Recent publications
Article
Saponaro, M, Rojas, P, Wang, J, Mao, J, Muste Sadurni, M, Garnier, O, Xiao, S, Garcia, P & Higgs, M 2021, 'Persistence of RNA transcription during DNA replication delays duplication of transcription start sites until G2/M', Cell Reports.
Kummerling, J, Stremmelaar, DE, Raun, N, Reijnders, MRF, Willemsen, MH, Ruiterkamp-Versteeg, M, Schepens, M, Man, CCO, Gilissen, C, Cho, MT, McWalter, K, Sinnema, M, Wheless, JW, Simon, MEH, Genetti, CA, Casey, AM, Terhal, PA, van der Smagt, JJ, van Gassen, KLI, Joset, P, Bahr, A, Steindl, K, Rauch, A, Keller, E, Raas-Rothschild, A, Koolen, DA, Agrawal, PB, Hoffman, TL, Powell-Hamilton, NN, Thiffault, I, Engleman, K, Zhou, D, Bodamer, O, Hoefele, J, Riedhammer, KM, Schwaibold, EMC, Tasic, V, Schubert, D, Top, D, Pfundt, R, Higgs, M, Kramer, JM & Kleefstra, T 2020, 'Characterization of SETD1A haploinsufficiency in humans and Drosophila defines a novel neurodevelopmental syndrome', Molecular Psychiatry. https://doi.org/10.1038/s41380-020-0725-5
The COMPLEXO Network 2020, 'Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability', Journal of Clinical Investigation, vol. 130, no. 8, pp. 4069-4080. https://doi.org/10.1172/JCI127521
Wing, P, Davenne, T, Wettengel, J, Lai, AG, Zhuang, X, Chakraborty, A, d'Arienzo, V, Kramer, C, Ko, C, Harris, J, Schreiner, S, Higgs, M, Roessler, S, Parish, J, Protzer, U, Balfe, P, Rehwinkel, J & McKeating, JA 2019, 'A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis', Life Science Alliance, vol. 2, no. 2. https://doi.org/10.26508/lsa.201900355
Burrage, L, Reynolds, J, Baratang, N, Phillips, J, Wegner, J, McFarquhar, A, Higgs, M, Christiansen, A, Lanza, D, Seavitt, J, Jain, M, Li, X, Parry, D, Raman, V, Chitayat, D, Chinn, I, Bertuch, A, Karaviti, L, Schlesinger, A, Earl, D, Bamshad, M, Savarirayan, R, Doddapaneni, H, Muzny, D, Jhangiani, S, Eng, C, Gibbs, R, Bi, W, Emrick, L, Rosenfeld, J, Postlethwait, J, Westerfield, M, Dickinson, M, Beaudet, A, Ranza, E, Huber, C, Cormier-Daire, V, Shen, W, Mao, R, Heaney, J, Orange, J, Undiagnosed Diseases Network, Bertola, D, Yamamoto, G, Baratela, W, Butler, M, Ali, A, Adeli, M, Cohn, D, Krakow, D, Jackson, A, Lees, M, Offiah, A, Carlston, C, Carey, J, Stewart, G, Bacino, C, Campeau, P & Lee, B 2019, 'Biallelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes', American Journal of Human Genetics, vol. 104, no. 3, pp. 422-438. https://doi.org/10.1016/j.ajhg.2019.01.007
Chang, HR, Cho, SY, Lee, JH, Lee, E, Soo, J, Lee, HR, Cavalcanti, DP, Mäkitie, O, Valta, H, Girisha, KM, Lee, C, Neethukrishna, K, Bhavani, GS, Shukla, A, Nampoothiri, S, Phadke, SR, Park, MJ, Ikegawa, S, Wang, Z, Higgs, M, Stewart, G, Jung, E, Lee, M-S, Park, JH, Lee, EA, Kim, H, Myung, K, Jeon, W, Lee, K, Kim, D, Kim, O-H, Choi, M, Lee, H-W, Kim, Y & Cho, T-J 2019, 'Hypomorphic Mutations in TONSL Cause SPONASTRIME Dysplasia', American Journal of Human Genetics, vol. 104, no. 3, pp. 439-453. https://doi.org/10.1016/j.ajhg.2019.01.009
