Dr Katja Gehmlich

Dr Katja Gehmlich

Institute of Cardiovascular Sciences
Senior Lecturer

Contact details

Address
Institute of Cardiovascular Sciences
College of Medical and Dental Sciences
Univeristy of Birmingham
Edgbaston
Birmingham
B15 2TT

Dr. Katja Gehmlich is Senior Lecturer in the Institute of Cardiovascular Sciences.

She is interested in how genetic variants in genes coding for proteins involved in biomechanical stress signalling cause inherited cardiac conditions (cardiomyopathies). She employs molecular, biophysical, cellular and in vivo models in her research. In particular she is interested in using induced pluripotent stem cell derived cardiomyocytes in her research.

 

Qualifications

  • PhD (Dr. rer. nat.) in Cell Biology 2005

  • Diploma (MSc equivalent) in Chemistry 2001

Biography

Dr. Katja Gehmlich graduated with a Diploma in Chemistry (with Molecular and Cellular Biology) from the University of Potsdam, Germany in 2001. She received a PhD in Cell Biology from the same university in 2005.

Dr Gehmlich came to the UK for her postdoctoral training and work at the University of Manchester (2005-2007), University College London (2007 – 2010) and University of Oxford (2010 – 2013).

She was awarded a British Heart Foundation Intermediate Basic Science Research Fellowship (2013 – 2020). She received the title University Research Lecturer from the University of Oxford in 2016 and became Associate Professor in 2018. She has an active secondary affiliation with Cardiovascular Medicine in the Radcliffe Department of Medicine at the University of Oxford.

She has a long standing interest in the cardiac system with focus on inherited cardiac conditions (cardiomyopathies) and bio-mechanical stress signalling.

Teaching

Dr. Katja Gehmlich has extensive experience in supervision of undergraduate research students.

Postgraduate supervision

Dr. Katja Gehmlich has supervised numerous postgraduate students (2 completed, one active). She accepts PhD students in her group, e.g. with interest in projects using induced pluripotent stem cell derived cardiomyocytes to understand biomechanical stress signalling in the heart.

Research

Dr. Katja Gehmlich has a long standing interest into striated muscle systems.

Her research pursues the following questions:

  • What is the role of certain signalling proteins in the heart?
  • What are the consequences of genetic variants in these proteins? How do they cause inherited cardiac conditions (called cardiomyopathies)?
  • Can these diseases be modelled with the help of in vivo models and/or induced pluripotent stem cell derived cardiomyocytes?


Dr Gehmlich collaborates with other research groups such as:

Other activities

Dr. Katja Gehmlich is peer reviewer for various International journals and funding agencies. She is member of the editorial board of Biophysical Reviews.

Publications

Recent publications

Article

Azad, A, Poloni, G, Sontayananon, N, Jiang, H & Gehmlich, K 2019, 'The giant titin: how to evaluate its role in cardiomyopathies', Journal of Muscle Research and Cell Motility. https://doi.org/10.1007/s10974-019-09518-w

Collier, MP, Alderson, TR, de Villiers, CP, Nicholls, D, Gastall, HY, Allison, TM, Degiacomi, MT, Jiang, H, Mlynek, G, Furst, DO, van der Ven, PFM, Djinovic-Carugo, K, Baldwin, AJ, Watkins, H, Gehmlich, K & Benesch, JLP 2019, 'HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C', Science Advances, vol. 5, no. 5, eaav8421. https://doi.org/10.1126/sciadv.aav8421

Gehmlich, K & Ehler, E 2018, 'Non-sarcomeric causes of heart failure', Biophysical Reviews, vol. 10, no. 4, pp. 943-947. https://doi.org/10.1007/s12551-018-0444-1

Ehsan, M, Kelly, M, Hooper, C, Yavari, A, Beglov, J, Bellahcene, M, Ghataorhe, K, Poloni, G, Goel, A, Kyriakou, T, Fleischanderl, K, Ehler, E, Makeyev, E, Lange, S, Ashrafian, H, Redwood, C, Davies, B, Watkins, H & Gehmlich, K 2018, 'Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion', Journal of Molecular and Cellular Cardiology, vol. 121, pp. 287-296. https://doi.org/10.1016/j.yjmcc.2018.07.248

Rowlands, CT, Owen, T, Lawal, S, Cao, S, Pandey, SS, Yang, H-Y, Song, W, Wilkinson, R, Alvarez-Laviada, A, Gehmlich, K, Marston, SB & MacLeod, KT 2017, 'Age- and strain-related aberrant Ca2+ release is associated with sudden cardiac death in the ACTC E99K mouse model of hypertrophic cardiomyopathy', American Journal of Physiology Heart and Circulatory Physiology, vol. 313, no. 6, pp. H1213-H1226. https://doi.org/10.1152/ajpheart.00244.2017

