Dr Melanie Madhani

Dr Melanie Madhani

Institute of Cardiovascular Sciences
Senior Lecturer in Cardiovascular Medicine

Contact details

Address
Institute of Cardiovascular Sciences
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Melanie Madhani is a Senior Lecturer in Cardiovascular Medicine within the Institute of Cardiovascular Sciences. 

Dr Madhani works on understanding the mechanisms of heart disease, and leads a translational research group in myocardial infarction and heart failure. Her research group is assessing novel pharmacological strategies to protect the heart against from ischaemia reperfusion injury and heart failure, with scientists and clinical research fellows working together from “bench to bedside, and back again”.  

Biography

Dr Melanie Madhani graduated from the University of Wales College Of Medicine in 1998 and obtained a PhD in Cardiovascular Sciences from the Ivy League School, Dartmouth College, New Hampshire, USA and University of Wales in 2002. She then joined University College London (UCL) as a British Heart Foundation research fellow, to work under Dr Adrian Hobbs. Here, she investigated the role of nitric oxide (NO) in cardiovascular diseases. Dr Madhani was awarded a UCL Bogue Fellowship to work with Nobel Laureate Dr Louis Ignarro, University of California, LA, USA. In 2005, she joined Dr Philip Eaton's research group at The Rayne Institute, King's College London, where she broadened her experience in cardiac physiology in order to complement her vascular knowledge and skills into NO regulation during myocardial ischaemia reperfusion injury. In 2009, the University of Birmingham appointed Dr Madhani and is a Senior Lecturer in Cardiovascular Medicine. Here, she continues with her research  in this field and collaborates with Prof Frenneaux (University of East Anglia), Prof Feelisch (University of Southampton), Prof Horowitz (Queen Elizabeth Hospital, University of Adelaide, Australia), and Prof Underwood (Prince of Wales Hospital, Chinese University of Hong Kong). Dr Madhani is also the Treasurer for the British Society for Cardiovascular Research and holds an Adjunct Honorary Assistant Professor position at the Department of Medicine and Therapeutics, Chinese University of Hong Kong. 

Teaching

  • Deputy Module Co-ordinator for 3rd Year BMed Sc module: Cardiovascular
  • Lectures for Cardiovascular modules to 1st and 3rd Year BMed Sc, MPharm,  MBChB, Graduate Entry Course in Medicine and MRes  programmes
  • Personal Mentor for MBChB
  • Postgraduate supervision for basic scientists and clinicians 

Postgraduate supervision

I currently have openings for self-funded MRes and PhD students in the area of:

(1)     Cardiac metabolism in heart failure

(2)     The role of nitrite against myocardial reperfusion injury and heart failure

 Please email: m.madhani@bham.ac.uk

Research

Dr Madhani leads a research group to characterise the functional deterioration within the heart following myocardial infarction and heart failure. Novel pharmacological methods of improving outcomes are also investigated. Her research group is investigating: 

  • Novel protective strategies against ischaemia reperfusion in patients undergoing coronary artery bypass grafting surgery
  • Assessing the protective role of nitrite against myocardial reperfusion injury and heart failure
  • Perhexiline and cardiac metabolism in heart failure

Other activities

  • Treasurer for the British Society for Cardiovascular Research (2014-2017)
  • Adjunct Assistant Professor at the Department of Medicine and Therapeutics, Chinese University of Hong Kong
  • International Strategy Development for the Institute of Cardiovascular Sciences (2016)
  • Review Editor of Frontiers in Clinical & Translational Physiology (2009- present)
  • Associate Editor for International Journal for Pharmacology & Therapeutics (2006-2013)
  • Bulletin Editor for the British Society for Cardiovascular Research (2009-2013)

Publications

Please view a full list of Dr Madhani’s publications

Feelisch M, Akaike T, Griffiths K, Ida T, Prysyahna O, Goodwin JJ, Gollop ND, Fernandez BO, Minnion M, Cortese-Krott MM, Borgognone A, Hayes RM, Eaton P, Frenneaux MP, Madhani M. Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides and oxidation of protein kinase G 1α redox signaling. Cardiovasc Res. 2019 Jul 31.

Borgognone A, Shantsila E, Worrall SM, Prompunt E, Loka T, Loudon BL, Chimen M, Rainger GE, Lord JM, Turner A, Nightingale P, Feelisch M, Kirchhof P, Lip GYH, Watson SP, Frenneaux MP, Madhani M. Nitrite circumvents platelet resistance to nitric oxide in patients with heart failure preserved ejection fraction and chronic atrial fibrillation. Cardiovasc Res. 2018 Apr 12.

Sutton TR, Minnion M, Barbarino F, Koster G, Fernandez BO, Cumpstey AF, Wischmann P, Madhani M, Frenneaux MP, Postle AD, Cortese-Krott MM, Feelisch M. A robust and versatile mass spectrometry platform for comprehensive assessment of the thiol redox metabolome. Redox Biol. 2018 Jun;16:359-380. doi: 10.1016/j.redox.2018.02.012. Epub 2018 Feb 19.

Schwarz K, Singh S, Parasuraman SK, Rudd A, Shepstone L, Feelisch M, Minnion M, Ahmad S, Madhani M, Horowitz J, Dawson DK, Frenneaux MP. Inorganic Nitrate in Angina Study: A Randomized Double-Blind Placebo-Controlled Trial. J Am Heart Assoc. 2017 Sep 8;6(9). pii: e006478. doi: 10.1161/JAHA.117.006478.

Noordali H, Loudon BL, Frenneaux MP, Madhani M. Cardiac metabolism - A promising therapeutic target for heart failure. Pharmacol Ther. 2018 Feb;182:95-114. doi: 10.1016/j.pharmthera.2017.08.001. Epub 2017 Aug 15.

Loudon BL, Noordali H, Gollop ND, Frenneaux MP, Madhani M. Present and future pharmacotherapeutic agents in heart failure: an evolving paradigm. Br J Pharmacol. 2016 Jun;173(12):1911-24. doi: 10.1111/bph.13480. Epub 2016 May 6.

Ormerod JO, Arif S, Mukadam M, Evans JD, Beadle R, Fernandez BO, Bonser RS, Feelisch M, Madhani M, Frenneaux MP. Short-term intravenous sodium nitrite infusion improves cardiac and pulmonary hemodynamics in heart failure patients. Circ Heart Fail. 2015 May;8(3):565-71. doi: 10.1161/CIRCHEARTFAILURE.114.001716. Epub 2015 Apr 2.

Dautov RF, Stafford I, Liu S, Cullen H, Madhani M, Chirkov YY and Horowitz JD. Hypoxic potentiation of nitrite effects in human vessels and platelets. Nitric Oxide. 2014 August; (40) 36-44.

Siddiqi N, Bruce M, Neil CJ, Jagpal B, Maclennon G , Cotton SC, Papadopoulo SA, Bunce N, Schwarz LPK, Singh S, Hildick-Smith D, Horowitz JD, Madhani M, Boon N, Kaski JC, Dawson D and Frenneaux MP. Intravenous sodium nitrite in acute ST elevation myocardial infarction: a randomised controlled trial (NIAMI). European Heart Journal 2014 May 14; 35(19):1255-62.

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