Dr Myriam Chimen MSc, PhD

Myriam Chimen

Institute of Cardiovascular Sciences
Royal Society Dorothy Hodgkin Research Fellow

Contact details

Address
Institute of Cardiovascular Sciences
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Myriam Chimen is Royal Society Dorothy Hodgkin Research Fellow since October 2017. Her main interest is to understand how immune regulatory pathways controlling leukocyte trafficking are impaired with ageing and chronic inflammatory diseases. 

Qualifications

  • Royal Society Dorothy Hodgkin fellowship (2017)
  • PhD, University of Birmingham (2012)
  • Masters Biochemistry University of Toulouse, France (2008)

Biography

Myriam completed her undergraduate degree in Biochemistry at the University of Toulouse in France. She then completed her Masters in Biochemistry and Molecular Biology at the University of Toulouse where she developed a strong interest in immunology. She decided to move to Birmingham in the laboratory of Dr Parth Narendran and Professor Ed Rainger where she investigated the immune-modulatory effects of adipokines in type 1 diabetes. Myriam completed her PhD in 2012 where she discovered a novel peptide inhibitor of trans-endothelial migration (PEPITEM) and characterised this novel pathway in health and patients with type 1 diabetes.

Myriam has continued her post-doctoral training in Birmingham on the characterisation of the receptor for PEPITEM. She then embarked on her second post-doctoral position in the laboratory of Professor Ed Rainger where she was investigating the role of platelet-monocyte interactions in the pathogenesis of atherosclerosis.  Myriam has now started working on her five-year fellowship to investigate how glucocorticoids modulate the PEPITEM pathway in ageing

Dr Myriam Chimen along with Professor Ed Rainger and Dr Asif Iqbal talk about their work to understand how inflammation affects the Cardiovascular System with the goal to transfer their findings to benefit patients.

Teaching

  • BMedSc
  • MSc

Postgraduate supervision

Myriam is interested in supervising doctoral research students in the following areas:

  • Effect of age on leukocyte migration
  • Glucocorticoids and their involvement in controlling T-cell trafficking

If you are interested in studying any of these subject areas please contact Myriam on the contact details above. For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

Myriam’s research is focused on understanding how immune regulatory pathways are changed with ageing and age-associated chronic inflammatory conditions. In particular, Myriam wishes to investigate how the control of leukocyte trafficking is affected by the chronic, low grade, chronic inflammation (Inflammageing) associated with ageing.

  • Effect of ageing on the PEPITEM pathway
  • Role of glucocorticoids in the regulation of the PEPITEM pathway
  • Effect of ageing on B-cell trafficking

Other activities

Committee membership:

  • UK Cell Adhesion Society (UKCAS
  • BSI Leukocyte Migration Affinity Group
  • PERCAT University of Birmingham

Conference organisation:

  • Co-organiser of the 2nd ICVS away day conference  (2017)
  • Co-organiser of the 3rd BSI Leukocyte Migration Affinity Meeting - University of Leeds (2017)
  • Co-organiser of the 3rd PERCAT gala- University of Birmingham (2016)
  • Co-organiser of the 27th UK Adhesion Society Meeting in Birmingham (2015)
  • Co-organiser of the 26th UK Adhesion Society Meeting in Birmingham (2013)

Publications

Original research articles:

Reyat J, Chimen M, Noy P, Rainger G Ed and Tomlinson M. ADAM10-interacting tetraspanins Tspan5 and Tspan17 regulate VE-cadherin expression and promote T lymphocyte transmigration. Journal of Immunology.  Jul 15;199(2):666-676 (2017)

Chimen M, Yates CM, McGettrick HM, Harrison MJ, Apta B, Dib LH, Imhof BA, Harrison P, Nash GB and Rainger G Ed. Monocyte subsets co-regulate inflammatory responses by integrated signalling through TNF-alpha and IL-6 at the endothelial cell interface. Journal of Immunology 198(7): 2834-2843 (2017).

Chimen M, McGettrick HM, Apta B, Kuravi JS, Yates CM, Kennedy A, Odedra A, Alassiri M, Harrison MJ, Martin A, Barone F,  Nayar S, Hitchcock JR, Cunningham AF, Raza K, Filer A, Copland DA, Dick AD, Robinson J, Kalia N, Walker LSK, Buckley CD, Nash GB, Narendran P and Rainger GE. Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease. Nature Medicine 21, 467–475 (2015).

Robertson AL, Holmes GR, Bojarczuk AN, Burgon J, Loynes CA, Chimen M, Sawtell AK, Hamza B, Willson J, Walmsley SR, Anderson SR, Coles MC, Farrow SN, Solari R, Jones S, Prince LR, Irimia D, Rainger GE, Kadirkamanathan V, Whyte MK and Renshaw SA. A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism. Sci Transl Med.26;6(225) (2014).

Kennedy A, Nirantharakumar K, Chimen M, Pang TT, Hemming K, Andrews RC and Narendran P (2013) Does exercise improve glycaemic control in type 1 diabetes? A systematic review and meta-analysis. PLoS One 8(3)

Pang TT, Chimen M, Goble E, Dixon N, Benbow A, Eldershaw SE, Thompson D, Gough SC and Narendran P (2013) Inhibition of islet immunoreactivity by adiponectin is attenuated in human type 1 diabetes. J Clin Endocrinol Metab 98(3):E418-28

Reviews:

Rainger GE, Chimen M, Harrison MJ, Lordkipanidze M, Yates CM, Harrison P, Watson SP and Nash GB.The role of platelet in the recruitment of leukocyte during vascular disease. Platelets 26(6):507-20 (2015).

Narendran P, Solomon TP, Kennedy A, Chimen M and Andrews R. The time has come to test the beta cell preserving effects of exercise in patients with new onset type 1 diabetes.  Diabetologia58 (1) 10-8 (2015).

Chimen M, Kennedy A, Nirantharakumar K, Pang TT, Andrews R and Narendran P (2012) What are the health benefits of physical activity in type 1 diabetes mellitus? A literature review. Diabetologia 55(3):542-51

Book Chapters:

Chimen M, Apta B and McGettrick HM. Introduction: T-cell trafficking during inflammation. T-cell trafficking 2nd Ed: Methods in Molecular Biology, 1591:73-84 (2017).

Apta B, Chimen M and McGettrick HM. Endocrine regulation of T-cell trafficking in vitro. T-cell trafficking 2nd Ed: Methods in Molecular Biology, 1591: 101-119 (2017)

View all publications in research portal