Yavari, A, Bellahcene, M, Bucchi, A, Sirenko, S, Pinter, K, Herring, N, Jung, JJ, Tarasov, KV, Sharpe, EJ, Wolfien, M, Czibik, G, Steeples, V, Ghaffari, S, Nguyen, C, Stockenhuber, A, St Clair, JR, Rimmbach, C, Okamoto, Y, Yang, D, Wang, M, Ziman, BD, Moen, JM, Riordon, DR, Ramirez, C, Paina, M, Lee, J, Zhang, J, Ahmet, I, Matt, MG, Tarasova, YS, Baban, D, Sahgal, N, Lockstone, H, Puliyadi, R, de Bono, J, Siggs, OM, Gomes, J, Muskett, H, Maguire, ML, Beglov, Y, Kelly, M, Dos Santos, PPN, Bright, NJ, Woods, A, Gehmlich, K, Isackson, H, Douglas, G, Ferguson, DJP, Schneider, JE, Tinker, A, Wolkenhauer, O, Channon, KM, Cornall, RJ, Sternick, EB, Paterson, DJ, Redwood, CS, Carling, D, Proenza, C, David, R, Baruscotti, M, DiFrancesco, D, Lakatta, EG, Watkins, H & Ashrafian, H 2017, 'Mammalian γ2 AMPK regulates intrinsic heart rate', Nature Communications, vol. 8, no. 1, 1258. https://doi.org/10.1038/s41467-017-01342-5

Smart, N, Riegler, J, Turtle, CW, Lygate, CA, McAndrew, DJ, Gehmlich, K, Dubé, KN, Price, AN, Muthurangu, V, Taylor, AM, Lythgoe, MF, Redwood, C & Riley, PR 2017, 'Aberrant developmental titin splicing and dysregulated sarcomere length in Thymosin β4 knockout mice', Journal of Molecular and Cellular Cardiology, vol. 102, pp. 94-107. https://doi.org/10.1016/j.yjmcc.2016.10.010

Hastings, R, de Villiers, CP, Hooper, C, Ormondroyd, L, Pagnamenta, A, Lise, S, Salatino, S, Knight, SJL, Taylor, JC, Thomson, KL, Arnold, L, Chatziefthimiou, SD, Konarev, PV, Wilmanns, M, Ehler, E, Ghisleni, A, Gautel, M, Blair, E, Watkins, H & Gehmlich, K 2016, 'Combination of whole genome sequencing, linkage, and functional studies implicates a missense mutation in titin as a cause of autosomal dominant cardiomyopathy with features of left ventricular noncompaction', Circulation: Cardiovascular Genetics, vol. 9, no. 5, pp. 426-435. https://doi.org/10.1161/CIRCGENETICS.116.001431

Lange, S, Gehmlich, K, Lun, AS, Blondelle, J, Hooper, C, Dalton, ND, Alvarez, EA, Zhang, X, Bang, M-L, Abassi, YA, Dos Remedios, CG, Peterson, KL, Chen, J & Ehler, E 2016, 'MLP and CARP are linked to chronic PKCα signalling in dilated cardiomyopathy', Nature Communications, vol. 7, 12120. https://doi.org/10.1038/ncomms12120

Schlipp, A, Schinner, C, Spindler, V, Vielmuth, F, Gehmlich, K, Syrris, P, Mckenna, WJ, Dendorfer, A, Hartlieb, E & Waschke, J 2014, 'Desmoglein-2 interaction is crucial for cardiomyocyte cohesion and function', Cardiovascular Research, vol. 104, no. 2, pp. 245-57. https://doi.org/10.1093/cvr/cvu206

Rasmussen, TB, Nissen, PH, Palmfeldt, J, Gehmlich, K, Dalager, S, Jensen, UB, Kim, WY, Heickendorff, L, Mølgaard, H, Jensen, HK, Baandrup, UT, Bross, P & Mogensen, J 2014, 'Truncating plakophilin-2 mutations in arrhythmogenic cardiomyopathy are associated with protein haploinsufficiency in both myocardium and epidermis', Circulation: Cardiovascular Genetics, vol. 7, no. 3, pp. 230-40. https://doi.org/10.1161/CIRCGENETICS.113.000338

Review article

Vimalanathan, AK, Ehler, E & Gehmlich, K 2018, 'Genetics of and pathogenic mechanisms in arrhythmogenic right ventricular cardiomyopathy', Biophysical Reviews, vol. 10, no. 4, pp. 973-982. https://doi.org/10.1007/s12551-018-0437-0

Ehsan, M, Jiang, H, L Thomson, K & Gehmlich, K 2017, 'When signalling goes wrong: pathogenic variants in structural and signalling proteins causing cardiomyopathies', Journal of Muscle Research and Cell Motility, vol. 38, no. 3-4, pp. 303-316. https://doi.org/10.1007/s10974-017-9487-3

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