Higgs, M, Sato, K, Reynolds, J, Begum, S, Bayley, R, Goula, A, Vernet, A, Paquin, K, Skalnik, D, Kobayashi, W, Takata, M, Howlett, N, Kurumizaka, H, Kimura, H & Stewart, G 2018, 'Histone methylation by SETD1A protects nascent DNA through the nucleosome chaperone activity of FANCD2', Molecular Cell, vol. 71, no. 1, pp. 25-41.e6. https://doi.org/10.1016/j.molcel.2018.05.018
Bayley, R, Blakemore, D, Cancian, L, Dumon, S, Volpe, G, Ward, C, Al Maghrabi, R, Gujar, J, Reeve, N, Raghavan, M, Higgs, M, Stewart, G, Petermann, E & Garcia, P 2018, 'MYBL2 supports DNA double strand break repair in haematopoietic stem cells', Cancer Research, vol. 78, no. 20, pp. 5767-5779. https://doi.org/10.1158/0008-5472.CAN-18-0273
Ronson, G, Piberger, AL, Higgs, M, Olsen, A, Stewart, G, McHugh, P, Petermann, E & Lakin, N 2018, 'PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation', Nature Communications, vol. 9, no. 1, 746. https://doi.org/10.1038/s41467-018-03159-2
Marsh, E, Delury, C, Davies, N, Weston, C, Miah, MAL, Banks, L, Parish, J, Higgs, M & Roberts, S 2017, 'Mitotic control of human papillomavirus genome-containing cells is regulated by the function of the PDZ-binding motif of the E6 oncoprotein', OncoTarget, vol. 8, pp. 19491-19506. https://doi.org/10.18632/oncotarget.14469
Reynolds, J, Higgs, M, Zlatanou, A, Vernet, A, Mottram, R, Brean, A, Taylor, M, Alkuraya, FS, Mathew, CG, Jackson, AP & Stewart, G 2017, 'Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism', Nature Genetics, vol. 49, pp. 537–549. https://doi.org/10.1038/ng.3790
Higgs, M & Stewart, G 2016, 'Protection or resection: BOD1L as a novel replication fork protection factor', Nucleus (Austin). https://doi.org/10.1080/19491034.2016.1143183
Harley, ME, Murina, O, Leitch, A, Higgs, M, Bicknell, LS, Yigit, G, Blackford, AN, Zlatanou, A, Mackenzie, KJ, Reddy, K, Halachev, M, McGlasson, S, Reijns, MAM, Fluteau, A, Martin, C-A, Sabbioneda, S, Elcioglu, NH, Altmüller, J, Thiele, H, Greenhalgh, L, Chessa, L, Maghnie, M, Salim, M, Bober, MB, Nürnberg, P, Jackson, SP, Hurles, ME, Wollnik, B, Stewart, G & Jackson, A 2016, 'TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism', Nature Genetics, vol. 48, no. 1, pp. 36-43. https://doi.org/10.1038/ng.3451
Higgs, M, Reynolds, J, Winczura, A, Blackford, AN, Borel, V, Miller, E, Zlatanou, A, Nieminuszczy, J, Ryan, E, Davies, N, Stankovic, T, Boulton, S, Niedzwiedz, W & Stewart, G 2015, 'Bod1l is required to suppress deleterious resection of stressed replication forks', Molecular Cell, vol. 59, no. 3, pp. 462-477. https://doi.org/10.1016/j.molcel.2015.06.007
Comment/debate
Begum, S, Goula, A, Bayley, R & Higgs, M 2018, 'On your marks, get SET(D1A): the race to protect stalled replication forks', Molecular and Cellular Oncology, vol. 5, no. 6, e1511209. https://doi.org/10.1080/23723556.2018.1511209
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