Rui started his research career as an undergraduate, studying Notch target genes in chick embryos at the Instituto de Histologia e Embriologia, University of Lisbon, Portugal. After graduating in 2000, he went on to pursue a PhD in Developmental Biology at the Hubrecht Institute, University of Utrecht, The Netherlands. He graduated in 2005, and during this period studied BMP signalling in mouse and in zebrafish. In 2006 he joined Prof Patient’s lab at the Weatherall Institute of Molecular Medicine, University of Oxford to do research on developmental haematopoiesis. In 2014, he was awarded a BHF Intermediate Basic Science Research Fellowship and became a Principal Investigator at the Radcliffe Department of Medicine, University of Oxford. He became a University Research Lecturer in 2016. Rui joined the University of Birmingham in 2018 as a Birmingham Fellow.