Dr Justin Loke BM BCh PhD MRCP FRCPath

Dr Justin Loke

Institute of Cancer and Genomic Sciences
AACR- CRUK Transatlantic Fellow

Contact details

Twitter
@jloke1
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Address
Centre for Clinical Haematology
Queen Elizabeth Hospital
Mindelsohn Way
Birmingham
B15 2GW

Dr Justin Loke trained at University of Cambridge and Oxford Medical School and then completed postgraduate haematology training in Birmingham. His specialist interest is in Acute Myeloid Leukaemia (AML) and he completed a PhD at the University of Birmingham under the supervision of Professor Constanze Bonifer in the epigenetic deregulation of AML, for which he was awarded a number of prizes from the Royal Society of Medicine and the Royal College of Pathologists.

Dr Loke subsequently completed a post-CCT fellowship with CRUK Clinical Trials Unit, Birmingham, and was a Consultant Haematologist at the Queen Elizabeth Hospital, Birmingham where he was involved in the development of supportive care studies in AML (PACE) and in the running of IMPACT transplant studies. 

He is currently an AACR-CRUK Transatlantic Fellow based in the Dana Farber Cancer Institute, Boston, USA with Professor Ben Ebert.

Qualifications

  • Fellow of the Royal College of Pathologists 2018
  • PhD, University of Birmingham 2017
  • Member of the Royal College of Physicians 2011
  • BM BCh, University of Oxford 2008
  • Master of Arts, University of Cambridge 2005

Teaching

  • Teaching programme for the West Midlands Haematology Registrars
  • Associate of Higher Education Academy

Other activities

  • NCRI AML Working Party Subgroup
  • NCRI AML Supportive Care Secretary
  • EBMT Acute Leukaemia Working Party
  • Certificate of Completion of Training- Haematology 2019

Publications

Recent publications

Article

Loke, J, Metzner, M, Boucher, R, Jackson, A, Hopkins, L, Pavlu, J, Tholouli, E, Drummond, M, Peniket, A, Bishop, R, Fox, S, Vyas, P & Craddock, C 2021, 'Combination romidepsin and azacitidine therapy is well tolerated and clinically active in adults with high-risk acute myeloid leukaemia ineligible for intensive chemotherapy', British Journal of Haematology. https://doi.org/10.1111/bjh.17823

Craddock, C, Jackson, A, Loke, J, Siddique, S, Hodgkinson, A, Mason, J, Andrew, G, Nagra, S, Malladi, R, Peniket, A, Gilleece, M, Salim, R, Tholouli, E, Potter, V, Crawley, C, Wheatley, K, Protheroe, R, Vyas, P, Hunter, A, Parker, A, Wilson, K, Pavlu, J, Byrne, J, Dillon, R, Khan, N, Mccarthy, N & Freeman, SD 2020, 'Augmented reduced-intensity regimen does not improve postallogeneic transplant outcomes in acute myeloid leukemia', Journal of Clinical Oncology . https://doi.org/10.1200/JCO.20.02308

Assi, SA, Imperato, MR, Coleman, DJL, Pickin, A, Potluri, S, Ptasinska, A, Chin, PS, Blair, H, Cauchy, P, James, SR, Zacarias-cabeza, J, Gilding, LN, Beggs, A, Clokie, S, Loke, JC, Jenkin, P, Uddin, A, Delwel, R, Richards, SJ, Raghavan, M, Griffiths, MJ, Heidenreich, O, Cockerill, PN & Bonifer, C 2019, 'Subtype-specific regulatory network rewiring in acute myeloid leukemia', Nature Genetics, vol. 51, no. 1, pp. 151-162. https://doi.org/10.1038/s41588-018-0270-1

Loke, J, Chin, PS, Keane, P, Pickin, A, Assi, S, Ptasinska, A, Imperato, M, Cockerill, P & Bonifer, C 2018, 'C/EBPα overrides epigenetic reprogramming by oncogenic transcription factors in acute myeloid leukemia', Blood Advances, vol. 2, no. 3, pp. 271-284. https://doi.org/10.1182/bloodadvances.2017012781, https://doi.org/10.1182/bloodadvances.2017012781

Malaker, SA, Penny, SA, Steadman, LG, Myers, PT, Loke, JC, Raghavan, M, Bai, DL, Shabanowitz, J, Hunt, DF & Cobbold, M 2017, 'Identification of Glycopeptides as Posttranslationally Modified Neoantigens in Leukemia', Cancer immunology research, vol. 5, no. 5, pp. 376-384. https://doi.org/10.1158/2326-6066.CIR-16-0280

Loke, J, Assi, SA, Imperato, MR, Ptasinska, A, Cauchy, P, Grabovska, Y, Soria, NM, Raghavan, M, Delwel, HR, Cockerill, PN, Heidenreich, O & Bonifer, C 2017, 'RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML', Cell Reports, vol. 19, no. 8, pp. 1654-1668. https://doi.org/10.1016/j.celrep.2017.05.005

Loke, J, Akiki, S, Borrow, J, Ewing, J, Bokhari, S, Chandra, D, Arrazi, J, Hazlewood, P, Arthur, K, Walsh, J, Membwange, Y, Wandroo, F, Watts, A, Borg, A, Brock, K, Ferguson, P, Craddock, C, Griffiths, M & Raghavan, M 2015, 'Acquired Isodisomy on Chromosome 13 at diagnosis results in impaired overall survival in Patients with FLT3-ITD mutant Acute Myeloid Leukaemia', Leukemia, vol. 29, no. 12, pp. 2404-2407. https://doi.org/10.1038/leu.2015.148

Mussai, F, Egan, S, Higginbotham-Jones, J, Perry, T, Beggs, A, Odintsova, E, Loke, J, Pratt, G, U, KP, Lo, A, Ng, M, Kearns, P, Cheng, P & De Santo, C 2015, 'Arginine dependence of acute myeloid leukemia blast proliferation: a novel therapeutic target', Blood, vol. 125, no. 15, pp. 2386-2396. https://doi.org/10.1182/blood-2014-09-600643

Cauchy, P, James, SR, Zacarias Cabeza, J, Ptasinska, A, Imperato, M, Assi, SA, Piper, J, Canestraro, M, Hoogenkamp, M, Raghavan, M, Loke, J, Akiki, S, Clokie, SJ, Richards, SJ, Westhead, DR, Griffiths, M, Ott, S, Bonifer, C & Cockerill, P 2015, 'Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature', Cell Reports, vol. 12, no. 5, pp. 821-836. https://doi.org/10.1016/j.celrep.2015.06.069

Loke, J, Khan, JN, Wilson, J, Craddock, C & Wheatley, K 2015, 'Mylotarg has potent anti-leukaemic effect: a systematic review and meta-analysis of anti-CD33 antibody treatment in acute myeloid leukaemia', Annals of Hematology, vol. 94, no. 3, pp. 361-373. https://doi.org/10.1007/s00277-014-2218-6

Loke, J, Khan, J, Wilson, J, Craddock, C & Wheatley, K 2014, 'Systematic review and meta-analysis of anti-CD33 antibody treatment in AML', British Journal of Haematology, vol. 165, pp. 4. https://doi.org/10.1111/bjh.12802

Review article

Loke, J, Malladi, R, Moss, P & Craddock, C 2019, 'The role of allogeneic stem cell transplantation in the management of acute myeloid leukaemia: a triumph of hope and experience', British Journal of Haematology, vol. 188, no. 1, pp. 129-146. https://doi.org/10.1111/bjh.16355

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