Recent publications
Article
Obergassel, J, Lemoine, MD, Sommerfeld, LC, Rieß, JL, Al-Aqili, S, Jäckle, SJ, Rottner, L, Rillig, A, Metzner, A, Sörensen, NA, Fabritz, L, Renné, T, Twerenbold, R, Blankenberg, S, Zeller, T, Kirchhof, P & Neumann, JT 2025, 'Comparison of cardiac troponin assays reveals assay-specific sensitivities in a clinical model of very acute myocardial injury', European Heart Journal: Acute Cardiovascular Care, vol. 14, no. 9, pp. 552-561. https://doi.org/10.1093/ehjacc/zuaf064
Metzner, A, Willems, S, Borof, K, Breithardt, G, Camm, AJ, Crijns, HJGM, Eckardt, L, Fabritz, L, Gessler, N, Goette, A, Reissmann, B, Schnabel, RB, Schotten, U, Zapf, A, Rillig, A & Kirchhof, P 2025, 'Diabetes and Obesity and Treatment Effect of Early Rhythm Control vs Usual Care in Patients With Atrial Fibrillation: A Secondary Analysis of the EAST-AFNET 4 Randomized Clinical Trial', JAMA Cardiology, vol. 10, no. 9, pp. 932-941. https://doi.org/10.1001/jamacardio.2025.2374
Csengeri, D, Engler, D, Schlieker, P, Ohlrogge, AH, Schofer, N, Kalbacher, D, Fabritz, L, Ziegler, A, Blankenberg, S, Kirchhof, P, Zeller, T & Schnabel, RB 2025, 'Emerging biomarkers for vascular remodeling in volume and pressure overload in a cardiology cohort', IJC Heart and Vasculature, vol. 60, 101768. https://doi.org/10.1016/j.ijcha.2025.101768
Isaacs, A, Zeemering, S, Winters, J, Batlle, M, Bidar, E, Boukens, B, Casadei, B, Chua, W, Crijns, HJGM, Fabritz, L, Guasch, E, Hatem, SN, Hermans, B, Kääb, S, Kawczynski, M, Maesen, B, Maessen, J, Mont, L, Sinner, MF, Wakili, R, Verheule, S, Kirchhof, P, Schotten, U & Stoll, M 2025, 'Lateral Atrial Expression Patterns Provide Insights into Local Transcription Disequilibrium Contributing to Disease Susceptibility', Circulation: Genomic and Precision Medicine, vol. 18, no. 1, e004594, pp. 40-49. https://doi.org/10.1161/CIRCGEN.124.004594
Jurgens, SJ, Melloni, GEM, Kany, S, Fabritz, L, Rämö, JT, Goette, A, Kamanu, FK, Berg, DD, Magnussen, C, Choi, SH, Bonaca, MP, Giugliano, RP, Scirica, BM, Wiviott, SD, Bhatt, DL, Steg, PG, Raz, I, Braunwald, E, Pirruccello, JP, Sabatine, MS, Marston, NA, Kirchhof, P, Ellinor, PT & Ruff, CT 2025, 'Pathogenic Cardiomyopathy-Associated Gene Variants and Prognosis in Atrial Fibrillation: Results in 18,000 Clinical Trial Participants', Journal of the American College of Cardiology, vol. 86, no. 10, pp. 738-753. https://doi.org/10.1016/j.jacc.2025.06.052
Rottner, L, Lemoine, MD, Eckardt, L, Borof, K, Camm, AJ, Goette, A, Breithardt, G, Metzner, A, Schotten, U, Zapf, A, Heidbüchel, H, Willems, S, Crijns, H, Schnabel, RB, Fabritz, L, Magnussen, C, Rillig, A & Kirchhof, P 2025, 'Safety and efficacy of amiodarone and dronedarone for early rhythm control in EAST-AFNET 4', Clinical Research in Cardiology. https://doi.org/10.1007/s00392-025-02637-0
Obergassel, J, Suling, A, Borof, K, Camm, AJ, Crijns, HJGM, Eckardt, L, Fabritz, L, Goette, A, Jensen, M, Lemoine, MD, Magnussen, C, Metzner, A, Rillig, A, Schotten, U, Schnabel, R, Thomalla, G, Vardas, P, Wakili, R, Willems, S, Zapf, A, Kirchhof, P & Schrage, B 2025, 'Short-term benefit of early rhythm control for atrial fibrillation: The EAST-AFNET 4 trial', European Heart Journal, vol. 46, no. 37, pp. 3663-3666. https://doi.org/10.1093/eurheartj/ehaf397
