Dr Ingrid Dumitriu MD, PhD, FESC, FHEA

Dr Ingrid Dumitriu

Institute of Cardiovascular Sciences
Reader in Cardiovascular Immunology
PGR Clinical Lead
Theme Lead - Vascular Biology and Inflammation

Contact details

Address
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Ingrid Dumitriu is a Reader in Cardiovascular Immunology in the Institute of Cardiovascular Sciences at the University of Birmingham.

Dr Dumitriu’s research interrogates the cellular and molecular mechanisms involved in sustaining inflammation in cardiovascular diseases. Specifically, her group focuses on gaining an in-depth understanding of the role of inflammation and immune cells in atherosclerosis and atrial fibrillation, with the aim to develop specific immunomodulation therapeutic strategies to improve management and outcomes of patients with cardiovascular disorders.

Dr Dumitriu is a Fellow of the European Society of Cardiology (ESC) and a nucleus member of the ESC Working Group on Atherosclerosis and Vascular Biology.

Qualifications

  • FESC (Fellow of the European Society of Cardiology)
  • FHEA (Fellow of the Higher Education Academy)
  • PhD Immunology (Cellular and Molecular Biology Programme), DIBIT Scientific Institute, San Raffaele, Milan, Italy
  • MD (Doctor in Medicine), University of Medicine and Pharmacy Grigore T. Popa, Iasi, Romania

Biography

Dr Dumitriu joined the Institute of Cardiovascular Sciences at the University of Birmingham in 2020. Prior to this, she was a Reader at St. George’s, University of London, where she lead the Cardiovascular Immunology research group in the Cardiology Clinical Academic group, Molecular and Clinical Sciences Research Institute. She secured competitive research funding and set up a patient-oriented research programme on the immune cells that regulate the complex inflammatory networks underlying atherosclerosis and atrial fibrillation with a view to applying this knowledge for targeted immunomodulation in cardiovascular disorders. Other research areas included checkpoint inhibitors/costimulatory molecules and angiogenesis in cancer. This research resulted in a number of publications (Cardiovascular Research 2019, Frontiers in Immunology 2019, European Heart Journal - Cardiovascular Pharmacotherapy 2016, Circulation 2015, British Journal of Cancer 2015, Circulation Research 2012) and presentations at international scientific conferences and public engagement events.

During her postdoctoral work at Imperial College London and at the MRC Centre for Inflammation Research, University of Edinburgh she worked on regulatory T cells (Treg) in animal models of autoimmune disorders and on Treg induction in lung cancer.

She was awarded her PhD in Immunology at the San Raffaele DIBIT Scientific Institute, Milan, Italy. Her PhD thesis on HMGB1 release from dendritic cells and its role in T cell activation led to seminal publications and was awarded the PBI International Prize by the Italian Society of Immunology.

Teaching

Dr Dumitriu is a Fellow of the Higher Education Academy (HEA). She has extensive teaching experience at undergraduate and postgraduate level.

Current teaching:

Postgraduate supervision

Dr Dumitriu has supervised several postgraduate students: PhD (one active, 1 completed), MD(Res) (1 completed), MRes (3 completed).

Current students under supervision

  • Miss Arthika Surendran (MSc by Research in Cardiovascular Sciences); (main supervisor)
  • Dr Kyaw Saw Win Metchley Park Medical Society and University of Birmingham Starter Fellowship (co-supervisor)
  • Mr Long Wong (BSc in Biomedical Sciences); (main supervisor)

Research

Dr Dumitriu has a long standing research interest in inflammation and immunomodulation in cardiovascular diseases and chronic inflammatory disorders.

Cardiovascular disease is the leading cause of death worldwide and atherosclerosis is a major cause of cardiovascular disease. Innate and adaptive immune cells (such as T cells, regulatory T cells) infiltrate atherosclerotic plaques and influence plaque development and progression. Treatments that specifically target immune cells in atherosclerosis are not currently available. Dr Dumitriu’s research investigates the mechanisms underlying inflammation in atherosclerosis and other cardiovascular and chronic inflammatory diseases and seeks to identify new therapeutic targets. This research has translational applications such as improving the risk stratification, selection into clinical trials, management and outcomes of patients with cardiovascular and inflammatory disorders.

Dr Dumitriu’s research employs several techniques: multi-colour flow-cytometry, cell-sorting, analysis of effector and regulatory T-cell function, transcriptome profiling, immunohistochemistry, confocal microscopy, etc.

Other activities

Dr Dumitriu is a nucleus member of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology. She is also a member of the British Atherosclerosis Society, European Atherosclerosis Society, British Society for Immunology and ESC Working Group on Peripheral Circulation.

