Dr Melanie Madhani

Dr Melanie Madhani

Institute of Cardiovascular Sciences
Senior Lecturer in Cardiovascular Medicine

Contact details

Address
Institute of Cardiovascular Sciences
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Melanie Madhani is a Senior Lecturer in Cardiovascular Medicine within the Institute of Cardiovascular Sciences. 

Dr Madhani works on understanding the mechanisms of heart disease, and leads a translational research group in myocardial infarction and heart failure. Her research group is assessing novel pharmacological strategies to protect the heart against from ischaemia reperfusion injury and heart failure, with scientists and clinical research fellows working together from “bench to bedside, and back again”.  

Biography

Dr Melanie Madhani graduated from the University of Wales College Of Medicine in 1998 and obtained a PhD in Cardiovascular Sciences from the Ivy League School, Dartmouth College, New Hampshire, USA and University of Wales in 2002. She then joined University College London (UCL) as a British Heart Foundation research fellow, to work under Dr Adrian Hobbs. Here, she investigated the role of nitric oxide (NO) in cardiovascular diseases. Dr Madhani was awarded a UCL Bogue Fellowship to work with Nobel Laureate Dr Louis Ignarro, University of California, LA, USA. In 2005, she joined Dr Philip Eaton's research group at The Rayne Institute, King's College London, where she broadened her experience in cardiac physiology in order to complement her vascular knowledge and skills into NO regulation during myocardial ischaemia reperfusion injury. In 2009, the University of Birmingham appointed Dr Madhani and is a Senior Lecturer in Cardiovascular Medicine. Here, she continues with her research  in this field and collaborates with Prof Frenneaux (University of East Anglia), Prof Feelisch (University of Southampton), Prof Horowitz (Queen Elizabeth Hospital, University of Adelaide, Australia), and Prof Underwood (Prince of Wales Hospital, Chinese University of Hong Kong). Dr Madhani is also the Treasurer for the British Society for Cardiovascular Research and holds an Adjunct Honorary Assistant Professor position at the Department of Medicine and Therapeutics, Chinese University of Hong Kong. 

Teaching

  • Deputy Module Co-ordinator for 3rd Year BMed Sc module: Cardiovascular
  • Lectures for Cardiovascular modules to 1st and 3rd Year BMedSc, MPharm, MBChB, Graduate Entry Course in Medicine and MRes programmes
  • Personal Mentor for MBChB
  • Postgraduate supervision for basic scientists and clinicians 

Postgraduate supervision

I currently have openings for self-funded MRes and PhD students in the area of:

(1)     Cardiac metabolism in heart failure

(2)     The role of nitrite against myocardial reperfusion injury and heart failure

 Please email: m.madhani@bham.ac.uk 

Research

Dr Madhani leads a research group to characterise the functional deterioration within the heart following myocardial infarction and heart failure. Novel pharmacological methods of improving outcomes are also investigated. Her research group is investigating: 

  • Novel protective strategies against ischaemia reperfusion in patients undergoing coronary artery bypass grafting surgery
  • Assessing the protective role of nitrite against myocardial reperfusion injury and heart failure
  • Perhexiline and cardiac metabolism in heart failure

Other activities

  • NC3Rs Studentship Grant Assessment Panel (2020-2022)
  • Treasurer for the British Society for Cardiovascular Research (2014-2019)
  • Adjunct Assistant Professor at the Department of Medicine and Therapeutics, Chinese University of Hong Kong
  • International Strategy Development for the Institute of Cardiovascular Sciences (2016)
  • Review Editor of Frontiers in Clinical & Translational Physiology (2009- present)
  • Associate Editor for International Journal for Pharmacology & Therapeutics (2006-2013)
  • Bulletin Editor for the British Society for Cardiovascular Research (2009-2013)

Publications

Recent publications

Article

Feelisch, M, Akaike, T, Griffiths, K, Ida, T, Prysyahna, O, Goodwin, JJ, Gollop, ND, Fernandez, BO, Minnion, M, Cortese-Krott, MM, Borgognone, A, Hayes, RM, Eaton, P, Frenneaux, MP & Madhani, M 2020, 'Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides and oxidation of protein kinase G 1α redox signaling', Cardiovascular Research, vol. 116, no. 1, cvz202, pp. 51-62. https://doi.org/10.1093/cvr/cvz202

Sutton, TR, Minnion, M, Barbarino, F, Koster, G, fernandez, BO, Cumpstey, AF, Wischmann, P, Madhani, M, Frenneaux, MP, Postle, AD, Cortese-Krott, MM & Feelisch, M 2018, 'A robust and versatile mass spectrometry platform for comprehensive assessment of the thiol redox metabolome', Redox Biology, vol. 16, pp. 359-380. https://doi.org/10.1016/j.redox.2018.02.012

