MYBL2 supports DNA double strand break repair in haematopoietic stem cells', Cancer Research, vol. 78, no. 20, pp. 5767-5779. https://doi.org/10.1158/0008-5472.CAN-18-0273

Ronson, G, Piberger, AL, Higgs, M, Olsen, A, Stewart, G, McHugh, P, Petermann, E & Lakin, N 2018, 'PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation', Nature Communications, vol. 9, no. 1, 746. https://doi.org/10.1038/s41467-018-03159-2

Marsh, E, Delury, C, Davies, N, Weston, C, Miah, MAL, Banks, L, Parish, J, Higgs, M & Roberts, S 2017, 'Mitotic control of human papillomavirus genome-containing cells is regulated by the function of the PDZ-binding motif of the E6 oncoprotein', OncoTarget, vol. 8, pp. 19491-19506. https://doi.org/10.18632/oncotarget.14469

Reynolds, J, Higgs, M, Zlatanou, A, Vernet, A, Mottram, R, Brean, A, Taylor, M, Alkuraya, FS, Mathew, CG, Jackson, AP & Stewart, G 2017, 'Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism', Nature Genetics, vol. 49, pp. 537–549. https://doi.org/10.1038/ng.3790

Higgs, M & Stewart, G 2016, 'Protection or resection: BOD1L as a novel replication fork protection factor', Nucleus (Austin). https://doi.org/10.1080/19491034.2016.1143183

Comment/debate

Begum, S, Goula, A, Bayley, R & Higgs, M 2018, 'On your marks, get SET(D1A): the race to protect stalled replication forks', Molecular and Cellular Oncology, vol. 5, no. 6, e1511209. https://doi.org/10.1080/23723556.2018.1511209

Preprint

Mahony, CB, Noyvert, B, Vrljicak, P, Ott, S, Higgs, M & Monteiro, R 2021 'Gata2a maintains cebpa and npm1a in haematopoietic stem cells to sustain lineage differentiation and genome stability' bioRxiv. https://doi.org/10.1101/2021.07.19.452890

View all publications in research portal