Dr Dumitriu reviews grants and fellowships for several national and international funding bodies (British Heart Foundation, Wellcome Trust, MRC, BBSRC, European Commission ERC, ANR France, Austrian Science Fund, Academy of Finland, Health Research Board Ireland, KAW Foundation Sweden). She is a Review Editor on the Editorial Board of Frontiers in Inflammation and a peer reviewer for more than 20 international journals.

Publications

Selected publications

Marianna SarchiotoFranklyn HoweIngrid E. DumitriuFrancesca MorganteJeremy SternMark J. EdwardsDavide Martino Analyses of peripheral blood dendritic cells and magnetic resonance spectroscopy support dysfunctional neuro-immune crosstalk in Tourette syndrome European Journal of Neurology; 26 March 2021; https://doi.org/10.1111/ene.14837 (online ahead of print)

Bullenkamp J, Mengoni V, Kaur S, Chhetri I, Dimou P, Astroulakis ZMJ, Kaski JC, Dumitriu IE. Interleukin-7 and interleukin-15 drive CD4+CD28null T lymphocyte expansion and function in patients with acute coronary syndrome. Cardiovasc Res. 2020 Jul 9:cvaa202. doi: 10.1093/cvr/cvaa202 (online ahead of print)

Ketelhuth D.F.J., Lutgens E., Bäck M., Binder C.J., Van den Bossche J., Daniel C., Dumitriu I.E., Hoefer I., Libby P., O’Neill L., Weber C., and Evans P.C. (2019 ) Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology. Cardiovascular Research 115(9): 1385-1392, (Editor’s Choice)

Baruah P., Bullenkamp J., Wilson P.O.G., Lee M., Kaski J.C. and Dumitriu I.E. (2019 ) TLR9 mediated tumour-stroma interactions in human papilloma virus (HPV)-positive head and neck squamous cell carcinoma up-regulate PD-L1 and PD-L2. Frontiers in Immunology 10: 1644, July 2019

Bullenkamp J., Dinkla S., Kaski J.C. and Dumitriu I.E. (2016) Targeting T cells to treat atherosclerosis: odyssey from bench to bedside. European Heart Journal – Cardiovascular Pharmacotherapy 2(3): 194-199, (Editor’s choice)

Buckley R.J., Whitley G.S., Dumitriu I.E. and Cartwright J.E. (2016) Macrophage polarisation affects their regulation of trophoblast behavior. Placenta 47: 73-80

Dinkla S., van Cranenbroek B., van der Heijden W.A., He X., Wallbrecher R., Dumitriu I.E, van der Ven A.J., Bosman G.J., Koenen H.J. and Joosten I. (2016) Platelet-derived microparticles inhibit IL-17 production by regulatory T cells through P-selectin. Blood 127(16): 1976-1986

Kovalcsik E., Antunes R.F., Baruah P., Kaski J.C. and Dumitriu I.E. (2015) Proteasome-mediated reduction in pro-apoptotic molecule Bim renders CD4+CD28null T cells resistant to apoptosis in acute coronary syndrome. Circulation 131(8): 709-720

Dumitriu I.E. (2015) The life (and death) of CD4+CD28null T cells in inflammatory diseases. Immunology 146(2): 185-193

Ford C.A., Petrova S., Pound J.D., Willems J., Melville L., Paterson M., Farnworth S.L., Gallimore A.M., Cuff S., Wheadon H., Dobbin E., Ogden C.A., Dumitriu I.E., Dunbar D.R., Murray P.G., Rucker D., Allen J.E., Hume D.A., van Rooijen N., Goodlad J., Freeman T. and Gregory C.D. (2015) Oncogenic properties of apoptotic tumor cells in aggressive B-cell lymphoma. Current Biology 25(5): 577-588

Baruah P., Lee M., Wilson P., Odutoye T., Williamson P., Hyde N., Kaski J.C. and Dumitriu I.E. (2015) Impact of p16 status on pro- and anti-angiogenesis factors in head and neck cancers. British Journal of Cancer; 113(4): 653-659

Dumitriu I.E., Baruah P., Finlayson C.J., Loftus I.M., Antunes R.F., Lim P., Bunce N. and Kaski J.C. (2012) High levels of costimulatory receptors OX40 and 4-1BB characterise CD4+CD28null T cells in patients with acute coronary syndrome. Circulation Research 110(6): 857-869 (highlighted in Editorial, Olofsson P.S., Circulation Research, 110(6): 800-801, 2012)

 

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