Fabritz, L, Al-Taie, C, Borof, K, Breithardt, G, Camm, AJ, Crijns, HJGM, Roth Cardoso, V, Chua, W, Van Elferen, S, Eckardt, L, Gkoutos, G, Goette, A, Guasch, E, Hatem, S, Metzner, A, Mont, L, Murukutla, VA, Obergassel, J, Rillig, A, Sinner, MF, Schnabel, RB, Schotten, U, Sommerfeld, LC, Wienhues-Thelen, UH, Zapf, A, Zeller, T & Kirchhof, P 2024, 'Biomarker-based prediction of sinus rhythm in atrial fibrillation patients: the EAST-AFNET 4 biomolecule study', European Heart Journal, vol. 45, no. 47, pp. 5002-5019. https://doi.org/10.1093/eurheartj/ehae611
Fabritz, L, Chua, W, Cardoso, VR, Al-Taie, C, Borof, K, Suling, A, Krause, L, Kany, S, Magnussen, C, Wegscheider, K, Breithardt, G, Crijns, HJGM, Camm, AJ, Gkoutos, G, Ellinor, PT, Goette, A, Schotten, U, Wienhues-Thelen, U-H, Zeller, T, Schnabel, RB, Zapf, A & Kirchhof, P 2024, 'Blood-based cardiometabolic phenotypes in atrial fibrillation and their associated risk: EAST-AFNET 4 biomolecule study', Cardiovascular Research, vol. 120, no. 8, pp. 855-868. https://doi.org/10.1093/cvr/cvae067
Chua, W, Khashaba, A, Canagarajah, H, Nielsen, JC, di Biase, L, Haeusler, KG, Hindricks, G, Mont, L, Piccini, J, Schnabel, RB, Schotten, U, Wienhues-Thelen, U-H, Zeller, T, Fabritz, L & Kirchhof, P 2024, 'Disturbed atrial metabolism, shear stress, and cardiac load contribute to atrial fibrillation after ablation: AXAFA biomolecule study', Europace, vol. 26, no. 2, euae028. https://doi.org/10.1093/europace/euae028
Fabritz, L, Fortmueller, L, Gehmlich, K, Kant, S, Kemper, M, Kucerova, D, Syeda, F, Faber, C, Leube, R, Kirchhof, P & Krusche, CA 2024, 'Endurance training provokes Arrhythmogenic Right Ventricular Cardiomyopathy phenotype in heterozygous Desmoglein 2 mutants: Alleviation by preload reduction', Biomedicines, vol. 12, no. 5, 985. https://doi.org/10.3390/biomedicines12050985
Linz, D, Andrade, JG, Arbelo, E, Boriani, G, Breithardt, G, Camm, AJ, Caso, V, Nielsen, JC, De Melis, M, De Potter, T, Dichtl, W, Diederichsen, SZ, Dobrev, D, Doll, N, Duncker, D, Dworatzek, E, Eckardt, L, Eisert, C, Fabritz, L, Farkowski, M, Filgueiras-Rama, D, Goette, A, Guasch, E, Hack, G, Hatem, S, Haeusler, KG, Healey, JS, Heidbuechel, H, Hijazi, Z, Hofmeister, LH, Hove-Madsen, L, Huebner, T, Kääb, S, Kotecha, D, Malaczynska-Rajpold, K, Merino, JL, Metzner, A, Mont, L, Ng, GA, Oeff, M, Parwani, AS, Puererfellner, H, Ravens, U, Rienstra, M, Sanders, P, Scherr, D, Schnabel, R, Schotten, U, Sohns, C, Steinbeck, G, Steven, D, Toennis, T, Tzeis, S, van Gelder, IC, van Leerdam, RH, Vernooy, K, Wadhwa, M, Wakili, R, Willems, S, Witt, H, Zeemering, S & Kirchhof, P 2024, 'Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference', Europace, vol. 26, no. 4, euae070. https://doi.org/10.1093/europace/euae070
Khan, N, Steeds, R, Kyte, D, Fabritz, L, Collis, P, Chua, WWL, Stubbs, C, Mehta, S, Sun, Y, Nulty, M, Kirkham, K & Cotton, JM 2024, 'Pilot study to evaluate the use of remote patient monitoring to guide the timing of valve intervention in patients with severe asymptomatic aortic stenosis (APRAISE-AS): study protocol for a randomised controlled trial delivered in two tertiary cardiac centres in the UK', BMJ open, vol. 14, no. 6, e086587. https://doi.org/10.1136/bmjopen-2024-086587
Editorial
Lemoine, MD & Fabritz, L 2025, 'Improving antiarrhythmic therapy for patients with atrial fibrillation using common genetic variants', Heart, vol. 111, no. 4, pp. 145-146. https://doi.org/10.1136/heartjnl-2024-325242
Review article
Fabritz, L, Hatem, SN & Sossalla, S 2025, 'Arrhythmia-induced cardiomyopathy: focus on atrial fibrillation', Nature Reviews Cardiology. https://doi.org/10.1038/s41569-025-01195-2
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