Borgognone, A, Shantsila, E, Worrall, S, Prompunt, E, Loka, T, Loudon, BL, Chimen, M, Rainger, GE, Lord, JM, Turner, A, Nightingale, P, Feelisch, M, Kirchhof, P, Lip, G, Watson, SP, Frenneaux, MP & Madhani, M 2018, 'Nitrite circumvents platelet resistance to nitric oxide in patients with heart failure preserved ejection fraction and chronic atrial fibrillation', Cardiovascular Research, vol. 114, pp. 1313–1323. https://doi.org/10.1093/cvr/cvy087

Madhani, M 2017, 'Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy', Journal of Medicinal Chemistry, vol. 60, no. 7, pp. 2780-2789. https://doi.org/10.1021/acs.jmedchem.6b01592

Noordali, H, Loudon, B, Frenneaux, M & Madhani, M 2017, 'Cardiac metabolism - a promising therapeutic target for heart failure', Pharmacology & Therapeutics. https://doi.org/10.1016/j.pharmthera.2017.08.001

Madhani, M 2017, 'Inorganic Nitrate in Angina Study: A Randomized Double-Blind Placebo-Controlled Trial', Journal of the American Heart Association, vol. 6, no. 9, e006478. https://doi.org/10.1161/JAHA.117.006478

Madhani, M, Noordali, H, Frenneaux, M, Loudon, B & Gollop, ND 2016, 'Present and future pharmacotherapeutic agents in heart failure: An evolving paradigm', British Journal of Pharmacology, vol. 173 , no. 12, pp. 1911-1924. https://doi.org/10.1111/bph.13480

Arif, S, Borgognone, A, Lin, EL, O'sullivan, AG, Sharma, V, Drury, NE, Menon, A, Nightingale, P, Mascaro, J, Bonser, RS, Horowitz, JD, Feelisch, M, Frenneaux, MP & Madhani, M 2015, 'Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans', British Journal of Pharmacology, vol. 172, no. 13, pp. 3341-3352. https://doi.org/10.1111/bph.13122

Ormerod, JOM, Arif, S, Mukadam, M, Evans, JDW, Beadle, R, Fernandez, BO, Bonser, RS, Feelisch, M, Madhani, M & Frenneaux, MP 2015, 'Short-term intravenous sodium nitrite infusion improves cardiac and pulmonary hemodynamics in heart failure patients', Circulation. Heart failure, vol. 8, no. 3, pp. 565-571. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001716

Bailey, JC, Feelisch, M, Horowitz, JD, Frenneaux, MP & Madhani, M 2014, 'Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation', Pharmacology & Therapeutics, vol. 144, no. 3, pp. 303-320. https://doi.org/10.1016/j.pharmthera.2014.06.009

Dautov, RF, Stafford, I, Liu, S, Cullen, H, Madhani, M, Chirkov, YY & Horowitz, JD 2014, 'Hypoxic potentiation of nitrite effects in human vessels and platelets', Nitric Oxide, vol. 40, pp. 36-44. https://doi.org/10.1016/j.niox.2014.05.005

Siddiqi, N, Neil, C, Bruce, M, MacLennan, G, Cotton, S, Papadopoulou, S, Feelisch, M, Bunce, N, Lim, PO, Hildick-Smith, D, Horowitz, J, Madhani, M, Boon, N, Dawson, D, Kaski, JC, Frenneaux, M & NIAMI investigators 2014, 'Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)', European Heart Journal, vol. 35, no. 19, pp. 1255-62. https://doi.org/10.1093/eurheartj/ehu096

Borgognone, A, Navarro-Nunez, L, Correia, JN, Pollitt, AY, Thomas, SG, Eble, JA, Pulcinelli, FM, Madhani, M & Watson, SP 2014, 'CLEC-2-dependent activation of mouse platelets is weakly inhibited by cAMP but not by cGMP', Journal of Thrombosis and Haemostasis, vol. 12, no. 4, pp. 550-559. https://doi.org/10.1111/jth.12514

Borgognone, A, Lowe, KL, Watson, SP & Madhani, M 2014, 'Natriuretic peptides induce weak VASP phosphorylation at Serine 239 in platelets', Platelets, vol. 25, no. 1, pp. 1-7. https://doi.org/10.3109/09537104.2013.773969

Maher, AR, Arif, S, Madhani, M, Abozguia, K, Ahmed, I, Fernandez, BO, Feelisch, M, O'Sullivan, AG, Christopoulos, A, Sverdlov, AL, Ngo, D, Dautov, R, James, PE, Horowitz, JD & Frenneaux, MP 2013, 'Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite', British Journal of Pharmacology. https://doi.org/10.1111/bph.12152

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